ID A0A095CE75_SCHHA Unreviewed; 920 AA.
AC A0A095CE75;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA helicase MCM9 {ECO:0000256|ARBA:ARBA00041085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=MCM9 {ECO:0000313|EMBL:KAH9588520.1};
GN ORFNames=MS3_00005896 {ECO:0000313|EMBL:KAH9588520.1}, MS3_0011892
GN {ECO:0000313|EMBL:KAF1320784.1}, MS3_09551
GN {ECO:0000313|EMBL:KGB41053.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB41053.1};
RN [1] {ECO:0000313|EMBL:KGB41053.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1320784.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9588520.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9588520.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; AMPZ02000439; KAF1320784.1; -; Genomic_DNA.
DR EMBL; AMPZ03000003; KAH9588520.1; -; Genomic_DNA.
DR EMBL; KL251700; KGB41053.1; -; Genomic_DNA.
DR RefSeq; XP_012800815.1; XM_012945361.1.
DR AlphaFoldDB; A0A095CE75; -.
DR STRING; 6185.A0A095CE75; -.
DR EnsemblMetazoa; XM_012945361.1; XP_012800815.1; MS3_0011892.
DR GeneID; 24596723; -.
DR KEGG; shx:MS3_00005896; -.
DR CTD; 254394; -.
DR OrthoDB; 1342948at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000313|EMBL:KGB41053.1};
KW Hydrolase {ECO:0000313|EMBL:KGB41053.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633}.
FT DOMAIN 305..516
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 684..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 104304 MW; 0E8BD0FB79C4EA8B CRC64;
MTMKSESIIS LFSEYLLREH RSDICKLSLL LPSEPHQSII VHFNNLCEFN SIFSELILSK
PEETLNLLNK SVYQVIQSKK VDNPKQLLDN IQQNIHIRLT ALPIIPEVYK NHIPTSIDTG
KFIALRAIVS RVGPVQVIQS KVQYYCIKCG YTFSVYANFE NFYAIKPPRY CPNRQQSCNS
MNLKCVSSNS QFYAKNYQEI RVHEQFDCLT VGVMRRSMCV CIEDDLLECV KPGDEVVING
VVTRRWRCTK EGSPCETFTY LKANYIENLT ELKAGGGPSH ISHERALEFK VFWNKYTNFS
SALEGRNILL RSICPEVYGM YLIKLSLALM LASAPEWHST SGETTSVDEL STHIRGNPHI
LLIGDPGTAK SVLLRGCTSL CDRAVLTTAT GTTAAGLTAT AIRDSTGWTL DAGALVLADG
GLCAIDEFTA LHGVHRAAVH EAMEQQTISL AKAGLMARLN CRCSVLAAAN PSPNSILHGN
EDYGLPTPLL SRFDLIWRLV DPVDSLEWDR RIANFILDLD QPTSFSTNQE ITKHHLWSKN
DLKEYFVWIR DRFTPQLSME AANLLQRYYV WQRSQMSNFC NDSLAGAFSR RTLRLLESLV
RLTKAHARLM CRNEATVEDA IVVIYLVDCS LYSTSSINDN QSHLNNSSLS KFISPELIVS
MNIPENASVD YLQIEKLVMS TLNNNNNNNN NNNNNNNNCS KNIDNDNGNV YLNRFKQDHS
NTYRKVQLEP LLSSTQLITN NNDSLKKYTQ EDSRQRQSLP SYKRTFHHDN NNACSPSSVI
QNNNNNNNDD DDLSMIPSTK SFKWTPLNNS IDIDDNTTTT TDINTTDNQI FNNNNINMNK
PLWNKHLSSN SFNISNNDLS MSMDTFNNTI QNIQYSMDNK DKNNNDDDDD IFTFGFNMLM
TNSENILKKH LKSEDFEIDL
//
