ID A0A095CHI7_CRYGR Unreviewed; 708 AA.
AC A0A095CHI7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=HSF-type DNA-binding domain-containing protein {ECO:0000259|SMART:SM00415};
GN ORFNames=CNBG_5440 {ECO:0000313|EMBL:KGB79602.1};
OS Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB79602.1, ECO:0000313|Proteomes:UP000029445};
RN [1] {ECO:0000313|EMBL:KGB79602.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB79602.1};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2] {ECO:0000313|EMBL:KGB79602.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB79602.1};
RX PubMed=29507212;
RA Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT "RNAi is a critical determinant of centromere evolution in closely related
RT fungi.";
RL Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|RuleBase:RU004020}.
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DR EMBL; CP025761; KGB79602.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A095CHI7; -.
DR STRING; 294750.A0A095CHI7; -.
DR VEuPathDB; FungiDB:CNBG_5440; -.
DR HOGENOM; CLU_350548_0_0_1; -.
DR OMA; INDPHRT; -.
DR Proteomes; UP000029445; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR10015:SF457; HSF_DOMAIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 184..289
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00415"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 77378 MW; 658F85BCF818AB15 CRC64;
MALFQPSSYP PPSASPFGRL NLPHHTSSHH QHHDSSGSSH HPNNSPPVSE GWLPKLPVSQ
SRAYVSPDPS PREEDAFLPH WGHHHPNVNQ HAQSHSQSQQ PKLPVPVLAA YSTPPSMPKM
QFPNRRGLLT SSDMPTGSGS VGDGGRHTGM GEGDIMPEMD PFYNPTTPPP EQLSKKKKKK
AEGKQPTFLI KLYSLLSQPE YSHIIRWDEA GESVIIENPE ELADKILPVV YRQSRFASFS
RQLNIYGFNR KLSLRNVEKG ICDPDASSWS HPFLRRDSTK EQILSFKRRV PPRPSQAQKR
LMLMGLSVGI NASHAPVSNG DDQVSPTSSE HSLDWQSPPD PYQHHILPDV DEESPFVFPT
RHYFSLAGYG SVGYEGWKQS GAAAGSVQCV ASQGEEGFSP TTIHYDYGTP PDRDGLNGFM
ASSQVRHGGS LKGLAIDNPH SSHPFNHLTQ QQVKPSFPVP CQPLPLSLLG QKLPTDLIPQ
SAPANTGSFP IPIRVTQQHV RTRSVQGEPL SAMLFSPFDG ELGEVPEPAG FSQNLNGTES
HGHQPGTMDP PVIPAAPAYN PSDPSTCARR GFIDFNIAGV SDPLPFNPMP TYARLATSPH
SLPTDMSPLH QQQTASPSEL MGQSISSALS DDSPKMLPPG TYQSGFSLPV CQSPYLQKRI
SSLNPPARAR SNPIPNLNSN AGFEKSPLMN NEHIVRPCPI TQTEQVQL
//
