ID A0A096LTM9_POEFO Unreviewed; 1084 AA.
AC A0A096LTM9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Integrin subunit alpha 6 {ECO:0000313|Ensembl:ENSPFOP00000022520.1};
GN Name=ITGA6 {ECO:0000313|Ensembl:ENSPFOP00000022520.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000022520.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000022520.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AYCK01002192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LTM9; -.
DR Ensembl; ENSPFOT00000031687.1; ENSPFOP00000022520.1; ENSPFOG00000012352.2.
DR GeneTree; ENSGT00940000155353; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 31..1084
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001422849"
FT TRANSMEM 1005..1029
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 105..165
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 300..361
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 362..419
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 422..482
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 467..624
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 626..781
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 791..994
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1084 AA; 119855 MW; E94322877959C7CF CRC64;
MALLQQRGRF AVRAALFLLC HLLEPSGLRA FNLDTRHVIR KGGEPGSLFG LSLALHQQVS
PNKVLLLIGA PRAKALKNQK SSVTGGLFKC EISESDNCER VEFDNDEDPS QEIKEDQWMG
VSVQSQGPGG KVVTCAHRYQ KIRSGSQSVL GRCYVFSQNL TINLSDDMDG GDWKFCEGRD
GETDHARYGV CQQGLGVTFT KDYHYVVFGA PGARNWKGMV RVEQDNITLV EKNIFHDGPY
EFQDDKHPSS VSAHSYLGFS LDTGHHIMKS RNLTVVAGAP RANHKGLVVL LKKESAEQLV
VEQLLHGQGL ASSFGYDVAV VDLNGDGWQD IVVGAPYFYM KDTDIGGAVY VYINKAGQWD
NVTLIRLNGT KDSMFGLAVE NIGDVNQDSF NDIAVGAPQD DEGAGRVYIY HGSAQGIKTT
PAQILSGKEH SLRYFGYSLA GNMDLDGNSY PDLVVGSLSD AAFIYRARPV VNIRKNVTVS
PEEIDLGVGC DSSFCFTVTA CFNYTARSYN KRLTISYSIE ADGERRKQGL NSRVIFLTKT
HPESDIQFNG TLELQNQNAG QCVSINVGLK DNIKDKMRSV VIEVSAEIIK AKPQRAGNAL
SQLMPVVDAT QPRQAVAEVN FVKEGCKNKK ICFSNLKMDN SLHYKPTSKD EFTPLNKSAL
NIPEFRLTYE TKALAVKVTV TNENGDDAFE AKLVGKFPEI LSYSGVRSVL CVPNNQILCT
ANHNGSEAEC ELGNPFKSNS KVMFHIILSA AHNAVKLDTT EFEIDLHLQT TSSQNISAVK
IKSKVITEVP LILSGEAKPR QVSFGGVVRA ETAMKTEEDA GSLINFTFRI SNLWTPSISP
LPLTLHIHWP RDNKNGKWLL YLVKVTSHGP EKIACSPQSE IHSLKNIWER SPSLTKQEIV
KKERKLGGKI VFHSSSNKVL SCEKESKCVV LKCPLQGING TTVELRSRLW NSTFIEEYAS
FPTTTLVVKA SLVLESQTPN IILKSPDFTV TVPVSPDSDV AQFGVPWWII LIAVLAGILI
LALMVFLLWK CGFFRRSKQD DSIPRYHAVR IKKETPGYVD GKMKPGALEK KQWMTTWIDD
DDYS
//
