ID A0A096MMA6_PAPAN Unreviewed; 438 AA.
AC A0A096MMA6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Telomeric repeat-binding factor {ECO:0000256|PIRNR:PIRNR038016};
GN Name=TERF1 {ECO:0000313|Ensembl:ENSPANP00000000729.1};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000000729.1, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000000729.1, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000000729.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
CC {ECO:0000256|PIRNR:PIRNR038016}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR038016}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|PIRNR:PIRNR038016}.
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DR RefSeq; XP_003902908.1; XM_003902859.3.
DR AlphaFoldDB; A0A096MMA6; -.
DR STRING; 9555.ENSPANP00000000729; -.
DR Ensembl; ENSPANT00000020514.4; ENSPANP00000000729.1; ENSPANG00000025943.4.
DR GeneID; 101019317; -.
DR KEGG; panu:101019317; -.
DR CTD; 7013; -.
DR eggNOG; ENOG502RYK3; Eukaryota.
DR GeneTree; ENSGT00940000155268; -.
DR HOGENOM; CLU_034265_0_0_1; -.
DR OMA; HMENRYF; -.
DR OrthoDB; 207546at2759; -.
DR Proteomes; UP000028761; Chromosome 8.
DR Bgee; ENSPANG00000025943; Expressed in optic disc and 65 other cell types or tissues.
DR ExpressionAtlas; A0A096MMA6; baseline.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0070187; C:shelterin complex; IEA:Ensembl.
DR GO; GO:0071532; F:ankyrin repeat binding; IEA:Ensembl.
DR GO; GO:0008301; F:DNA binding, bending; IEA:Ensembl.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0098505; F:G-rich strand telomeric DNA binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003720; F:telomerase activity; IEA:Ensembl.
DR GO; GO:0045141; P:meiotic telomere clustering; IEA:Ensembl.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:Ensembl.
DR GO; GO:1904850; P:negative regulation of establishment of protein localization to telomere; IEA:Ensembl.
DR GO; GO:1904911; P:negative regulation of establishment of RNA localization to telomere; IEA:Ensembl.
DR GO; GO:0032211; P:negative regulation of telomere maintenance via telomerase; IEA:Ensembl.
DR GO; GO:1905839; P:negative regulation of telomeric D-loop disassembly; IEA:Ensembl.
DR GO; GO:1904792; P:positive regulation of shelterin complex assembly; IEA:Ensembl.
DR GO; GO:0016233; P:telomere capping; IEA:Ensembl.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IEA:Ensembl.
DR GO; GO:0061820; P:telomeric D-loop disassembly; IEA:Ensembl.
DR CDD; cd11660; SANT_TRF; 1.
DR CDD; cd00280; TRFH; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.25.40.210; Telomere repeat-binding factor, dimerisation domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR013867; Telomere_rpt-bd_fac_dimer_dom.
DR InterPro; IPR036507; Telomere_rpt-bd_fac_dimer_sf.
DR InterPro; IPR017357; TERF1/2.
DR PANTHER; PTHR46734:SF1; TELOMERIC REPEAT-BINDING FACTOR 1; 1.
DR PANTHER; PTHR46734; TELOMERIC REPEAT-BINDING FACTOR 1 TERF1; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF08558; TRF; 1.
DR PIRSF; PIRSF038016; Telomere_bd-1_Pin2; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF63600; Telomeric repeat binding factor (TRF) dimerisation domain; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR038016};
KW Chromosome {ECO:0000256|PIRNR:PIRNR038016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR038016};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038016};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Telomere {ECO:0000256|PIRNR:PIRNR038016}.
FT DOMAIN 374..431
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 374..427
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 50248 MW; C4157C4C36959AD2 CRC64;
MAEDASSAAP SPRGCADGRD ADTTEEQMAE TETNDEEQFD CQELLECQVQ VGAPEEEEEE
DEGLVTEAEA VAAGWMLDFL CLSLCRAFRD GRSEDFRRTR NSAEAIIHGL SSLTAYQLRT
IYICQFLTRI AAGKTLDAQF ENDERITPLE SALMIWGSIE KEHDKLHEEI QNLIKIQAIA
VCMENGNFKE AEEVFERIFG DPNSYMPFKS KLLMIISQKD TFHSFFQHFS YNHMMEKIKS
YVNYVLSEKS STFLMKAAAK VVESKRTRTI TSQDKPNGND VEMETEANLD TRKSVSDKQS
AVTESSEGTV SLLRSHKNLF VSKLQHGTQQ QDFNNKKERR IGTLQSTKKK KESRRATESR
IPVSKSQPVT PEKHRARKKQ AWLWEEDKNL RSGVRKYGEG NWSKILLHYK FNNRTSVMLK
DRWRTMKKLK LICSDSED
//
