ID A0A096MUZ3_PAPAN Unreviewed; 1023 AA.
AC A0A096MUZ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 5 {ECO:0000313|Ensembl:ENSPANP00000003662.3};
GN Name=HERC5 {ECO:0000313|Ensembl:ENSPANP00000003662.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000003662.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000003662.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000003662.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A096MUZ3; -.
DR Ensembl; ENSPANT00000007551.3; ENSPANP00000003662.3; ENSPANG00000014742.3.
DR eggNOG; KOG0941; Eukaryota.
DR GeneTree; ENSGT00940000162703; -.
DR HOGENOM; CLU_002173_5_3_1; -.
DR OMA; KHKAYLM; -.
DR Proteomes; UP000028761; Chromosome 3.
DR Bgee; ENSPANG00000014742; Expressed in testis and 63 other cell types or tissues.
DR ExpressionAtlas; A0A096MUZ3; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0042296; F:ISG15 transferase activity; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0032020; P:ISG15-protein conjugation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:Ensembl.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF7; E3 ISG15--PROTEIN LIGASE HERC5; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 4.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 156..208
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 209..260
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 261..312
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 314..376
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 701..1023
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 993
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1023 AA; 116765 MW; 88D2B7B714D66E1E CRC64;
MERRSRRKSR RGGRSTAGQT AASQPAKSPD AQLWLFPSAA GFYRALLRRA EVTRQICCSP
RRLAVLERGG AGVQVHQVLA GSGGARTPKC IKLGKNMKIH SVDQGADHML ILSSDGKPFE
YDYSMKHLRS ESILQEKKII QITCGDYHSL ALSKGGELFA WGQNLHGQLG VGRKFPSTTT
PQIVEHLAGV PLAQISAGEA HSMALSMSGN VYSWGKNEFG QLGLGHTESK DSPSLIEALD
NQKVEFLACG GSHSALLTQD GLLFTFGAGK HGQLGHNSTQ NELRPCLVAE LVGNRVTQIA
CGRWHTLAYV SDLGKVFSFG SGKDGQLGNG GTLDQLIPLP VKVSSSEELK LESHTSEKEL
IMIAGGNQSI LLWIKKENSY VNLKRTIPTL NEGTVKRWIA DVETKRWHST KREIQEIFSS
PACLTGSFLR KRRTAEMMPV YLDLNKARNI FKELTQKDWI TNMVTTCLKD NLLKRLPFHS
PHQEALEVFF LLPECPVMHL SNNWESLVVP FAKVVCKMSD PSSLVLEEYW ATLQESTFSK
LVQMFKTAVV CQLDYWDESA EENGNVQALL EMLKKLHRVN QMKCQLPESI FQVDELLYRL
NFFVEVCRRC LWKMTVDTSE NAGCWVIFSH FPFIFNHLSK IKLLHTDTLL KIEGKKHKAY
LMSAAIEEER ESEFALMPTF DLTVRRNHLI EDVLNQLSQF ENEDLRKELW VSFSGEIGYD
LVGVKREFFY CLFEEMIQPE YGMFMYPEGA SCMWFPVRPK FEKKRYFFFG LLCGLSLFNC
NVANLPFPLA LFKKLLDQMP SLEDLKELSP DLGKNLQTLL DDEGDNFEEV FYIHFNVHWD
RNDTNLIPNG SSIIVNQTNK RDYVSKYIDY IFNDSVKAVY EEFRRGFYKM CDEDIIKLFH
PEELKDVIVG HTDYDWKTFE KNARYEPGYN SSHPTIVMFW KAFHKLTLEE KKKFLVFLTG
TDRLQTKDLK NMKITFCCPE SWNERDPMRA LTCFSVLFLP KYSTMETVEE ALQVAINNNR
GFG
//