ID A0A094ZX06_SCHHA Unreviewed; 581 AA.
AC A0A094ZX06;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=O-acyltransferase {ECO:0000256|PIRNR:PIRNR000439};
GN ORFNames=MS3_0013870 {ECO:0000313|EMBL:KAF1321650.1}, MS3_07855
GN {ECO:0000313|EMBL:KGB39425.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB39425.1};
RN [1] {ECO:0000313|EMBL:KGB39425.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1321650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|PIRNR:PIRNR000439}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC Sterol o-acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00009010,
CC ECO:0000256|PIRNR:PIRNR000439}.
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DR EMBL; AMPZ02000426; KAF1321650.1; -; Genomic_DNA.
DR EMBL; KL251201; KGB39425.1; -; Genomic_DNA.
DR RefSeq; XP_012799184.1; XM_012943730.1.
DR AlphaFoldDB; A0A094ZX06; -.
DR STRING; 6185.A0A094ZX06; -.
DR EnsemblMetazoa; XM_012943730.1; XP_012799184.1; MS3_0013870.
DR GeneID; 24595135; -.
DR KEGG; shx:MS3_00002971; -.
DR CTD; 6646; -.
DR OrthoDB; 9612at2759; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR InterPro; IPR004299; MBOAT_fam.
DR InterPro; IPR014371; Oat_ACAT_DAG_ARE.
DR PANTHER; PTHR10408:SF8; O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR10408; STEROL O-ACYLTRANSFERASE; 1.
DR Pfam; PF03062; MBOAT; 1.
DR PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR000439,
KW ECO:0000313|EMBL:KGB39425.1};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|PIRNR:PIRNR000439};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000439};
KW Transferase {ECO:0000256|PIRNR:PIRNR000439, ECO:0000313|EMBL:KGB39425.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 148..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 489
FT /evidence="ECO:0000256|PIRSR:PIRSR000439-1"
SQ SEQUENCE 581 AA; 68508 MW; 2FF288260ECA44DC CRC64;
MQESLVDEMN IRRRHDEKNM KTASTQSLNN LNLQLKEFKI TEQTNSNSPD NDKHKFVHDV
VWCDLAEQFR LNLITQLDEH LKVSLNDLVS TAISRDSYLQ NTQALNDWMT DKHKTECKSL
TSHSLPTKHY RTRDSVLTTL FQISHIRTVY NIFVAVTIIF SANTVIQDFI DPKINLYAYD
MDILRFTFGN LDDVFRIWLS MKMSTIFIPF WGVLLWMAYR PKVGKKICPT DWIFFIAYII
YQVVFFMTSF RFTIICDLPP ASTAIVTGEQ VRLVMKSHAF VRYAIGRIFE EGQDESTPPS
PTTTVTNQSN SCVIEMEEFP NFSRYLYFLL APTLVYREKY PRTRSIRWYF VFSNFLQVIV
CFIFSYYIFM RFCFLPFSQL GKLKKFSFKK YILTSTACTL PGGLLMLIAF YSFLHSWLNA
FAEMLRFGDR LFYKDWWNAT TFSVWYRTWN VIVHDWLYTY IYRDIQFLIG KHSRTLAATA
VFWLSAGVHE YILMMSLRYC LPVLFLFFSV GGYVLFFVQG SGRGWNVVIW ILLFIGWGQM
ICLYSMEWYA RKNCPPVMDG YLNFFMPHII LCPSTNHTGH V
//