ID A0A096MK16_RAT Unreviewed; 1695 AA.
AC A0A096MK16;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 {ECO:0000313|Ensembl:ENSRNOP00000070433.2};
GN Name=Arap2 {ECO:0000313|Ensembl:ENSRNOP00000070433.2,
GN ECO:0000313|RGD:1306452};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000070433.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000070433.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070433.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000070433.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070433.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSRNOT00000082599.2; ENSRNOP00000070433.2; ENSRNOG00000056826.2.
DR AGR; RGD:1306452; -.
DR RGD; 1306452; Arap2.
DR VEuPathDB; HostDB:ENSRNOG00000056826; -.
DR GeneTree; ENSGT00940000160197; -.
DR OMA; FAHSCET; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000056826; Expressed in spleen and 19 other cell types or tissues.
DR ExpressionAtlas; A0A096MK16; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISO:RGD.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08856; ArfGap_ARAP2; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd17227; RA_ARAP2; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF1; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 4.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 1: Evidence at protein level;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A096MK16};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 10..70
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 478..570
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 583..675
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 672..807
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 888..999
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1112..1293
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1322..1416
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1426..1529
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1638..1667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1695 AA; 192612 MW; 0A8874F7A26432AD CRC64;
MSAVSEVNVD IQDFLMSINL EQYLLHFQEF GFYTVKDCTS INDNVLHQIG ISPTGHRRRI
LKQLQMIFSK MQDFPIYANV YKTKNGSTPK EQHSAPSSSS NTCIEFSDSV TVHRPGPAPS
EMVTTNVLSE GNCHSSTSHD KLSLSSSDLP CPEEEICQNV DSSQDYLFGR VNVKIDSLIT
QQAVEHTAGE EQTEKVNLVS EDSSKALNTN TECLPSVDHP ASETHCGNGT NGVLESFPPS
PFFQFQGEMV VNELYVPSSP IHSPMRSRSK LVSRPSRSFL LRHRPVPEIP GSTKSISGSY
FRDRKSITTS AGKSLTLKDA NEDNSTSIFP YGETFLFQRL ESSKKRSIKN EFWAHEDTVK
EEAATSRNSI LTKSSIYDSR KEKVSEDKVE DIWIPREDKN NLPQDSASES EYSTVEECFQ
SLRRKNSKAS KSRTQKAFYL DPFNRHSYPL SSTSENTDPS TIANAISPYA CFYGSSAAKV
KSGWLDKLSP QGKRMFQKRW VKFDGLSISY YNNDREMYSK GIIPLTAIST VRAQGDNKFE
IVTTQRTFVF RVEKEEERND WISVLLSALK SPSLTSQLQA AVAPEKCGYL ELRGYKAKIF
TVLRGNSVWL CKTEQDFKSG LGITIIPMNV ANVKQIDRAV KQSFEIITPY RSFSFTADSE
KEKQEWIEAV QQSIAETLSD YEVAEKIWFN ESNRSCADCK APDPDWASIN LCVVICKKCA
GQHRSLGPKD SKVRSLKMDA SIWSNELIEL FIVIGNKRAN DFWAGNLKKD EEIQMDSPVD
KRKIFITQKY KEGKFRKTFL ASLTKEELNK ALCAAVVKPD VLETMALLFS GADVMCATGD
PVHCTPYLLA KKAGQSLQME FLYHNKFSDF PQYDAHSEGG SSQEATQSTF LCDFLYQATA
SASRVSTEKK LLEETNKKWC VLEGGFLSYY ENDRCTTPNG TINISEVICL TVHKEDFYLN
TGPIFIFEIY LPSERVFLFG AKTSQIQRKW TETIAKRFVP FVAENLTEAD YDLIGQLFYK
DCHALDQWRK GWFAMDKSSL CFCLQTQEAQ EERMHLRRLQ ELTISTVVQN GEKVDVLLLV
EKGRTLYIHG YTKLDFTVWR NAIEKAAGTD GNTLQDQQLC KNDVPIIVNS CIAFVTQYGL
GCKYIYQKDG DPLSISELLE SFKKDARSVK LRVGKHQLED VTGVLKSFLS DIDDALLTKE
LYPYWVSALD AQDEKQRTDK YRAFICSLPG VNRATLAALI EHLYRVQKCS EINHMNAHNL
ALVFSSCLFQ TKGQTSEEVN VIEDLINNYV EIFEVKEDQV KQMDIENSFI TKWKNTQVSQ
AGDLLIEVFA ERKEPDCSII IRVSPVMEAE ELTNDILAIK NILPTKGDIW ATFEVIENEE
LERPLHYTEN VLEQVLQWSS LAEPGSAYLV VKRFLTIDTI KQCREKSIKE GILKLKEEPS
KILSGNKFQD RCVVLRDGHL FIYKDPKSTK HEKMFPLRLM KFYLGVKKKM KPPTSWGLTA
CSEKHHWHLC CDSLQAQMEW MASIFIAQHE NDIWPPAGKE RKRSITKNPK IGGLPLIPIQ
HEKNATQARK NIEMARAELE RLRLSERHDG DFTDSSLKDR ASIIGYCLEH KDEKLRNRAR
KHRSFNCLED TEAEVPPGLP KGYKGLKTVK KTEDRNSKAT LEPNNKLPSK VIEELSVVLQ
RSRSHPKELP DEQTL
//
