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Database: UniProt
Entry: A0A095SSY8_9FLAO
LinkDB: A0A095SSY8_9FLAO
Original site: A0A095SSY8_9FLAO 
ID   A0A095SSY8_9FLAO        Unreviewed;       360 AA.
AC   A0A095SSY8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Aminomethyltransferase {ECO:0000256|ARBA:ARBA00012616, ECO:0000256|HAMAP-Rule:MF_00259};
DE            EC=2.1.2.10 {ECO:0000256|ARBA:ARBA00012616, ECO:0000256|HAMAP-Rule:MF_00259};
DE   AltName: Full=Glycine cleavage system T protein {ECO:0000256|ARBA:ARBA00031395, ECO:0000256|HAMAP-Rule:MF_00259};
GN   Name=gcvT {ECO:0000256|HAMAP-Rule:MF_00259};
GN   ORFNames=LG45_11185 {ECO:0000313|EMBL:KGD67677.1};
OS   Flavobacterium aquatile LMG 4008 = ATCC 11947.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1453498 {ECO:0000313|EMBL:KGD67677.1, ECO:0000313|Proteomes:UP000029554};
RN   [1] {ECO:0000313|EMBL:KGD67677.1, ECO:0000313|Proteomes:UP000029554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 4008 {ECO:0000313|EMBL:KGD67677.1,
RC   ECO:0000313|Proteomes:UP000029554};
RA   Gale A.N., Pipes S.E., Newman J.D.;
RT   "Whole Genome Shotgun of Flavobacterium aquatile LMG 4008.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. {ECO:0000256|HAMAP-Rule:MF_00259}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-
CC         aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-
CC         methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-
CC         lysyl-[protein] + NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475,
CC         Rhea:RHEA-COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001708, ECO:0000256|HAMAP-
CC         Rule:MF_00259};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H. {ECO:0000256|HAMAP-Rule:MF_00259}.
CC   -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000256|ARBA:ARBA00008609,
CC       ECO:0000256|HAMAP-Rule:MF_00259}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGD67677.1}.
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DR   EMBL; JRHH01000004; KGD67677.1; -; Genomic_DNA.
DR   RefSeq; WP_035127080.1; NZ_MUGQ01000007.1.
DR   AlphaFoldDB; A0A095SSY8; -.
DR   STRING; 1453498.LG45_11185; -.
DR   eggNOG; COG0404; Bacteria.
DR   OrthoDB; 9774591at2; -.
DR   Proteomes; UP000029554; Unassembled WGS sequence.
DR   GO; GO:0004047; F:aminomethyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 4.10.1250.10; Aminomethyltransferase fragment; 1.
DR   HAMAP; MF_00259; GcvT; 1.
DR   InterPro; IPR006223; GCS_T.
DR   InterPro; IPR022903; GCS_T_bac.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   NCBIfam; TIGR00528; gcvT; 1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   PIRSF; PIRSF006487; GcvT; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000256|ARBA:ARBA00022576, ECO:0000256|HAMAP-
KW   Rule:MF_00259}; Reference proteome {ECO:0000313|Proteomes:UP000029554};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00259}.
FT   DOMAIN          7..256
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          280..359
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   360 AA;  39495 MW;  5FA92BB75DF5DBF5 CRC64;
     MKNTALSHIH ESLGAKMVPF AGFNMPVSYE GVNAEHETVR NAVGVFDVSH MGEFLLSGEN
     ALALIQKVTS NDASTLEIGK AQYSCLPNND GGIVDDLIVY KIKEEQYLLV VNASNIDKDW
     DWISSFNDLG VEMKNLSEDY SLLAIQGPKA VEAMQSLTSI DLSAIKYYNF EVADFAGIEN
     VIISATGYTG SGGFEIYCKN SEVEQIWNKV FEAGADFGIK PVGLAARDTL RLEMGFCLYG
     NDINDLTSPL EAGLGWITKF TKEFTNSENL KKQKEAGVTK KLVGFELIER GIPRHDYEIV
     DADGNNIGIV TSGTQSPSLG KAIGMGYVKT EFSAVDSEIY ILIRDKKIAT KVVKLPFYKK
//
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