ID A0A095BW86_SCHHA Unreviewed; 956 AA.
AC A0A095BW86;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Nuclear hormone receptor FTZ-F1 beta {ECO:0000313|EMBL:KGB33228.1};
DE SubName: Full=Nuclear receptor sub 5 group A member 2 {ECO:0000313|EMBL:KAH9584915.1};
GN Name=NR5A2_1 {ECO:0000313|EMBL:KAH9584915.1};
GN ORFNames=MS3_00006348 {ECO:0000313|EMBL:KAH9584915.1}, MS3_01388
GN {ECO:0000313|EMBL:KGB33228.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB33228.1};
RN [1] {ECO:0000313|EMBL:KGB33228.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAH9584915.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9584915.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9584915.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMPZ03000004; KAH9584915.1; -; Genomic_DNA.
DR EMBL; KL250538; KGB33228.1; -; Genomic_DNA.
DR RefSeq; XP_012792998.1; XM_012937544.1.
DR AlphaFoldDB; A0A095BW86; -.
DR STRING; 6185.A0A095BW86; -.
DR EnsemblMetazoa; XM_012937544.2; XP_012792998.2; MS3_0017019.
DR GeneID; 24589145; -.
DR KEGG; shx:MS3_00006348; -.
DR CTD; 24589145; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07167; NR_DBD_Lrh-1_like; 1.
DR CDD; cd06930; NR_LBD_F2; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5-like.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24086:SF25; NUCLEAR HORMONE RECEPTOR FTZ-F1 BETA; 1.
DR PANTHER; PTHR24086; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KGB33228.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 376..454
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 616..855
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 861..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 956 AA; 101789 MW; 3E5BDB5C2B1D2784 CRC64;
MAASEVTSPT DIQDDLKNES LEATVSLDKL IMGGAPKSSG SVSTSDDHVP ATTYVTIHLP
DGTQGSTLSQ QKLQELIMHL SQSGQIQLRE DSKIVIDLKF SGKSGDQGVQ TKLENSSLQH
SAVSSGTASQ IQTIASSIPH RVLQVGSSGS DGVQIVRTIP SFVSSTTQII SFPTVATQQP
VAAQSSNPRQ QIQQQPTYIL VPAAQLAGGG ENQVFASTPI RAVTAGHTML RTSGIGINNN
QNINTSSVNL GSTDRSIILV QQPVAGTSIH VGSTGSIVPG SSSGSGTTLV PLRQLGVSTC
GGNGLVSSAG STRLIGSNVG IELFSSTVGS RSSQGQGGSM GLVTISANAG VSGSSSSGTP
QRESTWQQYV KQFTKLGPCP ICGDKISGYH YGIFCCESCK GFFKRTVQNA KRYACHRPNA
SSRCEINVAS RKKCPACRFL KCVDKGMRIE AIRSDRTRGG RSMYPGSRYL RQIAARVSGT
HSAPGLGLSN SAMEFSTSDL DGSMLRGLTD QSIMSDDADQ LSCSVVGLAA HTLGPDGLPA
SEDAGGGVYL DPGVLGTHDN DDEEIDSGSL RVEPNILECG SGIVGGTNFS TNVSPYLGRQ
VIIGGSNESI PRTREQLPKI IRDILLVEET IEAEPEDSLE IDAAVASETA APEGVSDDEA
AVYRALLNLA DQRLYRTVRW SRALPDFSIL DTDDQILLIQ NCWADLLCLD CCWRSLPTPS
EIRLTSSKCI NLEAAREMGA EEIVERILQL TQSLTRLQLD IVEYACLKVI VLMQPDLNNL
KASSQVRSYQ ESVRRLLMDY VTKSSPDIND KFNKLINRIP ELRKTSQAAR LMLVDLDLSS
YLSTNSLLME LLRSDIQRYT PNNGSHNSTE STTAVSMQGS TNSGIKTVSV TLGADTAENQ
GENTTVTMVP SSGVTDLLSL PNHTTITTVT ESRLDETITS NSNTSLTTSE VDVISK
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