ID   A0A096LS36_POEFO        Unreviewed;       612 AA.
AC   A0A096LS36;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Arylsulfatase H {ECO:0000313|Ensembl:ENSPFOP00000021977.1};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000021977.1, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000021977.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   EMBL; AYCK01019501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A096LS36; -.
DR   Ensembl; ENSPFOT00000022239.1; ENSPFOP00000021977.1; ENSPFOG00000008836.2.
DR   GeneTree; ENSGT00940000161140; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1120.10; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   Gene3D; 1.10.287.550; Helix hairpin bin; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR42693:SF16; ARYLSULFATASE H; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   Pfam; PF14707; Sulfatase_C; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        215..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          54..438
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   612 AA;  68502 MW;  3F27D1FA5C37166B CRC64;
     MSVKLTRRKF FWEKEIGVIY DCLLLRSAML APLLLSLLLA SGSDVKGEVE DKRPNFVLMM
     VDDLGIGDIG CYGNDTISSR RTPNIDRLAS EGVKLTQYIA AAPLCTPSRA ALMTGRYPLR
     SGMASPGRVQ VLLFLGGSGG LPPNETTFAK RLQQQGYTTG LVGKWHQGVN CESRGDHCHH
     PNQHGFSYFY GLPFTLFNDC VPGEGSDVLV DLQLALQHLT LLLGLGLLTM VCVRLCGLLE
     VSLWLLVLLF FVSTVAAAVW YVPFGLLRTW NCIIMRNQDV IEQPMTVETL PQRLLAEAQN
     FIKRNADRPF LLFFSLAHVH TPLFTTPAFA GKSLHGRYGD NLEEVDWIIG KIMETVDSLG
     LANNTFMHFT SDHGGHLEDS DSLIGQKGGW NSIYKGGKAM GGWEGGIRVP GIFRWPGRLA
     AGRVVDEPTS LMDLYPTLKY LAKDTHPDRQ LDGYNLMPLL EGKAARSEHE FMFHYCGVYL
     NAVRWHPPDS NSIFKVHFFT PNFFPPGAGG CYDTRVCLCH GQHVTHHNPP LLYDLFHDPS
     ESRQLTPETE PRYAEILQQI AKAVEKHKST FPTIQNQMSW EKILWRPWLQ PCCGTFPFCG
     CKLSSFDKIL SH
//