ID A0A096MGH8_POEFO Unreviewed; 2029 AA.
AC A0A096MGH8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Dedicator of cytokinesis 3 {ECO:0000313|Ensembl:ENSPFOP00000030519.1};
GN Name=DOCK3 {ECO:0000313|Ensembl:ENSPFOP00000030519.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000030519.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000030519.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; AYCK01006984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000030519; -.
DR Ensembl; ENSPFOT00000030150.1; ENSPFOP00000030519.1; ENSPFOG00000001524.2.
DR eggNOG; KOG1998; Eukaryota.
DR GeneTree; ENSGT00940000155514; -.
DR OMA; CADPHMN; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 381..559
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1184..1592
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1619..1639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1654..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1914..2029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1659..1692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1937..1951
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1979
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2003..2029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2029 AA; 233805 MW; EC12CED9BE696FFE CRC64;
GWYRGFSTKK PSIKGIFPVS YVHLKKSTVT NRGLCETVVP LEDPIITETT STLQEWGILW
KQLYVKHKVD LFHKLRHVMN ELIDLRRQLI QGHLAQDQTR EIKRHITVRL DWGNEHLGLD
LVPRKEFEMV DPDQISVSEL YKLHVSSRHC GQQSTNQGDS MRQRHGDGCR IPVSHHLFIN
LKSFTYNSIS EDADVFFSLY DSREAKQISE KFMVKLNKNG GPKNPEKVDR LCALFTDLSS
KDLKRDLYIV AHVIRTGRML LNDSKKGPPH VQYRRPYGCA VLAMSDVFHT ITDLKEEKDF
VLKVYTCNNE NEWYQVHENI IRKSNTKYSA PSTNYGLIIS LQLLRGELEQ IRRENQAVFN
RALALTRKLG FPDIILPGDT RNDLYLTLER GEFERGGKSV QKNIEVTLYV LYADGDTLKD
CISLGTGEPS TSEYRSFVLY HNNSPRWSEM VKLPIPIDRF RGSHLRFEFR HCSTKDKGEK
KLFGFAFTPL MREDGTTLSD EVHELYVYKC DENATFSNQG LYLSLPCCKE DFNSCPNLPA
NLPFQRSPKE TFWVSTILCS TKLTQNVDLL ALLNWKAHPD RVLDILGRLR QISGEEIVKF
LRDVLDTLFC LLDDNTDKYG PLVFQSLVFI INLLRDSRFY HFRPVIDSYI QNHFAGALAY
KELIRCLKWY MDRSAEVVRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG MEEEQFRASI
QELFQSIRFV LSLDSRSSEN LVFTQAALLN SFPDIFDELL QMFTVQEVAE YVRGTLGSMP
STVDIGQSMD VVKLQSIART VESRLFFFPE SRSILLPVVL HHIHLHLRQQ RELLICSGIL
SSIFSIIKTS SMESSVQEEV EMMVESLLDV LLQTLLSIMS KSHSVETSRG QRCPQCTAEI
TGEYVSCLLS LLRQMTEIHF HHLLNSFHSK EELKEFLLKI FCVFRNLMKL TIFPRDWSVM
RLLTSHVIVV TTQFLSPALH KNFSEGDFDF KVWNSFFSLT VLYINQPSLQ LEALPPAKRK
KTLDKHGDLR VIMAYELFSM WQKLGDNKPH FIPGMMGPFL GVTLVPQTEV RNIMIPIFHD
MMDWEQRKNG NFKQVEAELM DKLDSMVSDG KGDDNHRELF SLLTQLFGPY PSLLEKIEQE
TWRETGISFV TSVTRLVERI LDYRDCMKGD EMENKKIGGS VNLMSEVNKE DMYIRYIHKL
SDLHLQAEDF TEAAFTLLLY WELLQWEDRP LRDFLHYPCQ SEWQRKENLS RKILHYFNKG
KCWEYGISLC RELAFQYETL YDYQSLSWIR KMEAAYYDNI IEQQRIEPEF FKMGFYGRKF
PFFLRNKEFV CRGYDYERLE DFQQRMLGEF PQAIAMQHTN QPDDTILQSD AQYLQIYAVT
PVSDISDVPQ LERVPERIKS FYRINNVSRF HHDRPFHKGP KDRENEFRSL WIERTTLILA
RPLPGIARWA EVERRELVEV SPLENAIYVV ENKTQELRTL ISQYQHRQHH GNINPLSMCL
NGVIDAAVNG GIARYQEKAF FDKDYISSHP EDTERITHLK DLMQELVHIL GVGLAVHEKL
VHPEMRPLHK KLVDQFHMMR TGLHHCVPGM DRFGPAGCPG NHMSPESVRL MHRHSPLNLQ
GSIRHSSSSL SSHTSSEAGN LVIMTDGLMG EHPEEAMHMQ PSPSSSSLSS IRSNSSQIIN
SAPSSARGSP SLPDKSKHNR EVMMLLPSHR ERANNSMYYN VAENGQQQNN HMQRALLQQV
SPCKPCADPH MNLPEKVFSN ASSNWSLDGE NREQMNYVPA STGGVIMPPV PPRSFPSGHF
MMHCDAFHHQ STDPPPALPV RSLRKSPLHP IPGSPTSPQS ALGGSNSTLS GSASSGVSSL
SESNFGGQYP DPGPIRNDAL EPLPSHLWSP PDEYMPSPYL HIHYGGTEID SIDPVRPFHY
RNPASHPHGH PHPHSHPHSH PGLESHSHGP SQHHHVPPHV PHHIPYRRPQ PPAVPPKPYL
REGCIPEEEL TPQPIPLPRR IFHSPHGHRE DPGKHPWEQC ISEEHEENQ
//
