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Database: UniProt
Entry: A0A096N5N9_PAPAN
LinkDB: A0A096N5N9_PAPAN
Original site: A0A096N5N9_PAPAN 
ID   A0A096N5N9_PAPAN        Unreviewed;      4899 AA.
AC   A0A096N5N9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   25-APR-2018, entry version 28.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPANP00000007752};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSPANP00000007752};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000007752, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000007752, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000007752}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AHZZ02017986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02017987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000016270; ENSPANP00000007752; ENSPANG00000024680.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; KRIRIHY; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000028761; Chromosome 1.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4220   4239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4440   4460       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4514   4533       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4700   4721       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4776   4799       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       82    137       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      144    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      197    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    315       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      323    380       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      571    781       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      997   1194       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1309   1534       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3963   3998       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      444    464       {ECO:0000256|SAM:Coils}.
FT   COILED     3028   3048       {ECO:0000256|SAM:Coils}.
FT   COILED     3293   3313       {ECO:0000256|SAM:Coils}.
FT   COILED     4352   4385       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4899 AA;  556522 MW;  A60E5DA917A8153C CRC64;
     DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT FVLEQSLSVR
     ALQEMLANTV EKSEGTAQGG GHRTLLYGHA ILLRHSYSGM YLCCLSTSRS STDKLAFDVG
     LQEDTTGEAC WWTIHPASKQ RSEGEKVRVG DDLILVSVSS ERYLHLSYGN GSLHVDAAFQ
     QTLWSVAPIS SGSEAAQGYL IGGDVLRLLH GHMDECLTVP SGEHGEEQRR TVHYEGGAVS
     VHARSLWRLE TLRVAWSGSH IRWGQPFRLR HVTTGKYLSL MEDKNLLLMD KEKADVKSTA
     FTFRSSKEKL DVGVRKEVDG MGTSEIKYGD SVCYIQHVDT GLWLTYQSVD VKSVRMGSIQ
     RKAIMHHEGH MDDGISLSRS QHEESRTARV IRSTVFLFNR FIRGLDALSK KAKASTVDLP
     IESVSLSLQD LIGYFHPPDE HLEHEDKQNR LRALKNRQNL FQEEGMINLV LECIDRLHVY
     SSAAHFADVA GREAGESWKS ILNSLYELLA ALIRGNRKNC AQFSGSLDWL ISRLERLEAS
     SGILEVLHCV LVESPEALNI IKEGHIKSII SLLDKHGRNH KVLDVLCSLC VCHGVAVRSN
     QHLICDNLLP GRDLLLQTRL VNHVSSMRPN IFLGVSEGSA QYKKWYYELM VDHTEPFVTA
     EATHLRVGWA STEGYSPYPG GGEEWGGNGV GDDLFSYGFD GLHLWSGCIA RTVSSPNQHL
     LRTDDVISCC LDLSAPSISF RINGQPVQGM FENFNIDGLF FPVVSFSAGI KVRFLLGGRH
     GEFKFLPPPG YAPCYEAVLP KEKLKVEHSR EYKQERTYTR DLLGPTVSLT QAAFTPIPVD
     TSQIVLPPHL ERIREKLAEN IHELWVMNKI ELGWQYGPVR DDNKRQHPCL VEFSKLPEQE
     RNYNLQMSLE TLKTLLALGC HVGISDEHAE DKVKKMKLPK NYQLTSGYKP APMDLSFIKL
     TPSQEAMVDK LAENAHNVWA RDRIRQGWTY GIQQDVKNRR NPRLVPYTLL DDRTKKSNKD
     SLREAVRTLL GYGYNLEAPD QDHAARAEVC SGTGERFRIF RAEKTYAVKA GRWYFEFETV
     TAGDMRVGWS RPGCQPDQEL GSDERAFAFD GFKAQRWHQG NEHYGRSWQA GDVVGCMVDM
     NEHTMMFTLN GEILLDDSGS ELAFKDFDVG DGFIPVCSLG VAQVGRMNFG KDVSTLKYFT
     ICGLQEGYEP FAVNTNRDIT MWLSKRLPQF LQVPSNHEHI EVTRIDGTID SSPCLKVTQK
     SFGSQNSHTD IMFYRLSMPI ECAEVFSKTV AGGLPGAGLF GPKNDLEDYD ADSDFEVLMK
     TAHGHLVPDR VDKDKEATKP EFNNHKDYAQ EKPSRLKQRF LLRRTKPDYS TSHSARLTED
     VLADDRDDYD FLMQTSTYYY SVRIFPGQEP ANVWVGWITS DFHQYDTGFD LDRVRTVTVT
     LGDEKGKVHE SIKRSNCYMV CAGESMSPGQ GRNNNGLEIG CVVDAASGLL TFIANGKELS
     TYYQVEPSTK LFPAVFAQAT SPNVFQFELG RIKNVMPLSA GLFKSEHKNP VPQCPPRLHV
     QFLSHVLWSR MPNQFLKVDV SRISERQGWL VQCLDPLQFM SLHIPEENRS VDILELTEQE
     ELLKFHYHTL RLYSAVCALG NHRVAHALCS HVDEPQLLYA IENKYMPGLL RAGYYDLLID
     IHLSSYATAR LMMNNEYIVP MTEETKSITL FPDENKKHGL PGIGLSTSLR PRMQFSSPSF
     VSVSNECYQY SPEFPLDILK AKTIQMLTEA VKEGSLHARD PVGGTTEFLF VPLIKLFYTL
     LIMGIFHNED LKHILQLIEP SVFKEAATPE EESDTLEKEL SVDDAKLQGA GEEEAKGGKR
     PKEGLLQMKL PEPVKLQMCL LLQYLCDCQV RHRIEAIVAF SDDFVAKLQD NQRFRYNEVM
     QALNMSAALT ARKTKEFRSP PQEQINMLLN FKDDKSECPC PEEIRDQLLD FHEDLMTHCG
     IELDEDGSLD GNSDLTIRGR LLSLVEKVTY LKKKQAEKPV ESDSKKSSTL QQLISETMVR
     WAQESVIEDP ELVRAMFVLL HRQYDGIGGL VRALPKTYTI NGVSVEDTIN LLASLGQIRS
     LLSVRMGKEE EKLMIRGLGD IMNNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGESKEIT
     FPKMVANCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG LASPAMRGST PLDVAAASVM
     DNNELALALR EPDLEKVVRY LAGCGLQSCQ LLVSKGYPDI GWNPVEGERY LDFLRFAVFC
     NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLAAME EAIKIAEDPS RDGPSPNSGS
     SKTLDTEEEE DDTIHMGNAI MTFYAALIDL LGRCAPEMHL IHAGKGEAIR IRSILRSLIP
     LGDLVGVISI AFQMPTIAKD GNVVEPDMSA GFCPDHKAAM VLFLDRVYGI EVQDFLLHLL
     EVGFLPDLRA AASLDTVALS ATDMALALNR YLCTAVLPLL TRCAPLFAGT EHHASLIDSL
     LHTVYRLSKG CSLTKAQRDS IEVCLLSICG QLRPSMMQHL LRRLVFDVPL LNEHAKMPLK
     LLTNHYERCW KYYCLPGGWG NFGAASEEEL HLSRKLFWGI FDALSQKKYE QELFKLALPC
     LSAVAGALPP DYMESNYVSM MEKQSSMDSE GNFNPQPVDT SNITIPEKLE YFINKYAEHS
     HDKWSMDKLA NGWIYGEIYS DSSKVQPLMK PYKLLSEKEK EIYRWPIKES LKTMLAWGWR
     IERTREGDSM ALYNRTRRIS QTSQVSVDAA HGYSPRAIDM SNVTLSRDLH AMAEMMAENY
     HNIWAKKKKM ELESKGGGNH PLLVPYDTLT AKEKAKDREK AQDILKFLQI NGYAVSRGFK
     DLELDTPSIE KRFAYSFLQQ LIRYVDEAHQ YILEFDGGSR GKGEHFPYEQ EIKFFAKVVL
     PLIDQYFKNH RLYFLSAASR PLCSGGHASN KEKEMNIEKF SGQFIRHFVS SSGNDATSIV
     NCLHILGQTL DARTVMKTGL ESVKSALRAF LDNAAEDLEK TMENLKQGQF THTRNQPKGV
     TQIINYTTVA LLPMLSSLFE HIGQHQFGED LILEDVQVSC YRILTSLYAL GTSKSIYVER
     QRSALGECLA AFAGAFPVAF LETHLDKHNI YSIYNTKSSR ERAALSLPTN VEDVCPNIPS
     LEKLMEEIVE LAESGIRYTQ MPHVMEVILP MLCSYMSRWW EHGPENNPER AEMCCTALNS
     EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIINKV KPQLLKTHFL PLMEKLKKKA
     AMVVSEEDHL KAEARGDMSE AELLILDEFT TLARDLYAFY PLLIRFVDYN RAKWLKEPNP
     EAEELFRMVA EVFIYWSKSH NFKREEQNFV VQNEINNMSF LITDTKSKMS KAAVSDQERK
     KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKNRFSLKD TEDEVRDIIR
     SNIHLQGKLE DPAIRWQMAL YKDLPNRTDD TSDPEKTVER VLDIANVLFH LEQVEHPQRS
     KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE
     DLAKPGADPP EEDEGTKRVD PLHQLILLFS RTALTEKCCH DEEDDDGEEE VKSFEEKEME
     KQKLLYQQAR LHDRGAAEMV LQTISASKGE TGPMVAATLK LGIAILNGGN STVQQKMLDY
     LKEKKDVGFF QSLAGLMQSC SVLDLNAFER QNKAEGLGMV TEEGSGEKVL QDDEFTCDLF
     RFLQLLCEGH NSDFQNYLRT QTGNNTTVNI IISTVDYLLR VQESISDFYW YYSGKDVIDE
     QGQRNFSKAI QVAKQVFNTL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMQMKLSQ
     DSSQIELLKE LMDLQKDMVV MLLSMLEGNV VNGTIGKQMV DMLVESSNNV EMILKFFDMF
     LKLKDLTSSD TFKEYDPDGK GVISKRDFHK AMESHKHYTQ SETEFLLSCA ETDENETLDY
     EEFVKRFHEP AKDIGFNVAV LLTNLSEHMP NDTRLQTFLE LAESVLNYFQ PFLGRIEIMG
     SAKRIERVYF EISESSRTQW EKPQVKESKR QFIFDVVNEG GEKEKMELFV NFCEDTIFEM
     QLAAQISESD LNERSANKED SEKERPEEQG PRMAFFSILT VKSALFALRY NILTLMRMLS
     LKSLKKQMKK VKKMTVKDMV TAFFSSYWSI FMTLLHFVAS VFRGFFRIIC SLLLGGSLVE
     GAKKIKVAEL LANMPDPTQD EVRGDGEEGE RKTLEAALPS EDLTDLKELT EESDLLSDIF
     GLDLKREGGQ YKLIPHNPNA GLSDLMSNPV PMPEVQEKFQ EQKAKEEEKE EKEETKSEPE
     KAEGEDGEKE EKAKEDKGKQ KLRQLHTHRY GEPEVPESAF WKKIIAYQQK LLNYFARNFY
     NMRMLALFVA FAINFILLFY KVSTSSVVEG KELPTRSSSE NAKVTSLDSG SHRIIAVHYV
     LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF KREKEVARKL EFDGLYITEQ
     PSEDDIKGQW DRLVINTQSF PNNYWDKFVK RKVMDKYGEF YGRDRISELL GMDKAALDFS
     DAREKKKPKK DSSLSAYQMW KLGVVFTDNS FLYLAWYMTM SVLGHYNNFF FAAHLLDIAM
     GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED GDTPDMKCDD
     MLTCYMFHMY VGVRAGGGIG DEIEDPAGDE YEIYRIIFDI TFFFFVIVIL LAIIQGLIID
     AFGELRDQQE QVKEDMETKC FICGIGNDYF DTVPHGFETH TLQEHNLANY LFFLMYLINK
     DETEHTGQES YVWKMYQERC WEFFPAGDCF RKQYEDQLN
//
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