ID A0A095CE51_CRYGR Unreviewed; 528 AA.
AC A0A095CE51;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Homoserine O-acetyltransferase {ECO:0000313|EMBL:KGB78730.1};
GN ORFNames=CNBG_4568 {ECO:0000313|EMBL:KGB78730.1};
OS Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB78730.1, ECO:0000313|Proteomes:UP000029445};
RN [1] {ECO:0000313|EMBL:KGB78730.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB78730.1};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2] {ECO:0000313|EMBL:KGB78730.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB78730.1};
RX PubMed=29507212;
RA Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT "RNAi is a critical determinant of centromere evolution in closely related
RT fungi.";
RL Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MetX family.
CC {ECO:0000256|ARBA:ARBA00006886}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP025760; KGB78730.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A095CE51; -.
DR STRING; 294750.A0A095CE51; -.
DR VEuPathDB; FungiDB:CNBG_4568; -.
DR HOGENOM; CLU_028760_5_0_1; -.
DR OMA; SYLHYQG; -.
DR Proteomes; UP000029445; Chromosome 2.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR HAMAP; MF_00296; MetX_acyltransf; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR008220; HAT_MetX-like.
DR NCBIfam; TIGR01392; homoserO_Ac_trn; 1.
DR PANTHER; PTHR32268; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR32268:SF11; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF000443; Homoser_Ac_trans; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KGB78730.1}.
FT DOMAIN 60..245
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT REGION 249..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 154
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT ACT_SITE 438
FT /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT ACT_SITE 467
FT /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
SQ SEQUENCE 528 AA; 57386 MW; 5B27A622ABCF4CB8 CRC64;
MSDNTLIPQQ VPDTNPYASL ISQQIAIIPS FTLESGVTLN NVPVAYKTWG KLNKKADNCL
VICHALTGSA DVEDWWGPLL GLNKAFDPTR FFIFCANVIG SPYGTISSVT TNPETGKPFG
PEMPGSSVKD DVRLHYIVLK SLGVKSVAAV VGGSMGGMTV LEYPLNTPPG FVRAIIPLAT
SARHSAWCIS WGEAQRQSIY SDPDYKDGYY YEIEEEEGKV DLARQPARGL AAARMAALLT
YRSRDSFESR FGRRSGGGKS SVPKGGVRIM GGQETTDPSV PSASDLAAKS PSWRAWREHN
DGHRSAGTRP VSRSGSEGPA RGEGDAAQVE IVKTQEVKAN GNKIGTGGEA LPKIFSAQSY
LRYQGDKFTG RFDANCYIHI TRKLDTHDLS TPSRDTSMSS LSSGLRSSPD PTEEELDARL
IHALSLEPPA LVIGIESDAL FTTSEQRELA AGIPDAELVV IPSPDGHDGF LLEFEAINGW
IEGWLKRKMP EFYEERVINA EDYVQGEEGF GIKKESVFGE AEADITRW
//