ID A0A096M5Q0_POEFO Unreviewed; 1113 AA.
AC A0A096M5Q0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=SLIT-ROBO Rho GTPase-activating protein 1-like {ECO:0000313|Ensembl:ENSPFOP00000026741.1};
GN Name=SRGAP1 {ECO:0000313|Ensembl:ENSPFOP00000026741.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000026741.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000026741.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01008809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096M5Q0; -.
DR Ensembl; ENSPFOT00000023347.1; ENSPFOP00000026741.1; ENSPFOG00000002485.2.
DR GeneTree; ENSGT00950000182824; -.
DR OMA; LIVESCV; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF15; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 22..305
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 500..688
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 737..796
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 803..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..918
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 126854 MW; B0E414EA7332DFF4 CRC64;
FCFPESFLQS CSSCTSHLCM FSEIRTQLVE QQKCLDQQTE MRVQLLQDLQ DFFRKKAEIE
MEYSRNLEKL AERFMAKTRS TKDHQHFFRK DQNLLSPVNC WYLLLNQVRR ESKDHATLSD
IYLNNVIMRF MQISEDSTRL LKKSKEIAFQ LQEDLMKVLN ELYTVMKTYH MYHSESINAE
SKLKDAEKQE EKQIGRGDPV FSIRMEKKIE KIKEKRQAKY SENKLKSIKA RNEYLLTLEA
TNASVFKYYI HDLSDLIDCC DLGYHASLNR ALRTYLSAEY NLETSRHEGL DIIENAVDSL
DPRSDRQRFM EMYPTAFCPP TKFEFQSHMG DEVCHITAQP PVNGELILRF QQLQSRLATL
KIENEEVKKT SEATLTTIQD MVTIEDYDVS ECFHHSRSTE SVKSTVSETF LSKPSIAKRR
ANQQETEQFY FMKFREFLEG SNLISKLQAK HDLLKRTLGD GHRADYMTTR YRHPNGLYKT
LTGPRRPRPR SCFNVKLFNG NLESFIKDSG QAIPRVVESC IRYINLYGLQ HQGIFRVSGS
QLEVNDIKNS FERGNDPLTD DEDNHDINSV AGVLKLYFRG LENPLFPKER FNDLLSCIRI
DNLYERALYI RKILLTIPRL VLIVMRYLFA FLNHLSQYSD ENMMDPYNLA ICFGPTLMPT
PDTQDQVSCQ AHVNEIIKTI IIHHETIFPD AKELEGPIYE KCMAGGDYCE SPYSEHGALE
EVDNEGGTET HTSEDEGEPI EAIAKFDYVG RSSRELSFKK GASLLLYQRA SEDWWEGRHN
GIDGLVPHQY IVVQDIDDNF SDSLSQKADS EASSGHAGED KCSGKDISSP TDTRISEAYI
ARYAVGVDFK RLPQIKTTSV QIIAGVIANH FIHSPRGISP KIFLSLPPRL TACKISVHFV
PAKRGRTDSP ERRRRTGHGS LTNISRHESL KKMESPPIRR STSSGQYTGF TDSHHHHSGK
PLDPETIAQD IEETMNTALN ELRELERQSS AKHAPDVVLD TLEQRQTAGS GGGGPTMASS
NESLSPIHGV MLRSTANTEP PIRRSTSSSS EAMSTFKPMV APRMGVQLKP PALRPKPMVM
PKSNQAPQPP AGAAQDPLDK SCTITRDGKQ NSQ
//
