ID   A0A096MCY6_POEFO        Unreviewed;       295 AA.
AC   A0A096MCY6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Ribonuclease H1 {ECO:0000256|PIRNR:PIRNR036852};
DE            Short=RNase H1 {ECO:0000256|PIRNR:PIRNR036852};
DE            EC=3.1.26.4 {ECO:0000256|PIRNR:PIRNR036852};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000029277.1, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000029277.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA
CC       hybrids. {ECO:0000256|PIRNR:PIRNR036852}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036852};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946,
CC         ECO:0000256|PIRNR:PIRNR036852};
CC   -!- SIMILARITY: Belongs to the RNase H family.
CC       {ECO:0000256|ARBA:ARBA00005300, ECO:0000256|PIRNR:PIRNR036852}.
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DR   EMBL; AYCK01019338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016519835.1; XM_016664349.1.
DR   AlphaFoldDB; A0A096MCY6; -.
DR   Ensembl; ENSPFOT00000022015.1; ENSPFOP00000029277.1; ENSPFOG00000002841.2.
DR   GeneID; 103156406; -.
DR   CTD; 246243; -.
DR   GeneTree; ENSGT00390000003466; -.
DR   OMA; ELWYGLY; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR   CDD; cd09280; RNase_HI_eukaryote_like; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR   InterPro; IPR009027; Ribosomal_bL9/RNase_H1_N.
DR   InterPro; IPR017067; RNase_H1_euk.
DR   InterPro; IPR011320; RNase_H1_N.
DR   InterPro; IPR037056; RNase_H1_N_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10642; RIBONUCLEASE H1; 1.
DR   PANTHER; PTHR10642:SF26; RIBONUCLEASE H1; 1.
DR   Pfam; PF01693; Cauli_VI; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   PIRSF; PIRSF036852; Ribonuclease_H1_euk; 1.
DR   SUPFAM; SSF55658; L9 N-domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|PIRNR:PIRNR036852};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR036852};
KW   Magnesium {ECO:0000256|PIRNR:PIRNR036852};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR036852};
KW   Nuclease {ECO:0000256|PIRNR:PIRNR036852};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT   DOMAIN          145..291
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
FT   REGION          107..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  33034 MW;  E3ACE51F857F9E7F CRC64;
     MFRIWTPVRT VLKRFCSSSD MPNPKGKFFY AVRKGIKPGV YKSWEECKIQ VDKFPAASFK
     KFGSERDAWA FFRGEDSSAV PDHSTGTRPG ETDVSLLPRR GPERVECIPL GKKRPHPEEG
     AELQPKRAKP SETSLAGSSD GFTYMGDAVV VYTDGCCSAN GRDRARAGIG VYWGRNHPLN
     VAERLQGRQT NQRAEIQAAC RALELARQNH IQKLVLYTDS KFTINGVTSW VKTWKVNGWR
     LKSGGPITNK EDFMTLDRLN SELDVVWMHI PGHAGFTGNE MADRLSREGA AKEPQ
//