ID A0A096M983_POEFO Unreviewed; 387 AA.
AC A0A096M983;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=G protein subunit alpha 12 {ECO:0000313|Ensembl:ENSPFOP00000027974.1};
GN Name=GNA12 {ECO:0000313|Ensembl:ENSPFOP00000027974.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000027974.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000027974.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC {ECO:0000256|ARBA:ARBA00010405}.
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DR EMBL; AYCK01022516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01022525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096M983; -.
DR STRING; 48698.ENSPFOP00000027974; -.
DR Ensembl; ENSPFOT00000026435.1; ENSPFOP00000027974.1; ENSPFOG00000023931.1.
DR eggNOG; KOG0082; Eukaryota.
DR GeneTree; ENSGT00940000157636; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000469; Gprotein_alpha_12/13.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF130; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00440; GPROTEINA12.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 16..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 45170 MW; F24339F64FB1ABB9 CRC64;
MSGVVRTLSR CLLPAEATRE PGASKQGSRE RDAVQEREAR RRSREIDAML ARERRAVRRL
VKILLLGAGE SGKSTFLKQM RIINGQEFDK KALLDFRDTI YENILKGMRV LVDARDKLGI
TWQSCENEKQ GMLVMSWEGR VGTTRLEPSE FQLYVMALSA LWMDAGIQEA YTRRSEFQLL
KSTIKYFLNP LHEKGELIYI LFAQLVLFSR RSIDSEFLQK EIPGKPVYLN GKLSGRKGWF
QRFNKVTNVL RVRSTRPYPE CVCVQVLMED RRTNRLVESM NIFETIVNNK LFLNVSIILF
LNKTDLLVEK IRTVDIRKNF PEFRGDPRLL DNVQEFLVQS FSRKRRNRGK PLFHHFTTAV
DTENIRFVFH AVKDTILQEN LKDIMLQ
//
