ID A0A096M7C6_POEFO Unreviewed; 1373 AA.
AC A0A096M7C6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Nuclear receptor coactivator 1 {ECO:0000313|Ensembl:ENSPFOP00000027317.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000027317.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000027317.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR EMBL; AYCK01015222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01015223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01015224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000025359.1; ENSPFOP00000027317.1; ENSPFOG00000004231.2.
DR GeneTree; ENSGT00950000183021; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18948; bHLH-PAS_NCoA1_SRC1; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR028819; NCOA1_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF1; NUCLEAR RECEPTOR COACTIVATOR 1; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 23..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 112..183
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1194..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1373 AA; 146098 MW; 7A061D95E03D74DC CRC64;
MSAVGESPLD PATPESRKRK GSPCDTSGQS VEKRRRELEC RYIEDLAELV SSNMGDIASL
SAKPDKCHIL RSTVDQIQQI KRREQEKAAL LSPDDDVQKS DVSSSSQGLV EKEALGPMLL
EALDGFFFVV NREGRIVFVS ENVIGYLGYT QEELINSSVY TILHVGDHNE FVRNLLPKSL
VNGAPWPQEA GRRNSHTFNC RMLKRPPDEA DAENLEARQQ YEIMQCFTVS QPRPVQEDGD
DLQSCLICIA CRIPRTESFI TKQDPTGKII SIETSALRAT GRPGWEDLVR KCIYAFFQSQ
GKEPSHAKKL LHEVMAHGTA VSPLYRFTLS DGTPLSAQTR CKFCCPPKPD VQPFIMGIHT
IDREHNTASS QENTNPSLPP TPSSIAHTPS RSPSLPPGSN SNQGSVLHAN NSGHNPSTPT
GYLTPNRTNC PQEVSSPSAL SSPHTATSTS FMSPRMPRAS PGLGGSPRVP GNPFSPSTPG
LQSPSGAPSS GGSAGSFPLS SPGLQRQASM PTGSSTRPLS AKPQTGAGDG GEDSNKAPLP
SASPLGNPRL NQLLDSSVTG AESNNNNSSP HPPQPSLGPQ CPASHSSLTE RHKILHRLLQ
DSSPNDAASA AEDGGNKNEV EIKKEPPVSP ALSTASHKSN SREPQDHQLL RFLLDTDEKD
LGDLPPPSAL SLQTVRVKVE KRASGDGLTC SEELVSTKSP SVTLTCKVSL KLALKLSVGP
ADPDALSQLL PGLRGPLGAK QVKLQSPTHL QPGEACTPRN VNVKREPPGT PNRGLVDGVP
TSGCSLQTQQ SFDFCNPATP SQQQGDLFQT PKDSSPFPET EVINPFAPST GLTKMDVGDS
QFQPLALTDT LSFDGHGTPL QPSLASPQDR QRVPGTLDEE LGPPTTPEAR NDEKALIEQL
VSFLSGTDES ELAELDKALG IDKLVQGACF DPFPQNLPPQ QPTATPVSME PKPPTYTSQF
PPASQAPFPP ELAAVGQQGV TFGAPRGAFP MGLRPGLTRP QGMGPQLRLP PNQLRLQLQQ
RLQGPQQLQN RLAAMNSFPG GPQQVNMGVR QAIQLPQMSS QQPPLNAQML AQRQRELYSI
HHRQQQQLLQ HKVRLMRQNM VAGAPAGGPG TPRAPKGPPT TSQQQFSFPP GFAPMAGSTP
TSPSHFSAAP GAPLDTKMSA RGPLSNQALL GGLQGQFDGA GNPTMQQGLF QQFGGSAAVQ
QDPPFPPEMS PTSPLLSPQN STSQSPLLQQ APTPGYQSPD MKSWQQTGLG GLFSQSGQSA
GQAFGQQGVY NNMSITVSMA GGTGGVSSLP PMGQAVGMSN SNLSNASSVC SEQQVQQVQV
FADVQCTVNL VSSDSYLNQG SMGAAAPQKG PVPQGSQTSQ AQQKSLLQQL LTE
//
