ID A0A096LZ30_POEFO Unreviewed; 392 AA.
AC A0A096LZ30;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=GPI-anchor transamidase {ECO:0000256|ARBA:ARBA00019393};
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class K protein {ECO:0000256|ARBA:ARBA00029842};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000024421.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000024421.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBUNIT: Forms a complex with PIGT, PIGS, PIGU and GAA1.
CC {ECO:0000256|ARBA:ARBA00011178}.
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; AYCK01011907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01011908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01011909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LZ30; -.
DR Ensembl; ENSPFOT00000022304.1; ENSPFOP00000024421.1; ENSPFOG00000001237.2.
DR GeneTree; ENSGT00940000156273; -.
DR OMA; PGHTNNW; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:InterPro.
DR GO; GO:0003923; F:GPI-anchor transamidase activity; IEA:InterPro.
DR GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR028361; GPI_transamidase.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR48067; GPI-ANCHOR TRANSAMIDASE; 1.
DR PANTHER; PTHR48067:SF1; GPI-ANCHOR TRANSAMIDASE; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500138; GPI8; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 164
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 206
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ SEQUENCE 392 AA; 44883 MW; 7E0D908C002CAE46 CRC64;
LRVLYAKERT PRLLVAFALI NFSGIVSTFY QNTAGQFFSS GHTNNWAVLV CTSRFWFNYR
HVANSLSVYR SVKRLGIPDS HIVLMLADDM ACNHRNPKPA TVFSHKNMEL NVYGDDVEVD
YRGYEVTVEN FLRVLTGRLP SSTPRSKRLL SDDRSNILIY LTGHGGNGFL KFQDSEEISN
VELADAFEQM WQKRRYNELL FIIDTCQGAS MYERFYSPNI MALASSQVGE DSLSHQPDLA
IGVHLMDRYT FYLLEFLEDI HPASKANMND LFKVCPKSQC VSTPGHRTDL FQRDPGSVLI
TDFFGSVRKV EITTEVVNLT DPIEQVDESP ANGEAREEMY SYVDQLPVSE IIHQKPKQKD
WHPPDGFILG LWTLILLVFF KTYGVKHLKH IF
//
