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Database: UniProt
Entry: A0A096M0N2_POEFO
LinkDB: A0A096M0N2_POEFO
Original site: A0A096M0N2_POEFO 
ID   A0A096M0N2_POEFO        Unreviewed;      4949 AA.
AC   A0A096M0N2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   16-JAN-2019, entry version 29.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPFOP00000024973};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSPFOP00000024973};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000024973, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000024973, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000024973};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000024973}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AYCK01000221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000027585; ENSPFOP00000024973; ENSPFOG00000016822.
DR   GeneTree; ENSGT00940000155507; -.
DR   OMA; MVTCTLK; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4273   4300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4491   4511       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4558   4577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4700   4726       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4749   4771       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4830   4853       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    217       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    280       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      286    349       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      351    408       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    808       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1024   1220       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1334   1548       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4023   4049       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2913   2933       {ECO:0000256|SAM:Coils}.
FT   COILED     3485   3505       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4949 AA;  560363 MW;  E437E1E94B4D04B9 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQSVATILK EHRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DMCICNFVLE QSLSVRALQE MLANTGTSSE GKADHEKWRL IKKAGQGGGH RTLLYGHAIL
     LRHSFSDMYL TCLKTSRSLT DKLSFDVGLQ EDSVGEACWW TIHPASKQRS EGEKVRIGDD
     LILVSVSTER YLHLSNCNGN IQVDASFMQT LWNVQPTCSS GSMAVEGYLI GGHVMRLCHG
     HDESLTIPGA DKSEEEQRIV NYEAGKGASR ARSLWRLEPL RISWSGSHIR WGQSFRLRHL
     STGRYLALTE DRGLVLEDRE KCHTKATAFC FKPSKEKGDS GMKRDIDGMG VPEIKYGDSV
     CFVMHVATGL WLSYLAPDAK SSRLGPLKRR ACLHSEGHMD DGLILQRCQH EESRAARIIR
     NTTFLFKNFI KALDSAAAGE TNAVAGYVEE VLQTLNDLIE YFKQPDVDLE HEEKQARLRS
     LIKQQDLFKE EGMLALLSKC IDRMNLYDSA AHFGEMAGEE AGAAWKDILN LLYELLAALI
     RGNRTNCTQF SRNLDWLVSK LERMESSSGI LEVLHCILVE SPEALNIIQK GHIKSIISLL
     YKHGRNHKIL DVLCSLCVCN GVAVRTNQNL ICDNLLPKRD LLLQTRLVND VQSMRPNIFL
     GIAEGSAQYK KWYYELVIDQ VDHFVTGEPT HLRVGWANTK GYAPYPGGGE GWGGNGVGDD
     LYSYSFDGLH LWSGRIPRAV ASINQHLLNS DDVVSCCLDL GAPSMSFRIN GQPVQGMFED
     FNTDGFFFPV VSFSAGVKAR FLLGGRHGDF KFLPPAGYSP CYEALLPKEK MHVEPVKEYK
     RDHDGVRDLL GTTQFLSQAS FIPTPVDTSQ IVLPPHLENI RDKLAENIHE LWGMNKIELG
     WTYGKVRDDN KRQHPCLVDF SKLPETEKNY NVQMSSETLK TLLALGCHVA QVNVHAEEDL
     KKIKLPKDYM MSNGYKPAPL ELSDVKLTPG QEVLVDKLAE NAHNVWAKDR IKQGWTYGIQ
     QDVKSRRNPR LVPYALLDER TKKSNRDSLR EAIRTMVGYG YDIDPPDQTK VVHAIDNQSI
     ETIRFFRVEQ TYAVKTGKWY FEFEVLSGGD MRVGWARPGC RPDVELGTDD QAYVFDGYRG
     RRMHAGSRYF GHPWKKGDVV GCMINMEDKS MIFTLNGELL ITSKGSELGF ADFETEDGFI
     PVCSLGMSQI GHMNLGKDAS TFKYYTMCGL QEGFEPFAVN MNREITMWFS KRLPTFFNVP
     QDHMHIEVTR IDGTVDSPPC LKVTHKTFGT QNSNSDMVYC RLSMPVEFYS ADRLLDESLK
     LRLRFHPHYS LFFSFNKTIN VSNVVWKRMD GVELKCFPGM DESFVYSSIH LFPFSQLLSE
     TFYLNMFVFF SQPPKEDGSI DYLFLFLNLQ YYHSVRVFAG QDPASVWVGW VTPDYHYYSK
     NFSLSKTQTV TVTLGDERGR VHESIQRSNC YMVCAADALG PSSSSRSNTD LEIGCLVDLA
     TGLVSFTANG KELPTAYQVE PNTKLFPAVF CCPTSSNLFQ FEFVKIKDAM PLSSAMFRSE
     QRNPVPQCPP RLDVQTIVAV LWSRMPNTFL NVETARVSER HGWVVQCLEP LQMMAVHIPE
     ENRCLDIMEL SEHEDLRKFH SHTLKLYCAL CALGNTRVAH ALCSHLDQSQ LLYTIDNQYL
     SGMLREGFYD VLISIHLETA KEARLMMNNE FIIPVTDETR SIKLFPDESK RHSLPGVGLS
     TSLKPRVNFS PVGIISTKRH QLLYSPQIPL GILKEKAISM LTEAVQGGGS HIRDPVGGSL
     EYQFVPILKL IGTLLIMGVL TSDEVRLILL LIEPNVFGEA KEGEEGSEVV VAGEKEEVSK
     NEEKAVEAGE EETKESKPAA KGLLEKSLPE SVKHQMCELL HYFCDCELQH RIEAIVSFSD
     RFVSKLQYNQ KFRYNELMQA FNMSAAVTAK KTKEFRSPPH EQINILLNFS AGEDCPCPEE
     IQDELTSFHE ELRLHCGIPV EEQEEEQDTS IKGRLLALLY KIKGPPQKTE EQPAETEQAA
     PTNLKELISQ TITSWAQESH IQNPELVRVM FSLLRRQYDG IGELLRAMKK SYTISAASVQ
     DGINLLVSLG QIRSLLSVRM GKEEEKLMID GLGDIMNNKV FYQHPNLMRV LGMHETVMEV
     MVNVLGGDKS QEIAFPKMVA SCCRFLCYFC RISRQNQKAM FDHLSYLLEN SSVGLASEAM
     RGSTPLDVAA SSVMDNNGLA LALEEPDLEK VVMYLAGCGL QSCAILVAKG YPDLGWNPIE
     GERYLSFLRF VVFCNGESVE ENANVVVKLL IRRPECFGPA LRGEGGQGLL AAMKEAIKIS
     EDPALDLPKS PAGATAGSGE EEGEVIHMGN AIMSFYSALI DLLGRCAPEM HLINAGKGEA
     LRIRAILRSL VPTSDLVGII SIPLKMPVIN KDGSVTEPDM SACFCPDHKA PMVLFLDRVY
     GIEDQSFLLQ MLEVGFLPDL KASASLDTEV LSTTETALAM NRYIGSALLP LLTRCAALFG
     NTEHYAHLVD STLETIYRLS KGRSLTKAQR DAIEECLLAI CKHLRPSMMQ QLLRRLVFDV
     PLLTEYCKMP LRLLTNHYEQ NWKYYCLPSG MGGFGMASEE ELLLTKKLFW GIFDSLSQKK
     YDSELFKMAK SCLCAIAGAL PPDFVDTSLG ATVEKQESVD AQGNFEPKPI NTANISLPEK
     LDYIANKYAE HSHDKWASEK MSAGWKHGDS LDEQAKAHPL LKPYKSLSEK ERETYRWPVK
     ESLKSMLAMN WNIERTKEGE AMFQQRESEK QRKLSETQFV QSNGFSPAPM DLHNVTLSRE
     LQSMVEVVAE NYHNIWAKKK KSELLSKGGG LAHPLLVPYD TLTAKEKYRD KEKAQELFKF
     LQISGYAITS LRGLKDMEQD SSSMEKRFAY KFLKRLLKNI DSAQEFIAHL EAMATSGKTD
     KSPHDQEIKF FAKVLLPLID QTFKNHCLYF LSTPSKNLSS CGCASNKEKE MLTSLFCKMA
     ALVRHRISLF GSDSAIMVSC LHILSHSLDT RTVMKSGAEL VKVGFKAFFE NAAEDLEKLV
     EMLKLGKFMQ SRAQMKSVTQ SINYVTVALL PILTALFEHT RTHEFDVDLL VDDVQLSCYR
     ILMCFYSLGT GKNVFVERHL PAIGESLATL VGAMPVAFLE PHLNAHNPLS VFNTKTPRER
     AILSMPDTVE EMCPEMPRLD KLLKDVNDVS ECGARYSDMP QVIEVVLPML CNYLSYWWEK
     GPENSPPDTD CCTMVTSEHL SIILGNILKI LNNNLGIDDA PWMKRIAVYS QPIICKAGAD
     LLRTHFLPTM EKLKKKTVKV VSEEELLKAD GKGDNQEAEL LILDEFAVLC RDLYAFYPML
     IRYVDNNRSR WLKEPDADST ELFRMVAEIF ILWCKSNNFK REEQNFVIQN EINNLGFLTG
     EGKSKMSKQS GGDQERKHKR RRGEYYSIQT SLIVAALKKL LPIGLNMCTP GDQELISLAK
     IRYSLKDTDD EVKEHLRQNL HLQEKSDDPA VHWQLNLYKD VVVKSEEPSD SEHTVDRIQS
     ISAAVFNLEQ VKIISNTNED CCVEQPLRNK KCIVQKLLSK QRKRAVVACF RMAPLYNLPR
     HRAINFFIPA YERLWIAAEE YSFEEKLVQD LAKTPMKIVE EEEEEVAEIK PDPLHQLILH
     FSHNALTERS HLEVDPLYIA YADMMAKSCA EDEEEEEEEG REKTFEEKEM EKQKILYQQA
     RLHARGAAEM VLQMISASKG RLGPMVTCTL KLGISILNGG NVQVQQKMLG YLTDKRDAGF
     FKSLSGLMQS CSVLDLNAFE RQNKAEGLGM VTEEGSSSKV LQNDEFTKDL FRFLQLLCEG
     HNGDFQNFLR TQTGNTTTVN IIISTVDYLL RLQESISDFY WYYSGKDVID ETGKHNFSKA
     LSVAKQIFNS LTEYIQGPCI GNQQSLAHSR LWDAVVGFLH VFANMQMKLS QDASQIELLK
     ELMDLQKDMV VMLLSLLEGN VVNGTIGKQM VDTLVESSSN VEMILKFFDM FLKLKDLTTS
     DNFKEYDPEC KGIISKKEFQ KSMESQKQYN QSEIEFLLSC AEADENDMFN YKEFVERFHE
     PAKDIGFNVA VLLTNLSEHM PHDTRLATFL DLAESVLSYF EPYLGRIEIL GSAKRIERVY
     FEISESSREQ WEKPQVKESK RQFIFDVVNE GGESEKMEMF VNFCEDTIFE MQLASQISEP
     DAVEQPEEEE EEEVHNILEE LSGGDAAALE STSAFTTACR SVKKSLSEIR QIFTIKTARK
     QFKKIKKLSI KELITGFFSF FWMIFIGFFK GIISLVFGFF HVIWSSMFGG GLVEGAKNIK
     VTDILGNMPD PTQFGIHGDV GEGDKVEAME SSGSLDKAMA PAGDATENSD SEKEIEVVIL
     KKYRCFSQLP SCVLLSCSDS KFPSSNKTVL QKAAAKTAAP SESETEKADT ETREKEDKPK
     EEEAKEPAVE EKPKPRSSQP KEASPAFMST VFAILDVYLN KILNYLARNF YNLRFLALFV
     CFAINFILLF YKVTGEAEEE EEDEENHWGD DDDENTLFDM DEFVLQESTG YMLPTLRFLA
     IFHTVISLLC LVGYYCLKVP LVVFKREKEI ARKLEFDGLY ITEQPSDDDI KGQWDRLVIN
     TPSFPNNYWD KFIKRKVINK YGDMYGAERI AELLGLDKSA LDFDPTVETV EKEASLLSWL
     SSIDTKYHIW KLGVVLTDNY FLYLIWYTTM SIFGHFNNFF FAAHLLDIAM GFKTLRTILS
     SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED EDEPDMKCDD MMTCYLFHMY
     VGVRAGGGIG DELEDPAGDP YELYRILFDI TFFFFVIVIL LAIIQGLIID AFGELRDQQE
     QVKEDMETKC FICGIGNDYF DRTPHGFETH TLQEHNLANY LFFLMYLINK DETEHTGQES
     YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
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