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Database: UniProt
Entry: A0A095CGL0_CRYGR
LinkDB: A0A095CGL0_CRYGR
Original site: A0A095CGL0_CRYGR 
ID   A0A095CGL0_CRYGR        Unreviewed;       783 AA.
AC   A0A095CGL0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN   ORFNames=CNBG_5338 {ECO:0000313|EMBL:KGB79500.1};
OS   Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS   (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB79500.1, ECO:0000313|Proteomes:UP000029445};
RN   [1] {ECO:0000313|EMBL:KGB79500.1, ECO:0000313|Proteomes:UP000029445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R265 {ECO:0000313|EMBL:KGB79500.1};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2] {ECO:0000313|EMBL:KGB79500.1, ECO:0000313|Proteomes:UP000029445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R265 {ECO:0000313|EMBL:KGB79500.1};
RX   PubMed=29507212;
RA   Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA   Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT   "RNAi is a critical determinant of centromere evolution in closely related
RT   fungi.";
RL   Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication.
CC       {ECO:0000256|RuleBase:RU365058}.
CC   -!- SUBUNIT: ORC is composed of six subunits.
CC       {ECO:0000256|RuleBase:RU365058}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365058}.
CC   -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC       ECO:0000256|RuleBase:RU365058}.
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DR   EMBL; CP025764; KGB79500.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A095CGL0; -.
DR   STRING; 294750.A0A095CGL0; -.
DR   VEuPathDB; FungiDB:CNBG_5338; -.
DR   HOGENOM; CLU_012774_1_0_1; -.
DR   OMA; CSFHERL; -.
DR   Proteomes; UP000029445; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 2.30.30.490; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR   PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51038; BAH; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU365058};
KW   DNA replication {ECO:0000256|RuleBase:RU365058};
KW   DNA-binding {ECO:0000256|RuleBase:RU365058};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW   Nucleus {ECO:0000256|RuleBase:RU365058}.
FT   DOMAIN          75..223
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   REGION          102..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..285
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..314
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..338
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..642
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   783 AA;  86156 MW;  CC64D86F39F4F33B CRC64;
     MTIPFTPRRS TRGQVFTPSP FPTPRISHSD TKFTWLSAAS TPRLSPGGSK TRTHYTAFSK
     VFTKGGKKNA APKMTKFTVG DGVLVNVEGG NDGVAVLIDL WEEERSEDDS EEDEEDGEEE
     EKGLLMMAEV HWLLRRQDLP DVRRNFKVDD NEVLLTASAT RRVTATIPIS LLDDTVPVLS
     RTEFREKYPE EKSHYRGWAY VREGIYWCQR AYDRFAKGQN CWKIDIEEWK EAGKRERGWA
     VPIPKEKEEQ PQEPDIESSD ESDEGSEARI GEESDGDEES EGESEGLADS VSKKRKRSTK
     TVATHAKRGR KPVSASRSKV PSRSKAIPKS RKATKKPHPT RPSTFLPTDI IAPELLPTDP
     FERALRMLHV GATPESLPCR EEEFVDVLSK VEEGVESGGG GCLYIAGVPG TGKTATVHAV
     VKELKRKAED GEIPPFSYVE INGLKIPTPQ HAYTVLWEAI SSSKGVSAKT ALKGLENHFG
     KKGGGARGPR GHTFVVLMDE LDQLLTSKQD VVYNFFNWPT MRDSQLFVIA VANRMDLPQQ
     LAAKIKSRLG LQTILFEPYD RAALISIVQS RLIPHPLMPS QDPKVLLPDA IALAAMKMAG
     TNGDARRVLD ACRRAVEVAL ENKSKPPSAL PTAPPPQPGP QPVSAKAMST VLQAMSSSPT
     TKFIQACSLQ QKLMLAALVR CVRREGVAEI AWKNIRNDHD ALMRSLAFDT SEQGGREVAP
     NLLSNSELAL VLTSLTSSHA LVCSADISKG VDERKVALGM EIGEVGRVLM NEGDSWRKAL
     AGV
//
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