ID A0A095A7B3_SCHHA Unreviewed; 511 AA.
AC A0A095A7B3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 36.
DE SubName: Full=Glycine receptor subunit alpha-3 {ECO:0000313|EMBL:KGB41604.1};
DE SubName: Full=Putative cys-loop ligand gated ion channel subunit {ECO:0000313|EMBL:KAF1320550.1};
DE Flags: Fragment;
GN Name=GLRA3 {ECO:0000313|EMBL:KAH9590476.1};
GN ORFNames=MS3_00003142 {ECO:0000313|EMBL:KAH9590476.1}, MS3_0011647
GN {ECO:0000313|EMBL:KAF1320550.1}, MS3_10138
GN {ECO:0000313|EMBL:KGB41604.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB41604.1};
RN [1] {ECO:0000313|EMBL:KGB41604.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1320550.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9590476.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9590476.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; AMPZ02000439; KAF1320550.1; -; Genomic_DNA.
DR EMBL; AMPZ03000002; KAH9590476.1; -; Genomic_DNA.
DR EMBL; KL251989; KGB41604.1; -; Genomic_DNA.
DR RefSeq; XP_012801384.1; XM_012945930.1.
DR AlphaFoldDB; A0A095A7B3; -.
DR STRING; 6185.A0A095A7B3; -.
DR EnsemblMetazoa; XM_012945930.2; XP_012801384.1; MS3_0011647.
DR GeneID; 24597283; -.
DR KEGG; shx:MS3_00003142; -.
DR CTD; 8001; -.
DR OrthoDB; 5393084at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18987; LGIC_ECD_anion; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF898; GLUTAMATE-GATED CHLORIDE CHANNEL; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Receptor {ECO:0000313|EMBL:KGB41604.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 25..511
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5039738354"
FT TRANSMEM 247..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 312..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 34..246
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 254..501
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT NON_TER 511
FT /evidence="ECO:0000313|EMBL:KGB41604.1"
SQ SEQUENCE 511 AA; 58454 MW; B8E895946593DFDF CRC64;
MHILNHQIIY FILCPLYIFY DSKCAVLDAS SIRDEIVETL FANYQSHVRP GELIRNTTVV
TVYISVSAIT SVDVRNMEYT IDMLLRQAWY DPRLAWDQIE KFKHYTKNIV SPVFKEKIWL
PDLFFRNGKE GRLHKMTCEN LLIRIQPNGE ILYSQKITMR MACQMELRTF PMDTQECDMN
IGSYGYTLEQ VSFVWRNISP VTLPENLQIS EFDPPEVVRA YDCTSGYSTS TGQYTCLNAT
FTLQRQLGYW LASTYIPNIL IMVVSWLNFW VSLEAIPARV NLSLLTLLGV ITQSTSYASS
LPRVSYIKAI DIWTIACITF NSGVLLEFAI ASHLARRQKV SEWQVEVRKL VRRELARWCS
ACQLQYAQRG PSALSAYSAS SRPNEKVGEY INSVAAAAFA IQNSPVLERP SPQMSVRLTK
SGLMSMANIK SGKPDKVSKG VFYELVTNDS ALTALDTTQK DALLPTNEPQ RVKKPASMSK
IDSYSRFVFP ACFLLYNCFY WLYYLVIVKH K
//
