ID   A0A094ZSX0_SCHHA        Unreviewed;       434 AA.
AC   A0A094ZSX0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5 {ECO:0000256|ARBA:ARBA00016279};
GN   ORFNames=MS3_05596 {ECO:0000313|EMBL:KGB37267.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB37267.1};
RN   [1] {ECO:0000313|EMBL:KGB37267.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA   Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA   Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA   Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000256|ARBA:ARBA00005339}.
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DR   EMBL; KL250862; KGB37267.1; -; Genomic_DNA.
DR   RefSeq; XP_012797029.1; XM_012941575.1.
DR   AlphaFoldDB; A0A094ZSX0; -.
DR   STRING; 6185.A0A094ZSX0; -.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd00757; ThiF_MoeB_HesA_family; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   PANTHER; PTHR10953:SF9; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          57..305
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
FT   COILED          6..33
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   434 AA;  48660 MW;  69EEBA8D0AD68E1D CRC64;
     MPSNNKSSLR QTNRNLRAEI DVLKAQIVQM KNDLSQSHTI RPKIDQMSNE VVDSNPYSRL
     MALQRMGVVT NYALIREKTV VIVGIGGVGS VTAEMLVRCG IGRLVLFDYD KVELANMNRL
     FFQPHQSGLS KVAAAASTLS FINPDVQIEA HNYNITLVEN FDHFLNRLEH GGLKDDNPVD
     LVLSCVDNFE ARMTINKAAI FLVWYESGVS EDAVSCHIQL MYPGRTPCFE CLPPLIVASG
     LDEKTLKREG VCAASLPTTM ALVSSLLVQN TLKYLLKFGE VSSYLGYGAA KDSFYRVELK
     ANPDCADSWC NLRQIQWRNH LQQLNLPIDS PWDIEERLEA QQIKNEKLKE ALSKSKHEEN
     DFGIELESES SSFTESTCNI KHDLSNSNSE IIGVKTLYTV DNKKFDSNSQ ETSDSFISQT
     NDSLESLMAK MKNL
//