ID   A0A095BXS8_SCHHA        Unreviewed;      1163 AA.
AC   A0A095BXS8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Cyclic nucleotide-gated cation channel {ECO:0000313|EMBL:KGB33883.1};
DE   Flags: Fragment;
GN   ORFNames=MS3_02075 {ECO:0000313|EMBL:KGB33883.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB33883.1};
RN   [1] {ECO:0000313|EMBL:KGB33883.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA   Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA   Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA   Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KL250575; KGB33883.1; -; Genomic_DNA.
DR   RefSeq; XP_012793652.1; XM_012938198.1.
DR   AlphaFoldDB; A0A095BXS8; -.
DR   STRING; 6185.A0A095BXS8; -.
DR   EnsemblMetazoa; XM_012938198.2; XP_012793652.2; MS3_0018759.
DR   GeneID; 24589774; -.
DR   KEGG; shx:MS3_00003813; -.
DR   CTD; 24589774; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45638:SF4; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        154..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        259..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          539..660
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   NON_TER         1163
FT                   /evidence="ECO:0000313|EMBL:KGB33883.1"
SQ   SEQUENCE   1163 AA;  132818 MW;  02B9F0001CE41356 CRC64;
     MDDTHVSTSD DSVITLDNSK QSNWFICKED KTDENITTYE KQNHIRQRLS GENYSNTQPN
     VPLLYNGPYS YSDPKEKHDM IQGINKTSIS RTPSSLQNKS QKLRKSNWNS ALLYFNPSGR
     IVHSWCGVIS IVFMYHLWVI IYRFAFNEIN QQTVIFWLTL DYFADLLYLI DMTISLRTGF
     LEDGVMQFDG MKMRSHYLNS SRFYIDCLSL LPLDFLYLSI GFKSILRIFR LCKVYKFWQF
     MDRAERHTNY PNLMRSTKLL LYYLTFLHWN ACVFQLINST ADTLFMTSLT QSPTSGTTII
     DGSRTNIPNL SGTHTNHHTT NINNSHRNNN NQNINHSSNR SNLSENIINN GSSLLLRSNH
     SLSNIDNETI FPTATSASVK LTNTDVGSLI TMSPNKIQLT PDHHDGYEYL HAFYWSMLSL
     FPVGGFPTPK CPIAYFYLIC EGVIGMFLMA TVLGHVSNIV TNVSAAQKEF QARLDSVKNY
     MTLRRVPASL QERVINWFDF LWYTNKITDE EKVLRNLPYK LKAEIAIHVH LNTLKQVEIF
     QDTEEGFLSE LVLKLRVVLF APGDYVCRKG EIGKQMYIVN RGKLHVLGDD GHTVLATLHA
     GSYFGELSIL NLGNNGNRRT ASVRSLGYSD LFCLSKSDLW KVLKEYPNAR SKLEADAYRK
     INQYQNIPQQ NMKDFPIKSI PFEKKVMNST DPMNYTGYSA PAHNSTHLRN NNLTISQNSH
     SQLDMNSNNE CLVRVSNSDG SDGYGSDPSR CSAFLPTPQR SPTPSAIMVM NNSDKTHIAS
     NNSPFPQLNP TIFNVTSQSQ PVYENRSSSV PTTVSDSLGN FTALCSNENE QVCNCLIAES
     NKCPRLKLYQ NNLIPFGKQR HLSMPTNLFP TDDSFYHPNS SQLKESNVKS TPIALHSGVV
     ITDFHSNQWK EVENEKLFRK YCHFDCSMKG KQTITSNLDS SNRDGTVNGK RVIPIICFEK
     ASTPSISEAT ISEDEQEYQA VYKHTSQPSS SSCIIKAPSY SSSMLIPEPT HGKYCTHLKI
     PKHKTPNWTA RRPPWPYKTC SHHYKSPGIF KTGHSSNHSI EDNSMVNTTH GYKHNKTNHE
     LIEQLSHLIY RINKLENENY ILQNSLFNQS NSIMIQQQQQ HQVQPLLPQQ KWSPTVNLTR
     QYSLPIKSTN VYQHFQDYLK IPN
//