ID A0A095AGY5_SCHHA Unreviewed; 891 AA.
AC A0A095AGY5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 4 {ECO:0000313|EMBL:KAH9588570.1, ECO:0000313|EMBL:KGB33176.1};
GN Name=FGD4 {ECO:0000313|EMBL:KAH9588570.1};
GN ORFNames=MS3_00005932 {ECO:0000313|EMBL:KAH9588570.1}, MS3_01346
GN {ECO:0000313|EMBL:KGB33176.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB33176.1};
RN [1] {ECO:0000313|EMBL:KGB33176.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAH9588570.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9588570.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9588570.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AMPZ03000003; KAH9588570.1; -; Genomic_DNA.
DR EMBL; KL250536; KGB33176.1; -; Genomic_DNA.
DR RefSeq; XP_012792957.1; XM_012937503.1.
DR AlphaFoldDB; A0A095AGY5; -.
DR STRING; 6185.A0A095AGY5; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 92..281
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 310..412
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 445..496
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 586..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 101883 MW; D5506F6B65F8C4DA CRC64;
MSGGCVHVSI KLDILHPDYL CDLVNKTPES EIRGCKNVFG ESVTKGSIFL DALDFQRNKI
KNLLNETLKE KLSTSNKGLL STAQKDLDAM EKKRKIARSV YDEMLQYGKR LLECIRILKD
VNDELQNVSS LRCNSVINGM FKDIPSLFKV HEHLTESFDS CEAEDIELPS TFTSDKEMQI
LNIYKSFLCR YAVNFKTFSE MYSTNEELQN ICKGIVAKSQ YQEQRIQNVP GMFYGVSTAL
PRYKDLIYRL KGTMLPSDPE YTNVTKAWNF IKDLLDRSEQ EIILQEKMLN AREALGKLDG
LRVKYTQIPL LHLEGPAKKL PRRSIHRRLL DRYLFLFSEY LVMTESPNAV GRYQVKSEIG
LAGMTLCEVK DDEEINVEHC FRIKAKELCV EVAFSNDDEK QLWWRELQQA IDCECNKPNS
NCFNEKKSIM SANNLGEVAA QWVKDESSTM CTNCCTEFTT LNRRHHCRAC GKLFCGSCSA
YKAPLESCGG KYERVCVVDY YLLNKNFKPP KPKIMEAILR RVDKQQPLQP LRTGFLMWSH
FNNSWSTKSP IRLPKSSVQY RSVDTSSEIR KELLRDIGPF NSSSKFACKN SSTDPVDNHH
DSNTKSTSNS LPHINNRSFD SSINIESTNH KSSSACLSRL FCVLQTDTSF EFYAARADTR
AVDKITVIGL RLFYLDDNFN DTFSNHNGNL STIQQPTLHT KARSFDNSSN VNKDFPENTI
GSFRREYSRL YRQGNPIYRN CKPPPRDRNI FDHGFSSETS SLSDVTSLSK SYIKPSSVST
LEADRLSNRS TQSCRERSSK ENHKNSLCNF SGDQSNDDDG IVTNSEIIKH VETISPEILS
LLRNNLGFLL LPLNTDRPAH YFEATTVEIR TQWINSIRRV CIDFMSSPPS R
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