GenomeNet

Database: UniProt
Entry: A0A096MUZ3_PAPAN
LinkDB: A0A096MUZ3_PAPAN
Original site: A0A096MUZ3_PAPAN 
ID   A0A096MUZ3_PAPAN        Unreviewed;      1023 AA.
AC   A0A096MUZ3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   24-JAN-2024, entry version 55.
DE   SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 5 {ECO:0000313|Ensembl:ENSPANP00000003662.3};
GN   Name=HERC5 {ECO:0000313|Ensembl:ENSPANP00000003662.3};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000003662.3, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000003662.3, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA   Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA   Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA   Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA   Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA   Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA   Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA   Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA   Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA   Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA   Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA   Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA   Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA   Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA   Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA   Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA   Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA   Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000003662.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A096MUZ3; -.
DR   Ensembl; ENSPANT00000007551.3; ENSPANP00000003662.3; ENSPANG00000014742.3.
DR   eggNOG; KOG0941; Eukaryota.
DR   GeneTree; ENSGT00940000162703; -.
DR   HOGENOM; CLU_002173_5_3_1; -.
DR   OMA; KHKAYLM; -.
DR   Proteomes; UP000028761; Chromosome 3.
DR   Bgee; ENSPANG00000014742; Expressed in testis and 63 other cell types or tissues.
DR   ExpressionAtlas; A0A096MUZ3; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0042296; F:ISG15 transferase activity; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR   GO; GO:0032020; P:ISG15-protein conjugation; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:Ensembl.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   PANTHER; PTHR45622:SF7; E3 ISG15--PROTEIN LIGASE HERC5; 1.
DR   PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00415; RCC1; 4.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS00626; RCC1_2; 2.
DR   PROSITE; PS50012; RCC1_3; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   REPEAT          156..208
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          209..260
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          261..312
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          314..376
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          701..1023
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        993
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1023 AA;  116765 MW;  88D2B7B714D66E1E CRC64;
     MERRSRRKSR RGGRSTAGQT AASQPAKSPD AQLWLFPSAA GFYRALLRRA EVTRQICCSP
     RRLAVLERGG AGVQVHQVLA GSGGARTPKC IKLGKNMKIH SVDQGADHML ILSSDGKPFE
     YDYSMKHLRS ESILQEKKII QITCGDYHSL ALSKGGELFA WGQNLHGQLG VGRKFPSTTT
     PQIVEHLAGV PLAQISAGEA HSMALSMSGN VYSWGKNEFG QLGLGHTESK DSPSLIEALD
     NQKVEFLACG GSHSALLTQD GLLFTFGAGK HGQLGHNSTQ NELRPCLVAE LVGNRVTQIA
     CGRWHTLAYV SDLGKVFSFG SGKDGQLGNG GTLDQLIPLP VKVSSSEELK LESHTSEKEL
     IMIAGGNQSI LLWIKKENSY VNLKRTIPTL NEGTVKRWIA DVETKRWHST KREIQEIFSS
     PACLTGSFLR KRRTAEMMPV YLDLNKARNI FKELTQKDWI TNMVTTCLKD NLLKRLPFHS
     PHQEALEVFF LLPECPVMHL SNNWESLVVP FAKVVCKMSD PSSLVLEEYW ATLQESTFSK
     LVQMFKTAVV CQLDYWDESA EENGNVQALL EMLKKLHRVN QMKCQLPESI FQVDELLYRL
     NFFVEVCRRC LWKMTVDTSE NAGCWVIFSH FPFIFNHLSK IKLLHTDTLL KIEGKKHKAY
     LMSAAIEEER ESEFALMPTF DLTVRRNHLI EDVLNQLSQF ENEDLRKELW VSFSGEIGYD
     LVGVKREFFY CLFEEMIQPE YGMFMYPEGA SCMWFPVRPK FEKKRYFFFG LLCGLSLFNC
     NVANLPFPLA LFKKLLDQMP SLEDLKELSP DLGKNLQTLL DDEGDNFEEV FYIHFNVHWD
     RNDTNLIPNG SSIIVNQTNK RDYVSKYIDY IFNDSVKAVY EEFRRGFYKM CDEDIIKLFH
     PEELKDVIVG HTDYDWKTFE KNARYEPGYN SSHPTIVMFW KAFHKLTLEE KKKFLVFLTG
     TDRLQTKDLK NMKITFCCPE SWNERDPMRA LTCFSVLFLP KYSTMETVEE ALQVAINNNR
     GFG
//
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