ID A0A095AIV1_SCHHA Unreviewed; 441 AA.
AC A0A095AIV1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Polycystic kidney disease 2-like 1 protein {ECO:0000313|EMBL:KGB33961.1};
GN ORFNames=MS3_02150 {ECO:0000313|EMBL:KGB33961.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB33961.1};
RN [1] {ECO:0000313|EMBL:KGB33961.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR EMBL; KL250580; KGB33961.1; -; Genomic_DNA.
DR RefSeq; XP_012793727.1; XM_012938273.1.
DR AlphaFoldDB; A0A095AIV1; -.
DR STRING; 6185.A0A095AIV1; -.
DR EnsemblMetazoa; XM_035732604.1; XP_035586961.1; MS3_0017626.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..125
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 134..353
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 441 AA; 51076 MW; EC958449FBBF5186 CRC64;
MFNEDKEAYG ISWAKFEGND KSNNSAPEFV YQNSSQLKGY PYLGQITWYS GGGYVHLLRG
SKDEMLDRMR FLNQTHWIEF STRAIIVQFT VYNPNINLFA IITALIEMPG IGAMIPSYRI
ETANLFGVLG SKTKLAQITS QALFAFILFC YLIKELRSMF RQRLKYFTKF WNFVELFIIC
GSIAAIAAYI YMILSTKLSI EEFSRTHGNI YMNFQLLAYW NENLTYLTAI ICFFAMLKLV
YLFRFNQRVG LLGSVLKYAA TDLKYFCFIF LVVFSAFVLV FYLLYNDTLS GFKTILNAIE
TSMQIILGKF DFTSMYERQM VLGPLLFAAF SLCVVFVMVS MFIAILDESF QRVLKDLSLQ
SDDHEMTQFI AIQFIQSIGL DRTTWGKNFI KNVNTQQQEP IYDPESESSK HVAQLKSLMN
EFLEHVQQNL ITEERKPVDS K
//
