ID A0A096MFE5_POEFO Unreviewed; 774 AA.
AC A0A096MFE5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=IkappaB kinase {ECO:0000256|ARBA:ARBA00012442};
DE EC=2.7.11.10 {ECO:0000256|ARBA:ARBA00012442};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000030136.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000030136.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-
CC seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA-
CC COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC ChEBI:CHEBI:456216; EC=2.7.11.10;
CC Evidence={ECO:0000256|ARBA:ARBA00023939};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AYCK01009758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096MFE5; -.
DR Ensembl; ENSPFOT00000024280.1; ENSPFOP00000030136.1; ENSPFOG00000012837.2.
DR GeneTree; ENSGT00950000182937; -.
DR OMA; SLMALDW; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008384; F:IkappaB kinase activity; IEA:UniProtKB-EC.
DR CDD; cd17046; Ubl_IKKA_like; 1.
DR Gene3D; 1.20.1270.250; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041185; IKBKB_SDD.
DR InterPro; IPR046375; IKBKB_SDD_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF7; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA; 1.
DR Pfam; PF18397; IKBKB_SDD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 32..322
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 325..391
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
SQ SEQUENCE 774 AA; 89215 MW; B8A9511F188E9521 CRC64;
LALNSENPPM PGLGGEAMNR VPLQQPQTCG PWELKERLGT GGFGNVTRWQ NKDTEEQIAL
KQCRQELSER NKERWCLEIQ IMRRLDHVNV VAAREVPQGM QKLVATNDLP LLAMEYCQGG
DLRKYLNVLE NCCGMREGSI LILLRDISSA LTYLHSKRII HRDLKPENIV LQQGEKRLIH
KIIDLGYAKE LDQSSLCTSF VGTLQYLAPE LIERQKYTVS VDYWSFGTLV FECITGFRPF
LPTWQPVPWH NKVRLKNDND IVVYESLSGD IRFSKNLPQP NNLNSLLSER LEKWLQLMLK
WSPKERGKDP NNTPSDCFHQ LESILQLKLV HVLNMMSAKI LIYAISDDET VANLQLRIEK
DTNIPAANQE LLLEAGLVLE PNALASQSAV DYMVDGRRTD YTLVFLFDCS SCTYEPQFSP
RILPENIRFI QKDPRHSLPY SQLRRTCGQV WHTIRSLKED WQRLQQGQKA AIMSLLRHNS
TLSKQKIEMV SMYQRLTAKL DFFNTSLHID MDKYNEQTAT GIASEKLLSV WREMEQTALS
CGQAQVTELE EEMMKLQPDI VDVQRQPWRS GETLDTLEGK AMELFRKLRE KPRDQRTPGD
GTETARLMVQ AVQFYEKKLR DFYTVLSKTA MCRHRVMELL PKVEEVVQKL AESEQVLMGL
QEKRQKELWD LLKIACVQSK VRSPVSGSPD GLRTPSSVPP LLTPRNSLQQ QLACSPVSWE
YSHRDESLVE ESRTFESRLQ SLLHETIQES ESSMEMLKEW TWLRGEQSFS SDLS
//