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Database: UniProt
Entry: A0A095A3U8_SCHHA
LinkDB: A0A095A3U8_SCHHA
Original site: A0A095A3U8_SCHHA 
ID   A0A095A3U8_SCHHA        Unreviewed;       487 AA.
AC   A0A095A3U8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Serine/threonine-protein phosphatase 5 {ECO:0000256|ARBA:ARBA00020001};
DE            EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN   Name=PPP5C_1 {ECO:0000313|EMBL:KAH9596077.1};
GN   ORFNames=MS3_00001893 {ECO:0000313|EMBL:KAH9596077.1}, MS3_10561
GN   {ECO:0000313|EMBL:KGB41990.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB41990.1};
RN   [1] {ECO:0000313|EMBL:KGB41990.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA   Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA   Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA   Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
RN   [2] {ECO:0000313|EMBL:KAH9596077.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=31494670;
RA   Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA   Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT   "High-quality Schistosoma haematobium genome achieved by single-molecule
RT   and long-range sequencing.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EMBL:KAH9596077.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Stroehlein A.J.;
RT   "Chromosome-level genome assembly for S. haematobium.";
RL   Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:KAH9596077.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=35167626;
RA   Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA   You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA   Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA   Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT   "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT   explorations of molecular variation.";
RL   PLoS Pathog. 18:0-0(2022).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-5 (PP-T)
CC       subfamily. {ECO:0000256|ARBA:ARBA00008786}.
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DR   EMBL; AMPZ03000001; KAH9596077.1; -; Genomic_DNA.
DR   EMBL; KL252303; KGB41990.1; -; Genomic_DNA.
DR   RefSeq; XP_012801801.1; XM_012946347.1.
DR   AlphaFoldDB; A0A095A3U8; -.
DR   STRING; 6185.A0A095A3U8; -.
DR   Proteomes; UP000471633; Unassembled WGS sequence.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd07417; MPP_PP5_C; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041753; PP5_C.
DR   InterPro; IPR013235; PPP_dom.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45668:SF5; SERINE/THREONINE-PROTEIN PHOSPHATASE 5; 1.
DR   PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF08321; PPP5; 1.
DR   Pfam; PF00515; TPR_1; 2.
DR   PIRSF; PIRSF033096; PPPtase_5; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          10..43
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          77..110
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          189..469
FT                   /note="Serine/threonine specific protein phosphatases"
FT                   /evidence="ECO:0000259|SMART:SM00156"
SQ   SEQUENCE   487 AA;  55538 MW;  7F3A19A79983247D CRC64;
     MTLSTISDEA EALKEEANKF FKDGDYEKAI DAYTKAIEIR ETAVYLANRS LAYLRTECFG
     YALDDASKAI SLDSSYVKGY YRRASAHMAL GQYKEALADY ETVIRVAPSD KMAREKLTEC
     RKIIRRKAFE KAIAVEDQPS PLESFDLSTI TVESSYDGPH LEQDSNGKYF VTESFMLALM
     EHYKSQKVLH KKYAIIIMKD IFLFLRGLPS LVDIKVPEQS KFTVCGDIHG QFYDLMNIFK
     INGLPSKDNP YLFNGDFVDR GSFSVECIFT LFGFKLLYPD KFYLSRGNHE SEHMNRLYGF
     EGEVKSKYSS EVANMFTDIF NWLPLCHLIN ERILVMHGGL FERDNVTLDE IKKVSRNRQP
     DEGTIMCELL WSDPMEAEGR AHSKRGVGCQ FGPDVTKKFC KQNGLDYIIR SHEVKDEGYE
     VAHNGRCITV FSAPNYCDTM HNRGAFITLI GSNKPGEMSP MFTSFTAVAH PDVRPMAYVN
     PLLSMFM
//
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