ID A0A094ZXI2_SCHHA Unreviewed; 1168 AA.
AC A0A094ZXI2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Putative solute carrier family 12, electroneutral k-cl cotransporter {ECO:0000313|EMBL:KAF1324913.1};
DE SubName: Full=Solute carrier family 12 member 5 {ECO:0000313|EMBL:KGB37884.1};
GN ORFNames=MS3_00004204 {ECO:0000313|EMBL:KAH9592186.1}, MS3_0017240
GN {ECO:0000313|EMBL:KAF1324913.1}, MS3_06245
GN {ECO:0000313|EMBL:KGB37884.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB37884.1};
RN [1] {ECO:0000313|EMBL:KGB37884.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1324913.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9592186.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9592186.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMPZ02000391; KAF1324913.1; -; Genomic_DNA.
DR EMBL; AMPZ03000002; KAH9592186.1; -; Genomic_DNA.
DR EMBL; KL250941; KGB37884.1; -; Genomic_DNA.
DR RefSeq; XP_012797645.1; XM_012942191.1.
DR AlphaFoldDB; A0A094ZXI2; -.
DR STRING; 6185.A0A094ZXI2; -.
DR EnsemblMetazoa; XM_012942191.2; XP_012797645.1; MS3_0017240.
DR GeneID; 24593648; -.
DR KEGG; shx:MS3_00004204; -.
DR CTD; 24593648; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 4: Predicted;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..279
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 394..674
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 689..808
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 820..892
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1073..1167
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 968..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 128771 MW; 0C9376761293C049 CRC64;
MSVRRISKKF SVQSVEASEL KGAKLSLLGE STEAYAGIPT EVVDEDIEAE DEDNTQLNLF
EEDDKTLPPM SNWFGKLAAY TGGIEPTVGE TKQLKEKQTK SCDNKRLGTI LGVFLPCCQN
IFGILLFVRV GWITGVAGAF QTFLIVFLCC SCTMLTALSM SAIATNGKVP AGGSYFMISR
SIGPAFGGAV GILFYLGTTI ASAMYLVGAV EVFLKYIFPQ ASLFGDITSD AALFNNTRVY
GTILLFTVMC CVFMGIRFVS RFAAVSLAAV LISILCVYLG VFTVNPSRSP YVCALGGRLL
SQDFITVNGT AQCHKNTTGP IYEAYCNNRE IATEESCEFF NANNISYFPA MPGLTSKKFF
ENFFESHYRE KGEAYDSIDF PADRKYGQGP NIADVTSSFM LLLGIYFPSV TGIMAGSNRS
GDLTNPQKSI PLGTILAITM TSLVYLSSPL LFAAICDGSV MRDKFGESYG GILLVAAFAW
PHFWVILIGS CLSTIGAGLQ SLTGAPRLLQ AIAQDNVMPF LDVFKVITKR GEPLRAQLLC
YGIAQLGILI ASIDHLTPLI TMFFLMCYGF VNLASMLNGF LKEPSWRPRF RFYHWFLSFV
GLCLCIALMF ISSWYYTIVA WALAFAIYKY IEFRGASKEW GDATRGLQMS TAKQAILKLG
NKPIHTKNWR PQILVYLPLD ENFQARHDRL LDLVYQLKAG HGLTLVASIL EGDIIDRRND
MIAVKSHLSD LIQQHRIKGL AEVLVASTID EGMKNMAQCA GLGNLRHNTL MVSYPEDWRV
DCKSSGSKLS KFISTLRAAQ ACDIAMLVPK GIDSFPLSKG NQMIGNVDVW CIVHDGGLLL
LTSYLLMRNR VWRKCHLRIF VVATEDDDIV NLKKDMTKFM YDLRINASVE VVAMSTADIS
AYVTQRTASI EQRRALLMQM KISNVEARCD PQLIVDQHRK PSSVDINPAD IIKSNCSIDS
HKLLPAISAT STESSDQSPD HATNVTNTSS SDSASKEDTK PSNMKPDTES NNKSISNHSH
HCTVSFATGS NVAVSESDKS TNPKENDTNS ELNRGINEFT FSPSNPLTKL VQKAAKEAGS
KEEHLLNKAH PGKITRTQRR LHCAVRLNEL LRTHSSESDL VIVNMPGPSR TLGSEYYYMD
YIETLTDGLS RILLVRGTGR EVITAFSE
//
