ID A0A095A031_SCHHA Unreviewed; 837 AA.
AC A0A095A031;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Echinoderm microtubule-associated protein-like 1 {ECO:0000313|EMBL:KGB38784.1};
GN Name=EML1 {ECO:0000313|EMBL:KAH9593807.1};
GN ORFNames=MS3_00001852 {ECO:0000313|EMBL:KAH9593807.1}, MS3_07187
GN {ECO:0000313|EMBL:KGB38784.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB38784.1};
RN [1] {ECO:0000313|EMBL:KGB38784.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAH9593807.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9593807.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9593807.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; AMPZ03000001; KAH9593807.1; -; Genomic_DNA.
DR EMBL; KL251078; KGB38784.1; -; Genomic_DNA.
DR RefSeq; XP_012798544.1; XM_012943090.1.
DR AlphaFoldDB; A0A095A031; -.
DR STRING; 6185.A0A095A031; -.
DR EnsemblMetazoa; XM_035731049.1; XP_035588772.1; MS3_0014648.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR CDD; cd21931; TD_EMAP-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR049813; Elp-1-like_TD.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 169..239
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 522..563
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 643..676
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 801..837
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 56..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3..30
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 60..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 92753 MW; B1E5A121E527DA23 CRC64;
MHVELMNLEN AGLQDRVIDL EKRSAEQANE LACLRSSLAD CLRRLNLLES ARGMKLHSSQ
RPVLHNNGSN VTKTNSRTDS SYSSRRHTSS RNPTSTGHQS KNSRDSSLVV PHTTTTSTTA
RTRLKSPQSV RLSSSSTTLN NQAVGVSGGT NQTSSKETTY LPGDGILRFY IRGRPVNVYM
PTQIMHNYDL SIPLKAPDTT LKLEWIYGYR GRDCRNNLHY LPTGELIYFV AAVVVLYNIE
EQCQRHYLEH TDDVKCIAIH PDRITVATGQ SAGHDKQFGK PHVRIWSSVD LKTLKIIGLG
EFERSVCCLS FSKTDSGVKL CAVDEATDHV ISIWDWQKSR KITETKCSTE PITAVEFHPL
DDATLVTGGK GHLAFWTFDG CTLSKKMGIF ENGKQPIDKP KFILCLTFAE NGDLLTGDSA
GNIIAWKRGT NTVNQICQGV HEGGIFSLCL TNNGHLISGG GKDRRLVFFD AALNPTGHTE
ELTELYGAVR TITQGPGELL IIGTTKNMIL QAGPGMEISP LMFGHSEEFW SLAKHPQAHQ
FLTGGRDHLV ILWDSLSKQA IWSKEFTDAI HCAAFYPLQS VSITNGTMSP VNNNDNNIID
ETNNLDFNVS MMNSHDLLVV LGTSTGRWLV FNCLKQEIIA AHSDGLGEQI ECVAYSPDGN
YLALGSRDNV IYVYNVLERG YKYNRVGRCC GHSSFILHID WSVDGRFLRS VSGDYEILFW
TAFDCRQVVS PSTLRDLEWA SQTCTLGWEV AGIWPSDSDG TDVNACDHSP TADILATGDD
YGKVKLFKYP TNKPKAEFRA YNGHSSHVTN VTFLYDGSRL ISIGGKDTAV LQWEVCI
//
