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Database: UniProt
Entry: A0A096ME86_POEFO
LinkDB: A0A096ME86_POEFO
Original site: A0A096ME86_POEFO 
ID   A0A096ME86_POEFO        Unreviewed;      2290 AA.
AC   A0A096ME86;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   28-MAR-2018, entry version 21.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000029727, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000029727, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000029727};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000029727}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AYCK01017086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01017087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01017088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01017089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000022092; ENSPFOP00000029727; ENSPFOG00000017420.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; FREDNLI; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 3.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     67     84       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    105    126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    193    215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    271    292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    304    326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    459    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    484    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    584    606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    662    684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1086   1104       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1124   1144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1156   1175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1217   1239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1329   1354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1410   1428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1440   1458       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1531   1549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1619   1643       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1659   1694       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      680    707       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2290 AA;  258995 MW;  EEDFDF6BAF5F9B15 CRC64;
     AGFPPQPQCG QRMYKQSMAQ RARTMAIYNP NPVKQNCLTV NRSLFIFRED NLIRKYAKRI
     TEWPTPFEYM ILATIIANCI VLALEQHLPA SDKTPMSERL DDTEPYFIGI FCFEAAIKII
     ALGFAFHKGS YLRNGWNVMD FVVVLTGILA TVGSDFDLRT LRAVRVLRPL KLVSGIPSLQ
     VVLKSIMKAM VPLLQIGLLL FFAIVMFAII GVEFYMGKFH QSCFKGLTNT SERVVDWPCG
     SELPARTCPN GTVCQEYWTG PNFGITNFDN ILFAVLTVFQ CITMEGWVDI LYSTNDAVGN
     NWNWLYFIPL IIIGSFFMLN LVLGVLSGEF AKERERVEKR QEFLKLRRQQ QIERELTGYL
     EWICKAEEVL LEEEDEIAEE KAPMDVLKRG KIKKGKNDLI GAEEGDDPFA DMSSVVPPGS
     PFGRASVKSG GKMDSSSYFR RKEKRFRFFI RRMVKAQSFY WIVLCLVGLN TLCVAIVHYD
     QPDWLTRALY TAELVFLGLF LTEMTLKMYG LGARNYFHSS FNCFDFGVIV GSIFEVIWDM
     IKPGASFGIS VLRALRLLRI FKVTKYWNSL RNLVVSLLNS MKSIISLLFL LFLFIVVFAL
     LGMQLFGGQF NFEDETPTTN FDTFPAAILT VFQILTGEDW NAVMYHGIES HGGVHRGMFS
     SIYFIVLTLF GNYTLLNVFL AIAVDNLANA QELTKDEEEQ EEAANKKLAL QKALEVKEVS
     PMSAANISIA AFVKQNRDAL SRRSSVTSIQ SLKEQQRSAK SMSVWEQRTN QLRKHNMKTS
     TEALFNELDP DERLAASSAL HLHPDMKTHT DRPLVLEDKN GDQTRAGASE EATGPGVRDS
     FHSRRRHHHR DRNGDGGDGQ AVRRHSHHGR SREHNADAAQ DRERLRPQNG SPEEERGHRH
     HCSRRTPKEG NGPLTNGAQD DGKGRGDNGE KKLRSSRIQR RVQTIKSKRN QVRSFFSSFT
     FRDRQADTED DSLAGSPLQL KRSSLTPSEK QEDADNQKNS TRASQAALNS NAIHIPVTIT
     APPGETTIIP SEGTTSQKTK HIHEQHRLWE LPANGPRQIL PYSSMFVFGQ TNPVRRLCHY
     VVNLRYFEMC ILIVITMSSI TLAAEDPVEA NADRNIALKY LDYVFTGVFT FEMVIKMIDL
     GLLLHPGSYF RDLWNILDFI VVSGALVAFA CSGTKGKDIN TIKSLRVLRV LRPLKTIKRL
     PKLKAVFDCV VNSLKNVLNI LIVYILFMFI FAVIAVQLFK GKFFYCTDES KGLEKDCRGQ
     FLEYDPKEVT AQPREWKKYE FHYDNVLWAF LTLFTVSTGE GWPLVLKHSV DATYEDQGPS
     PGFRMETSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK AMSECSLEKN ERACIDFAIN
     ARPLTRYMPD NKQSFQYKMW KFVVSSPFEY AIMTLIALNT VVLMMKFYGA PMVYESMLKY
     LNIVFTGLFT LECILKIIAF NPLNYLKEPW NVFDFVTVIG SITDILFTEI NNKMINLSFL
     RLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIELN
     EETSINHHNN FQTFFQALTL LFRSATGEAW HEIMLACLSN RPCDKLSGNS GKECGSDFAY
     FYFVSFIFLC SFLMLNLFVA VIMDNFEYLT RDASILGPHH LDEFIRVWAE YDPAACGRIS
     YRDMYEMLRD MSPPLGLGKK CPPRVAYKRL VRMNMPIADD NTVHFTSTLM ALIRTALEIK
     LASEGVLAQR LCDADLKREI HRVWPNLQQK TVDLLVTPHK FSKFLLILCH FKCADNELTV
     GKVYAAHMIF DYYKQNRAKK LQQQNPSGIS QSKLGALFRP VLPFTHLHEP APPIKPAPPP
     EPKTQAPPTS TSSTATNMDA NMDAVLNQRT SIKHSQSGDF SPAAARLKPR RRLQRGQSED
     VHRCSRAQER QADPKPENMS DTEGRPGLEG HARAASLPRL NAEYHRSHPR HAPGTHLAPI
     VDLSPIKRSA SSLTPQQIGL RDYDLERVDQ SRFCAGPDPD RTHHHHHHHR CHRRRDKDKD
     RKQKSLDKTS SAPPSGAVGS FEDPSADGLS RERARERDRS RPHERRHHSS AGEKQRYYSC
     ERYGSREPGQ ARSAGPSRST SPGESQDSGL IKQVRHVSQG STVTKPPSGT SAQARGRRQL
     PQTPLTPRPA VAYKTPTSSA ATPSASTPGS RFVRAASEHD RLLAAQEEPK APVGPDSNAS
     RQQLDSSLLE EGEDFQDAVS SHGGGHSSRS AAAQGRAAGV PNGYHFTLGS APGSSRGVAG
     LREREEEDWC
//
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