ID A0A095BZU6_CRYGR Unreviewed; 945 AA.
AC A0A095BZU6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Nuclease domain-containing protein 1 {ECO:0000313|EMBL:KGB74305.1};
GN ORFNames=CNBG_0143 {ECO:0000313|EMBL:KGB74305.1};
OS Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB74305.1, ECO:0000313|Proteomes:UP000029445};
RN [1] {ECO:0000313|EMBL:KGB74305.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB74305.1};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2] {ECO:0000313|EMBL:KGB74305.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB74305.1};
RX PubMed=29507212;
RA Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT "RNAi is a critical determinant of centromere evolution in closely related
RT fungi.";
RL Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR017179}.
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DR EMBL; CP025762; KGB74305.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A095BZU6; -.
DR STRING; 294750.A0A095BZU6; -.
DR VEuPathDB; FungiDB:CNBG_0143; -.
DR HOGENOM; CLU_005966_1_0_1; -.
DR OMA; EKTCCTV; -.
DR Proteomes; UP000029445; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:InterPro.
DR CDD; cd00175; SNc; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR12302; EBNA2 BINDING PROTEIN P100; 1.
DR PANTHER; PTHR12302:SF2; STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00565; SNase; 2.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 4.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; Staphylococcal nuclease; 5.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50830; TNASE_3; 4.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017179};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..161
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 187..361
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 387..528
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 557..690
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 763..823
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 272..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 103893 MW; E01F51179FC28042 CRC64;
MTTRAIVKYV MSGDTVVVRP KEAPEKGKVP KERILHIAGI QAPRLGSLSR EDEPHAFSAR
EYLCSLLLGK EVAFTITHTI ESSAGPNREF VSLFIAPAGP GLPPQDVASL ILAQGWAKLR
DGVGEGDEAV RRLGAEEAKK RENLRVIEAQ AKSEGKGIWD EQPENQRTVA FQMPNDPQAF
IADHKDEEID AIVEQVRDGT QLRVRLLLDE HNHQFINLVL AGAKSPRSGN PRDGEASSGE
AWGDEAKYFT EIRMLQRHIK VRLLSAPASL GASPLQQTQP SKGSGVGLTG TNGLPAPSTG
STVIIGTAIH PKGNFAEFLL AAGLAKVVDW HVGLLAPYGG LDKLRAAEKA AKDKKQGIWE
NYQPQRASAT NGAASAAPTA ATTTKGADFE ATVVRIWGSD QLSVVEKGEG GKERRVQLSS
VRGPKGVDAK QTYWANEAKE FLRKRLIGKN VNVHVDYVKP KEGDFEEREC VTIRYGNQNN
NIAEQLIEKG LATVLRHRRD DEDRSLELDK LILAEQTAQT EGRGVHSTKD VSMPRIVDAS
ERASMASSYL PQWKRQGRHN AVVEFVSAGS RFKLYMPKEH TKVTFVLAGI RAPRTARNAS
EKPEPFGAES LKFASKYLQR DVEIAFDSTD RSGGFIGTMY TSGGVNVAVE LAREGLAFVH
ERSAELLPFG KELLAAEEQA KKEKKNIWSA VQEEEAATAA SVDESSALPV DYKDVYISSV
KESEPFTFSV QILEKDSVAA LEKLMSDFSL HHRQASAATS SFTPKAGDLV SAKFSKDDRW
YRARVKRASA IKKEAQVYLI DYGDEETVPF SKIRPLDEKF KSLPGQAKEA RLSFVKLVPR
SSEYGPEAYR RFEYLTEGLK LIANIDQREG NLLHLRLIDP ADPNIKEDPL ACLNADLVRE
GLATIDKSCK YLSSYPQIVR KLQDAGEGAK ADRLGIFEFG DVSED
//
