ID A0A095X0I4_9GAMM Unreviewed; 1804 AA.
AC A0A095X0I4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=HRUBRA_00993 {ECO:0000313|EMBL:KGE04409.1};
OS Pseudohaliea rubra DSM 19751.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Pseudohaliea.
OX NCBI_TaxID=1265313 {ECO:0000313|EMBL:KGE04409.1, ECO:0000313|Proteomes:UP000029640};
RN [1] {ECO:0000313|EMBL:KGE04409.1, ECO:0000313|Proteomes:UP000029640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19751 {ECO:0000313|EMBL:KGE04409.1,
RC ECO:0000313|Proteomes:UP000029640};
RX PubMed=25414506;
RA Spring S., Fiebig A., Riedel T., Goker M., Klenk H.P.;
RT "Genome Sequence of Gammaproteobacterial Pseudohaliea rubra Type Strain DSM
RT 19751, Isolated from Coastal Seawater of the Mediterranean Sea.";
RL Genome Announc. 2:e01208-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGE04409.1}.
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DR EMBL; AUVB01000027; KGE04409.1; -; Genomic_DNA.
DR RefSeq; WP_052094836.1; NZ_KN234785.1.
DR STRING; 1265313.HRUBRA_00993; -.
DR eggNOG; COG0642; Bacteria.
DR eggNOG; COG0834; Bacteria.
DR eggNOG; COG4251; Bacteria.
DR HOGENOM; CLU_238021_0_0_6; -.
DR Proteomes; UP000029640; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 3.
DR CDD; cd01007; PBP2_BvgS_HisK_like; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 2.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.120.160; HPT domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR NCBIfam; TIGR00229; sensory_box; 3.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF01627; Hpt; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF00072; Response_reg; 2.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 2.
DR SMART; SM00062; PBPb; 1.
DR SMART; SM00448; REC; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 2.
DR SUPFAM; SSF47226; Histidine-containing phosphotransfer domain, HPT domain; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50894; HPT; 1.
DR PROSITE; PS50113; PAC; 3.
DR PROSITE; PS50112; PAS; 3.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 2.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000029640};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 672..718
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 743..797
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 798..843
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 874..926
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 956..1011
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1016..1069
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1087..1309
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1326..1445
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 1469..1585
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 1623..1724
FT /note="HPt"
FT /evidence="ECO:0000259|PROSITE:PS50894"
FT COILED 910..937
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1377
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 1518
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 1662
FT /note="Phosphohistidine"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00110"
SQ SEQUENCE 1804 AA; 196198 MW; 1C2354135E7599D6 CRC64;
MPRLARWHYL AVTGLLAGLL IASFLFQGAP QAQGDRSGPV RLELTEAERQ WLREHPVLRA
SGETDWPPFN FRYADRQHGY SVDYLELLAK RLGVEVEYVT GRSWSQFMED LREGRVDVLL
NAVRTEDRAR WMAFTNPYGD FTVGIASRGQ DPIRTSAALA GRTVAHAAGF ASEQFLADYI
PEADAVPAAD IRAALDLVAA GKADAAIGVT PSMRYQIAEH LLDNVAVTGI IPVPGDDWRL
LRLAVHKDQQ QLVTILEKAV ATVSERELRS LRAHWLDDAQ FRGAIAAGED EPSLGFLAPS
LVALVLVLLI ALLWLFFNRL SAPMQERLVS DARLRAWLVA LLLAFFLVTT WLAWHAMERR
ELATRKLYGE TLLGINALLL EDLRQWSARW RDVARQLAAD PRVRATVMEG EPAAMEKSCR
LLGAVCAFAG RDDLRVVLAG GETVAQLSVP EAVWQGDTRF EVLPPRPGEP RRFAVFAPVR
DGPDEAISGA VILTKSLVEA GLLRVFEAAR VGGTGESYAM DGTGRLVSAT RFPGMVQGFA
KLLEDGVLQA RDPGGSLQDG YEPTGKPSQW PLTRLAQSAL AGDTGVDIDG YRDYRGVTVF
GAWAWFEPLG IAIATEIDAA EVLDPLRLEQ KRLIGLLSAI LLVVLALLAF LFWLGGTARL
SLRRRLQQQE RELRTLGAAL RASPLAVLST DREGTILSTN PAFTTITGYT PEEALGQTPR
ILKSPRTPTR THDELWDSLL AGNTWRGELV NRCKDGSEYN ARMTITPLLD NRGQPETFVG
VQEDITETVS AHNAEARASR RVELLLANAG EGIVGLDRQG HIVFTNHALR TMLGYDAGEL
EGEYMHGKLH YARVDGSPMP ESECHMMPGL EARQVVEEDV LWRRDGTPLS IAYTASPVQD
DPDGLAVVVV VRDITARKRA ERQLQSAEQR LVGAAEAAGL GLWEYRPGQG VRDVSVNEQL
PRLLGYAPEQ LRAGSGPWAP LREGHKTMEE LLNPEDVPSV GEHLMNMLRA RGEYTSRVEF
RMRCADGRWR WFAAVGQVLE RDAEGRALRV AGVQIDIERD KELAHRLEEA KLAAEAASRA
KADFLANMSH EIRTPMNAII GMTQLALNTE LNERQRGYVG KSYEAAQSLL TIINDILDFS
RIEAGRLEME SSEFDLDEVF GGLGSLVGLS AEEKGQELVF YRAPNVPRWL VGDAGRLRQV
LVNLGSNAVK FTGDGGEVVV MVQLAAASDD IAELHFSVRD TGIGMSEEQQ QKLFQAFTQA
DTTITRRYGG TGLGLAISKN LVGLMGGRIW CESEPGIGST FHFTAQFIIA GEDGAALPGA
EVDSPRVLLV EDSATTRMLV ASMLSNLDCE VDSVDSGEAA LIRLAAADRP YDVVVMDWKM
PGMDGIATVR AMLDDDRFAD VPAVVMATAY AANDARSAAG DLPIEIFLQK PVTPSSLFDA
IVTSLGAHVV SAGGARPRNP GSSGITGARI LLVEDNDINR EVAQEFLAGE GVEVLTAVNG
EEALAVLEQE AVDGVLMDCQ MPIMDGYEAT RKLREQPAFA ELPVIAMTAE VMTGDRERAF
AAGMNEHVGK PIDFDELSAV LRRWIVPASG RAAPRRPVPS MVPELPLLPG IDRDAALANA
GGSGELVLRL LDRFRKDYRD YEGSFREALR VEDGAAAERS AHTLKSVAGT LGAGDLETAA
GDLERTLKEN GDQGSVDEAL ASTLAALAVV LESLEALHEA GPAERDASDQ AAPDSEALAN
GLAELDRLLA DNDTGALELF AHLRDALEAR YGERPIRRLA VAVDGYEFGQ ARTRLAALEP
GDAA
//
