ID A0A095ZJV9_9BACT Unreviewed; 1235 AA.
AC A0A095ZJV9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=HMPREF2137_05525 {ECO:0000313|EMBL:KGF34983.1};
OS Hoylesella buccalis DNF00853.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Hoylesella.
OX NCBI_TaxID=1401074 {ECO:0000313|EMBL:KGF34983.1, ECO:0000313|Proteomes:UP000029556};
RN [1] {ECO:0000313|EMBL:KGF34983.1, ECO:0000313|Proteomes:UP000029556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DNF00853 {ECO:0000313|EMBL:KGF34983.1,
RC ECO:0000313|Proteomes:UP000029556};
RA McCorrison J., Sanka R., Torralba M., Gillis M., Haft D.H., Methe B.,
RA Sutton G., Nelson K.E.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGF34983.1}.
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DR EMBL; JRNN01000061; KGF34983.1; -; Genomic_DNA.
DR RefSeq; WP_036872450.1; NZ_JRNN01000061.1.
DR AlphaFoldDB; A0A095ZJV9; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000029556; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..82
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1235 AA; 140791 MW; C210EAC0838D95BD CRC64;
MNDFVHLHVH TYYSILDGQS PVKRLVDKAV TDGMRGLAIT DHGNMFGIKE FFDYANTVNK
QLKADGKQPF KPIFGCEMYV ARRSRFDKVK DMGDMSGYHL IVLAKNYRGY KNLIKLVSHA
WEEGYYMRPR TDREELEKYH EDLIVCSACL AGEVPRKIIA GDMAGAREAV EWYKRVFGDD
YYLEIQRHEV KDPSIRANRE AYPMQQRANQ LIFNLAKEYG IKVVCTNDVH FVDKENAEAH
DHLLCLSTGK DLDDPTRMLY SKQEWFKTRE EMNSIFSDVP ETMANTIEIL NKVETYSINH
DPIMPNFPIP ESFGKEEDWK QKFTEEDLLR EFTTDENGEN PMSEEDAQKR VDHLGGYEKM
YRIKFEADYL QHLAYEGAKP LYGDPLPKEV DDRIRFELHV MKTMGFPGYF LIVSDFIRAA
REELGVMVGP GRGSAAGSVV AYCLGITKID PLKYDLLFER FLNPDRISLP DIDTDFDDDG
RGKVLKWVMD KYGHENCAHI ITYGSMATKN SIKDVARVEK LPLERANALC KAIPDRLPDK
MKMNLTNAIK CTPELQMAEA STDIRESNTI KYAKMLEGTV RGTGIHACGF IICRDPISDW
VPVSTADDPD FKDEKTNCTQ YDGHVIEETG LIKMDFLGLK TLSELKEAVK NVKLTKNIDI
DLDKIPIDDE LTYKLYQEGR TIGTFQFESA GMQNYLRQLS PTKFEDLIAM NALYRPGPMD
NIPSFIARKK GEEEITYPIP VMERYLKDTY GITVYQEQVM LLSRLLANFT RGESDALRKA
MGKKKKAIVD AMKPKFIEGG KKNGYDENVL DKIWADWEKF ASYAFNKSHA ACYSWVAFQT
AYLKAHYPAE FMAAIMSRRK DQITEISKLM DECKSLRIAT LGPDVNESYQ KFGVNHKGEI
RFGLAAIKGM GDAAATAIIQ EREAHGLYQD IFDFAHRVDF TQVNRKAFES LALSGGFDSF
GIPRESYFTA NNKGELFIDT LVRYGQLYQN KKSEIEHSLF GGVDAVEIAT PPIPKPELWS
NIEKLNREHD LVGIYLSAHP LDEFSIVLKS MCNTSCTELG DKAELAKKAD VVFAGMITDV
KDKFTRTGKP CGFVTIEDFS GTGEIAFFGE EWGKWKGMMV VGSTVYLTGK CSQRYRDSNY
YDFRINDVQY LQTVRDKQIH RLTIVVDSEA IDEVVVNDIV SMLQDSKGNT QLCFQVADKQ
HQTSILLHSG LHQISLGHDL IRYIEGNPNM NYLVN
//
