ID A0A095VQ22_9GAMM Unreviewed; 1098 AA.
AC A0A095VQ22;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=HRUBRA_01931 {ECO:0000313|EMBL:KGE03552.1};
OS Pseudohaliea rubra DSM 19751.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Pseudohaliea.
OX NCBI_TaxID=1265313 {ECO:0000313|EMBL:KGE03552.1, ECO:0000313|Proteomes:UP000029640};
RN [1] {ECO:0000313|EMBL:KGE03552.1, ECO:0000313|Proteomes:UP000029640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19751 {ECO:0000313|EMBL:KGE03552.1,
RC ECO:0000313|Proteomes:UP000029640};
RX PubMed=25414506;
RA Spring S., Fiebig A., Riedel T., Goker M., Klenk H.P.;
RT "Genome Sequence of Gammaproteobacterial Pseudohaliea rubra Type Strain DSM
RT 19751, Isolated from Coastal Seawater of the Mediterranean Sea.";
RL Genome Announc. 2:e01208-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGE03552.1}.
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DR EMBL; AUVB01000054; KGE03552.1; -; Genomic_DNA.
DR RefSeq; WP_035513517.1; NZ_KN234745.1.
DR AlphaFoldDB; A0A095VQ22; -.
DR STRING; 1265313.HRUBRA_01931; -.
DR PATRIC; fig|1265313.6.peg.1910; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_009270_0_0_6; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000029640; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000029640}.
FT DOMAIN 2..482
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 494..760
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 903..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1098 AA; 118738 MW; 50C84F1CC4BB3098 CRC64;
MSLADADARL AAIDPTRSVC VSAPAGSGKT ELLIQRFLGL LARVEHPEAV LAITFTRKAA
AEMRERILGA LLEAAAEAPI ASEHGRRTRE LAERALFRDR EAGWGLLENG NRLRVRTIDS
FCAELARQMP LLSTLGGAVS TVDDASELYR EAAEGLLGGL DRDPQQNPAL AALLAHLDNN
WERLANLLAS LLACRDQWYS YLGEHRDGTA SEAFLRRALH ALAADVLGDL SERFRLRAAA
LGPLLGWRHA QGAGGDLEGM PGPSPAALPA WRELAAVLLT GEGEWRKKVT KTQGFPGGAK
VEAVAAMNAW LEEARADRAL AQALARVRIL PSPDDAGAWP ILLSLARVLP RAVAQLLLVF
QRRGAVDHSQ MALAALDALG EDDTPTDLAL RLDYRIEHIL VDEFQDTSHM QFELVRRLTR
GWAEHNAANT GAPRTVLVVG DGMQSIYGFR DANVSLFLKA RDEGFDGLRL VPLQLASNFR
SVAPVVEWVN DHFAAAFPPQ DDVVAGRVRY TPAVPTRQGS GGVAVHCFRG EDGADLAAAE
ADFVAAGVLA ALRQAPEEPC AVLGRTRRQL QPVLSRLRTA GVSVAAQDVD ALASRPVIAD
LLVLCRALAD RYDRLAWFSL LRAPWCGLCL ADLLAVHRAV GAGTVAGWLT GERAAVGLSR
DGGARLAALA AVLGRAEATR DRRGLRGWLE TAWLGLGGPA CYDPDSDSAA AQFFTLVERA
EAEARGLAVP WLEREVSRLY AAPGDPRAPV QVMTLHKAKG LQFDRVWLLD IAASTRGDER
ELLAWDEHVT RAGERFFLLA AEDHSDRRSP SLYQYLREEA AMKRSLEATR LLYVGATRAV
RELVLCVRPR WDEQRESYRE PASAALAAAL WPRLLEGAAE HSVEPGPTPS GPAPLALERL
AIPGGAPEAP SPESPGPQTP REFMGFQERC IGTAVHRVLE ALTGREPLPA CCGEVEQQMA
ALVLAQAGLP AGSRSGALAE VIAHVDRTLA EPQGRWVLAP HPEGATEWSL TALDEAGDPR
QLVLDRYFRD GTTGEHWIID YKTSRPLPEE TAEAFEAREA AAHGGQLARY REALEAILAA
PVRCGLYFTA LGRLLPFP
//
