ID   A0A096LRY5_POEFO        Unreviewed;       892 AA.
AC   A0A096LRY5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=SET domain bifurcated histone lysine methyltransferase 1b {ECO:0000313|Ensembl:ENSPFOP00000021926.1};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000021926.1, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000021926.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AYCK01003730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A096LRY5; -.
DR   Ensembl; ENSPFOT00000021830.1; ENSPFOP00000021926.1; ENSPFOG00000004429.2.
DR   GeneTree; ENSGT00940000157471; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01395; HMT_MBD; 1.
DR   CDD; cd10517; SET_SETDB1; 1.
DR   CDD; cd20382; Tudor_SETDB1_rpt1; 1.
DR   CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR   Gene3D; 2.30.30.140; -; 3.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR040880; DUF5604.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR047232; SETDB1/2-like_MBD.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR041292; Tudor_4.
DR   InterPro; IPR041291; TUDOR_5.
DR   PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   PANTHER; PTHR46024:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1; 1.
DR   Pfam; PF18300; DUF5604; 1.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF18358; Tudor_4; 1.
DR   Pfam; PF18359; Tudor_5; 1.
DR   SMART; SM00391; MBD; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00333; TUDOR; 2.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          734..807
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   REGION          88..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..69
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        477..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  98801 MW;  B7305B0BBC194E45 CRC64;
     MEVDGWDPSL EDELGVSLDD LKKWIEEAVE QSEAVKKKKA QLIELEEWVE QKEKEEAKTE
     KLLNDANQSV LECEKLVRAA YENNGLVYRE SSSDDEGGGG GGLPSEVIEI DDDDDDDVIA
     VGCSSVVPPK TQAPSKDPTL NEASAVLQKT TQQVQKLVQI VTKPSSASPL IRTAVQSVVQ
     PDPAGVQSTT PAIFVSQAPS HQTMTQTQPN PNIKEDELKV GMNILGKKRT KTWHKGNLVA
     INPVGNGVFK YKVRFDKGKS LLSGNHVAFD YNPTLESLYV GARVVAKYKD GNLVWLYAGI
     VAEMPNNKNR MRFLIFFDDG YASYVILPEL YPVCRPLKRT WEDIEDASCR DFIEEYISAY
     PSRPMVLLKV GQIIKTEWEG TWWKSKVEEV DSSLVKILFL DDKRSEWIYR GSTRLEPMFN
     LKLASANTQE KKLAGHQRTR PNMGALRSKG PVVQYTGAAS AAAAAPAPPA GPAVPANPAA
     TSSTNPANPS ALTGCPVSTS RNKHQMAKKS TSNFIPGVGG THASKILQAA SANASNLSVM
     QKQCLRQTTA LAPPPSIVTH AMATIPQQPS YRAPTDRIFY LAHTCQPACL NRVRPAKSDL
     HRGKNPLLTP LLYDFRRMTG RRKVNRKMSF HVIYKAPCGL CLRNMGEIQN YLFQTRCDFI
     FLEMFCLDPY VLVDRPFQPQ RPFYYIPDIT SGKEDIPLSC VNEIDTTPPP NVKYSKERIP
     EDGVFINTSS DFLVGCECTD GCKDKSKCSC HQLTLQASGC TPGGQINQSA GYSYKRLEEC
     LPTGIYECNK RCKCCAQMCT NRLVQHGLQV RLQLFKTQNK GWGIRCLDDI AKGSFVCIYA
     GKILTDDFAD KEGLEMGDEY FANLDHIESV ENFKEGYESE AHCSDSEGSG VD
//