ID A0A095DAY9_CRYGR Unreviewed; 924 AA.
AC A0A095DAY9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 2.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Importin beta-2 subunit {ECO:0000313|EMBL:KGB78071.2};
GN ORFNames=CNBG_4158 {ECO:0000313|EMBL:KGB78071.2};
OS Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB78071.2, ECO:0000313|Proteomes:UP000029445};
RN [1] {ECO:0000313|EMBL:KGB78071.2, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB78071.2};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2] {ECO:0000313|EMBL:KGB78071.2, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB78071.2};
RX PubMed=29507212;
RA Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT "RNAi is a critical determinant of centromere evolution in closely related
RT fungi.";
RL Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000256|ARBA:ARBA00038423}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP025764; KGB78071.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A095DAY9; -.
DR STRING; 294750.A0A095DAY9; -.
DR VEuPathDB; FungiDB:CNBG_4158; -.
DR HOGENOM; CLU_008136_1_0_1; -.
DR OMA; AQEGAMS; -.
DR Proteomes; UP000029445; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
FT DOMAIN 31..103
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 335..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..391
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 924 AA; 102309 MW; DFED61E9B6ECB889 CRC64;
MAWQPSEQGL QEVLGMLRDT SSVDSEVQRN VAQRLEQLRF VPDFLAYLAH VLIHCTGEQD
SHRAVAGLLL KNSLNQRSGP TTNENDARAM AYVKNTVLTG LADPDQIVRQ TVGTVIMCLI
SNEDVGAWPE ALDALTKGMG STDPNVVEGS FNTLQKICED APHKLDFQVQ GRDLLDHLVP
QFIEFTNHSV DKVRLYALQI LQSLLSIGVA AVTANIDNYI RALFNKASDP SSDIRKSVCA
SLGLILGSRP DKLVPEMSNV VDYIAFCTQD EDETVALEAS EFWLTFAEDA SLKDQLRPYL
PKIAPLLLNK MVYSDYDIAV LDMDEYDEDV ADKETDIKPR NYSSKVHAAH ETNDPSSSKG
PGFSREAADR AFEEEDEEDD EDDEDFFDDE DGTGEWNIRK CSAATLDVLA VSFGAELLEI
LLPHLRDKIF DTEWQQRESG VLALGAIAEG CIAGLEPHLP QLVPFLLRSL EDKKALVRSI
TCWSLGRYAS WIVQVNPEDK TQYFIPTMEG LLRMVLDHNK RVQEAGCSAF ATLEEEAGTE
MAPFLEPVLR NLTYAFSKYQ QKNLLILYDA IGTLADSVGD ALGQPGYLEI LMPPLIDRWQ
RLGDNDPDLV PLLECLSSVS IAASQSFTAY TSPVYQRCLN IIHTTLQQYS AFEQDPDNVD
EPDRTFIVVA LDLLSGLVQG MGEAIHPLIS EGQPPLLHLL ALCLTHYEPP IRQSAHALLG
DMAISCFPIL KPVVPQILPS VLEQIVVEPP VDCISVCNNA AWAVGEVALQ FNNDSAALEP
FVPALIQRLI PILLSSKSPK SLSENAAVTI GRLGLVCPAL VAPELPNFAQ AWCTALWEIK
DNDEKDSAFR GLCMMISANP EGIQSSFVWF CNAICKWQHP SAQLDEMFRT ILQGFKNGLG
AQWDAQMSNF PPVIRQRLAE RYSV
//
