ID A0A096N6F8_PAPAN Unreviewed; 1384 AA.
AC A0A096N6F8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Ubiquitin specific peptidase 19 {ECO:0000313|Ensembl:ENSPANP00000008058.3};
GN Name=USP19 {ECO:0000313|Ensembl:ENSPANP00000008058.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000008058.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000008058.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000008058.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSPANT00000020663.3; ENSPANP00000008058.3; ENSPANG00000008390.3.
DR eggNOG; KOG1870; Eukaryota.
DR GeneTree; ENSGT00940000159085; -.
DR HOGENOM; CLU_001060_8_1_1; -.
DR OrthoDB; 5474185at2759; -.
DR Proteomes; UP000028761; Chromosome 2.
DR Bgee; ENSPANG00000008390; Expressed in aorta and 65 other cell types or tissues.
DR ExpressionAtlas; A0A096N6F8; baseline.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06466; p23_CS_SGT1_like; 1.
DR CDD; cd06463; p23_like; 1.
DR CDD; cd02674; Peptidase_C19R; 1.
DR Gene3D; 2.60.40.790; -; 2.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF74; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19; 1.
DR Pfam; PF04969; CS; 2.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF16602; USP19_linker; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PRINTS; PR02045; F138DOMAIN.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 2.
DR PROSITE; PS51203; CS; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 113..202
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT DOMAIN 383..485
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT DOMAIN 600..1317
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT DOMAIN 894..936
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1384 AA; 152028 MW; 0F846A19C90BB89E CRC64;
MSGGASATGP RRGPPGLEDA TSKKQQKDRA NQESKDGDPR KETGSRYVAQ AGLELLASGD
PSASASCAAG ITGSRHHSRL FFPSLSGSAS TPREEQTKEG ACEDPHDLLA TPPPELLLDW
RQSAEEVIVK LHVGVGPLQL EDVDAAFTDT DCVVRFAGGQ QWGGVFYAEI KSSCAKVQTR
KGSLLHLTLP KKVPMLTWPS LLKKPLGTQE LVPGLQCQEN GQELSPTALE PGPEPHRAKQ
EARNQKRAQG RGEVGSGAGP GAQAGPSAKR AVHLCRGPEG EGSRDDPGPR GDAPPFVADP
ATQVEADEQL CIPPVNPQTC LLGSEENLAL LAGEKAVSPG NDPVSPAMVR SRNSGKDDRA
KEEMAVAADA ATLVDEPESM VNLAFVKNDS YEKGPDSVVV HVYVKEICRD TSRVLFREQD
FTLIFQTRDG NFLRLHPGCG PHTIFRWQVK LRNLIEPEQC TFCFTASRID ICLRKRQSQR
WGGLEAPATR GAVGGAKVAV PTGPTPLDST PPGGAPHPLT GQEEARAMEK DKSKARSEDT
GLESVATRTP MEHVTPKPET HLASPKPTCM VPPMPHSPVS GDSVEEEEEE EKKVCLPGFT
GLVNLGNTCF MNSVIQSLSN TRELRDFFHD RSFEAEINYN NPLGTGGRLA IGFAVLLRAL
WKGTHHAFQP SKLKAIVASK ASQFTGYAQH DAQEFMAFLL DGLHEDLNRI QNKPYTETVD
SDGRPDEVVA EEAWQRHKMR NDSFIVDLFQ GQYKSKLVCP VCAKVSITFD PFLYLPVPLP
QKQKVLPVFY FAREPHSKPI KFLVSVSKEN STASEVLDSL SQSVRVKPEN LRLAEVIKNR
FHRVFLPSHS LDTVSPSDML LCFELLSPEL AKERVVVLEV QQRPQVPSVP ISKCAACQRK
QQSEDEKLKR CTRCYRVGYC NQLCQKTHWP DHKGLCRPEN IGYPFLVSVP ASRLTYARLA
QLLEGYARYS VSVFQPPFQP GRMALESQSP GCTTLLSTGS LEAGDSERDP IQPPELQLVT
PMAEGDTGLP RVWAAPDRGP VPSTSGISSE ILASGPTEVG SLPAGERVSR PEAAVPGYQH
PSEAMNAHTP QFFIYKIDSS NREQRLEDKG DTPLELGDDC SLALVWRNNE RLQEFVLVAS
KELECAEDPG SAGEAARAGH FTLDQCLNLF TRPEVLAPEE AWYCPQCKQH REASKQLLLW
RLPNVLIVQL KRFSFRSFIW RDKINDLVEF PVRNLDLSKF CIGQKEEQLP SYDLYAVINH
YGGMIGGHYT ACARLPNDRS SQRSDVGWRL FDDSTVTTVD ESQVVTRYAY VLFYRRRNSP
VERPPRAGHS EHHPDLGPAA EAAASQGLGP GQAPEVAPTR TAPERFAPPV DRPAPTYSNM
EEVD
//
