ID A0A096LT34_POEFO Unreviewed; 2819 AA.
AC A0A096LT34;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=von Willebrand factor {ECO:0000313|Ensembl:ENSPFOP00000022325.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000022325.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000022325.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01001942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000027243.1; ENSPFOP00000022325.1; ENSPFOG00000019119.2.
DR GeneTree; ENSGT00940000155810; -.
DR OMA; KFEACHH; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 5.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF361; VON WILLEBRAND FACTOR; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 4.
DR Pfam; PF00092; VWA; 3.
DR Pfam; PF00094; VWD; 4.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00327; VWA; 3.
DR SMART; SM00214; VWC; 4.
DR SMART; SM00215; VWC_out; 3.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF57567; Serine protease inhibitors; 5.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50234; VWFA; 3.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 3.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..2819
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001919290"
FT DOMAIN 29..197
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 384..558
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 862..1029
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1276..1449
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1487..1657
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1680..1858
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1935..2117
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2261..2333
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2434..2500
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2587..2652
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2731..2819
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1455..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2731..2781
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2746..2795
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2757..2811
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2761..2813
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 2819 AA; 308261 MW; 97EA8319468CB393 CRC64;
ISLVRVFSTI VVWVGAGTDT LSCVASITGR CSLFGRHHIH TFDGVIYEFP GDCSYLLAGD
CNHHSFTLLG DFQNGKRTGI TLFLGDVFEL HLSADGQLSQ GFHRLSLPYA SHAVFVGSEL
GFYKLWSEEF GFAVTIDNAA NIAVTMTKLH SNRTCGLCGN FNAIPSDEYT AQEGFLTEDS
YDFANSWAVK GADQACRRVS DPTQSCNSTK GTAAEEVLSS CSVLQTSSLF LHCSHLVSPD
AFLSLCQAEA CYCDQKNPED CSCPFLLEYV RTCRSHGVLL HGWVEESQCF PKCPIGMQYS
ECTKPCSTTC HSLNIQEVCK EECVDGCTCP TGKVLDGNRC VEVSQCSCTH MGRHFPPGST
ISQDCNTCVC RHGSWECTNE GCPGECLVVG QSHFKSFDNK FFTFVGHCQY LLAKDCTNNG
FSVIIENVQC ADDQDAVCTR SVTLSLPSLE NMTVKLKHGG VVSVNSMDIQ TPMNHGHLHI
ARSAQSSVRV KFGDDLRLDW DGRGRVLLKL GPRWTGQTCG LCGNYNGNHG DDFLSGSGLV
EASPQAFGQA WRINGDCEST HKYGTDPCAT NPKRVRYAEE ACAVIMSDVF SSCHFLVNPA
PFQRFCRYDV CACGDGEQCL CSALSAYAAA CSAKGVLLNW RSPSLCEMEC PGGQVYEACG
STCERTCRSL SGAEPGCEGE RVCEEGCFCP AGKYLSPSGE CVTADMCPCL HDGQLYQPSD
VYADHNSICY CENGAMRCSS TEMTSFLSDL FYDDDTVPSR ERRSVQCPPP LVHAECSSGE
RGLECARTCQ NLDLPCVSLA CIPGCLCPPG TVRHRRDCIQ PEQCPCYHNN RPYTAGRSIT
VDCNTCVCEN RKWRCTQKLC DGVCRTVGEG HYITFDGLKY SFPGLCQYVL VQDMCHADEG
SFRVLVENEA CGIVGDRCAK AVTIFYHGGL IAMQDGEVTM KRPVLQSSQV EIVRSGQFYT
VMLGKHISLS WDRGTRLLVH ISASYRGRVC GLCGNFDGNV NNDLMSSNNQ LEMDASHFGN
SWKVIPSCAD VTESMNTNIQ MPAPCSDNIV KLVTVEQSCR VITGPLFKEC NSQVDAEAYV
EMCVEAACSC SSVGDCACFC DAIAAYAQAC SEKGVSVMWR SNELCPMSCE ELNPKLAGTR
EELCQWRYNT CGPACPITCQ HPDPLHCSLT CVEGCHAYCP PGQILDEVAM QCVDPSQCQV
CIHEGQRISH GNKVILNHDD PTHCKKSHCE NNTLSCEDCT SLNMLSTPTP TPSYGTFTTM
PFTTLMPEGM CDRAMDLAFL LDGSEALTED EFQATKEFIL GVVERFRMGS AHTRATVLLY
HSGVKTYDLQ VQKWLFKKTV RELHYTGGDA AFLDEAVKYL AINIYDKNKR DNAGRVAIIL
TASGNPRPVR AIVKMLRKKA ITTLTVALGP GVNMGQVNDI TKANPDNRAY VLSSTGELSD
RLLEVTDYLC TLGMEPEMPK PTPNKARQAS PTTSPTTIPP YHPPATDVTF IIEGSDTVGE
ANFNKSLVFL EEVISQLTEK EEFIRITVIQ YSVTVTVEIS RWELRQQREH LLQRLRQIRW
RGGSKTNTGA AVTMTLQEMA TVHPPHVPAP PQLVFLVTEN PPTDTVTRPP TTSVQTRLYP
IGVGPKVHET DLVQFSHPQR PMMVEDYSRL TSLVHRVYWS ISHINITMYH HTVPCKKPLD
VMFLLKAGEQ FEDMKTFVKT FISNADIGAG PGGTQVSLIQ YGDINTAEFM WNSHQSKSDL
LKRVEGIPTR TAAAPALGSA VKFAVQTSIS SVSGGRVGVP KVVVMVMTEK SSDDIKEAAN
EALAAGVSVF PIGVGPNYDS NELSALGHHG NQDNTLHLNN MDQLRIFLTL DKSYMERICR
GPPGVCVDDN GNERKPGESW LLDDGCHSLL CHPSGAVTVQ NHKISCDRLE PPACRNNMPP
VRVEEACGCR WECPCICMGS STNHVVRFDG LALRLEGEGL CSYTLLTVSK GDSEGSEVKL
HTGPCQDSAK YSQICMKSME VTHGPYTLLL KDDITAIIGR EELALPWRHS GLEVVRYGGV
MLQLKSDQGY VLTFTPQSNE FTITLLSSET SGHTAGLCGA CGEAKVNVLS FRNGSTTTDQ
PAFISDWTVA ADGGVCLPKR KAVCVSGVAM GCQALRSEVF EKCHAYIAVQ VFLIKCEEQA
CDESDVCELI SAYARLCRQS GVCVDWRSPH LCPLHCPNSM EYDACRTGCV KDCGSLQVLP
GDWSTTRRNE SSCMETPTEG CFCTGGTVLH HGKCVSPESC RQCVDHQGHT YAHMQSWVPD
DNPCLICMCL DQQHINCTAR PCNDVKAPVC GPCEILQEKK ESKCCPEYEC VCDLVSCDLP
DVPRCEDGQT VVLKNPGECQ PIHECVCKKE ECSQQDPPDC PAHRQLSTKK TKCCDSFECT
CNCQNSTQSC PTGFVTSSFT NDCGCTEILC QPDKVCVVGG VVHPVGSEWE EGCEKCRCTE
LQDRDTSLHV AQCSPPVCNR NCPVGSTYTQ RKGSCCGECT PASCTETEGA MRGDTVIGGK
LRRVGEKWLS AHDKCVEHEC KKVKDEVFIS TTNVSCGSME TTSCPLGSEL RCDTQDCCPR
CHCAPMDVCV LNHTVIGAGE RVMVDLCTHC ECTVENGAVK KYKLSCKRTS CPSCPRGYAM
QKEGDSCCGR CVPTACFIQK PDGKLTSVQV NSTQEDGCYL YACGVNSRGD LVLETKQTTC
PPFNRQACLD GGGKVSQIGK TCCETCNEPE CRRTAGTLNY VKVDDCQSEQ QIELHYCEGK
CRSKSMYSLQ SAAVEQECVC CAAMKTEPLS VPVLCANGTR SHHTVQSVTT CDCVSKHCN
//
