ID   A0A095XYR7_9CORY        Unreviewed;       911 AA.
AC   A0A095XYR7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Aminopeptidase N {ECO:0000313|EMBL:KGF15173.1};
GN   ORFNames=HMPREF1650_11910 {ECO:0000313|EMBL:KGF15173.1};
OS   Corynebacterium freneyi DNF00450.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=1287475 {ECO:0000313|EMBL:KGF15173.1, ECO:0000313|Proteomes:UP000029548};
RN   [1] {ECO:0000313|EMBL:KGF15173.1, ECO:0000313|Proteomes:UP000029548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DNF00450 {ECO:0000313|EMBL:KGF15173.1,
RC   ECO:0000313|Proteomes:UP000029548};
RA   McCorrison J., Sanka R., Torralba M., Gillis M., Haft D.H., Methe B.,
RA   Sutton G., Nelson K.E.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M1 family.
CC       {ECO:0000256|ARBA:ARBA00010136}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGF15173.1}.
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DR   EMBL; JRNE01000081; KGF15173.1; -; Genomic_DNA.
DR   RefSeq; WP_035123596.1; NZ_JRNE01000081.1.
DR   AlphaFoldDB; A0A095XYR7; -.
DR   MEROPS; M01.009; -.
DR   eggNOG; COG0308; Bacteria.
DR   Proteomes; UP000029548; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd09602; M1_APN; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR045357; Aminopeptidase_N-like_N.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR024571; ERAP1-like_C_dom.
DR   InterPro; IPR012778; Pept_M1_aminopeptidase.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   NCBIfam; TIGR02412; pepN_strep_liv; 1.
DR   PANTHER; PTHR11533:SF304; AMINOPEPTIDASE N; 1.
DR   PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR   Pfam; PF11838; ERAP1_C; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   Pfam; PF17900; Peptidase_M1_N; 1.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:KGF15173.1};
KW   Hydrolase {ECO:0000313|EMBL:KGF15173.1};
KW   Protease {ECO:0000313|EMBL:KGF15173.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029548}.
FT   DOMAIN          23..214
FT                   /note="Aminopeptidase N-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17900"
FT   DOMAIN          273..484
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
FT   DOMAIN          582..897
FT                   /note="ERAP1-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11838"
SQ   SEQUENCE   911 AA;  98770 MW;  CB72B95E52493ABB CRC64;
     MTSTNLTQTE AADRAAMLEV SLYDISLDVT GAPGTTAAPG DDTFRSTTTV TLTAKRDGTT
     FLDLRNADIR SVTIDGTDVT DAACGGSKKL YDDERGLILD LTAGDHVVVV DADCRYTTTG
     EGLHRFTDPA DEQTYLYSQF ETADAKRVFA CFDQPDLKAT YTMDVTAPGD WTIVSNSEPE
     VADIAPADGD IAPLDGPAAR IHRFRVDVPL STYLIAFCAG PWHEVRDQWT GTVAKHPETP
     ADHQPDGELT IPLGLYCRAS IAEHLDAERL FRETKEGFDW YAANFGEPYP FGKYDQIFCP
     EYNMGAMENA GAVTIRDEYV FRSRTTGYLY ERRNETILHE MAHMWFGDLV TMQWWDDLWL
     NESFATWSAC ASQAAVSEYD GAWTTFANVE KAWAYQQDQL PSTHPIAADA SDIDTVDQNF
     DGITYAKGAS VLKQLVAYVG EDAFLAGARL HFARHRFGNA TFDDLLGALS EASGRDLSGW
     ADQWLTTTGI NTLSAAYSTK KAEGGAAGDA AAGGAAEVYD IFAIRQTGAE PGAGELRDHR
     VAVGVYAMDG GLLRRTHRVE VDVKGETTEV PEMSGVPVGD VVLVNDDDLS YCFMEMDPGS
     WLFLLENIGA FADPMPRTLA WSTMWEMTRA AKVRARDFVA MVLRGAPSED QISVLERVLS
     QAVAAVERYA APDWVAEGRR LLGEGLLDHA RAAEAGSDAQ LAFVNALAML PADGAGSLEV
     FRAILAGEPE SVGLDGLTVD EDMKWNALTV LVAAGDKGVS DIAAAEQADQ SALGTQSAAK
     ARAAIPAADN KIRVWNTCTA TGAAAPSNLM LRSMIAGFTA PGSDGLLGDF TDRYFAEAPS
     WWGRYSSETA QRMLDGLYPH WDVSREGLDK AAALLDDEST PAPVKRIVAE NRHRVERALA
     ARECDGFVPE Q
//