ID A0A096NEN1_PAPAN Unreviewed; 1883 AA.
AC A0A096NEN1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Assembly factor for spindle microtubules {ECO:0000313|Ensembl:ENSPANP00000011358.3};
GN Name=ASPM {ECO:0000313|Ensembl:ENSPANP00000011358.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011358.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000011358.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000011358.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSPANT00000021137.3; ENSPANP00000011358.3; ENSPANG00000018539.3.
DR eggNOG; KOG0165; Eukaryota.
DR GeneTree; ENSGT00560000077332; -.
DR HOGENOM; CLU_260677_0_0_1; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000018539; Expressed in thymus and 29 other cell types or tissues.
DR ExpressionAtlas; A0A096NEN1; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 7.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 13.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 5.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 912..1048
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1102..1253
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1883 AA; 216709 MW; 06E5746FE67AF527 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPATK EEASSPPVLS LSHFCRSPFL CFGDVLLGDS
RTLPLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KEKIVISVNW TPFKEGRVRE
IMTFLVNDVL KHQAILLGNA EKQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLTLEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VDSVEKAVTE TSFNSINVND QSGENSKLIL TPNYSSTLNI
TQSQINFLSP DSFVNNSHGA NNELELVTCL SSDMFMTDNS KPVHLQSTTA HEIYQKILSP
DSFIKDNYGL NQDLESESVN PILSPNQFLK DNMAYMCTSQ QTCKVPLSNE NSQVPQSPQD
WSKSEVSPCI PECQGSKSPK GIFEELVEMK SNYYSFIKQN NPKFSAVQDI SSHSHDKQPK
RRPILSATVT KRKPTCTREN QTEINKPKAK RCLNSAVGEH EKVINNQKEK EDFHSYLPVI
DPVLSKSKSY KNQIMPSLTT ASVARKRKSD GSMEDANVRV AVTEHTEEQE IKRIHFSPSE
PKTSAVKKTK NVITPISKCI SNREKLNLKK KTDLLIFKTP ISKTSKRTKP IIAVAQSNLT
FIKPLKTDIP RHPMPFAAKN MFYDERWKEK QEQGFTWWLN FILTPDDFTV KTNISEVNAA
TLLLGVENQH KISVPRAPTK EEMSLRAYTA RCRLNRLRRA ACRLFTSEKM VKAIKKLEIE
IEARRLIVRK DRHLWKDVGE RQKVLNWLLS YNPLWLRIGL ETIYGELISL EDNSDVTGLA
MFILNRLLWN PDIAAEYRHP TVPHLYRDGH EGALSKFTLK KLLLLICFLD YAKISKLIDH
DPCLFCKDAE FKASKEILLA FSRDFLSGEG DLSRHLGLLG LPVNHVQTPF DEFDFAITNL
AVDLQCGVRL VRTMELLTQN WNLSKKLRIP AISRLQKMHN VDIVLQVLKS RGIELSDEHG
NTILSKDIVD RHREKTLRLL WKIAFAFQVD ISLNLDQLKE EIAFLKHTKS IKKTISLLSC
HSDALINKKK GKRDSGSFEQ YSENIKLLMD WVNAVCAFYN KKVENFTVSF SDGRVLCYLI
HHYHPCYVPF DAICQRTTQT VECTQTGSVV LNSSSESDDS SLDMSLKAFD HENTSELYKE
LLENEKKNFQ LIRSAVRDLG GIPAMINHSD MSNTIPDEKV VITYLSFLCA RLLDLRKEIR
AARLIQTTWR KYKLKTDLKR HQERDKAARM IQSAVINFLA KQRLRKRVNA ALIIQKYWRR
VLAQRKLLIL KKEKLEKVQN KAASLIQAMW RRYRAKKYLC KVKAACKIQA WYRCWRAHKE
YLAILKAVKI IQGCFYTKLE RTWFLNVRAS AIIIQRKWRA ILSAKIAHEH FLMIKRHRAA
CLIQAHYRGY KERQVFLRQK SAALIIQKYI RAREAGKRER IKYIEFKKST VILQALMRGW
LVRKRILEQK TKIRLLHFTA AAYYHLNALR IQRAYKLYLA VKNANKQVNS VICIQRWFRA
RLQQKKFIQK YSIKKIEHEG QECLSQQNRA ASVIQKAVRH FVFRKKQEKF TSGIIKIQAL
WRGYSWRKKN DCTKIKAIRL SLQVVNREIR EENKLYKRTA LALHYLLTYK HLSAILEALK
HLEVVTRLSP LCCENMAQSG AISKIFVLIR SCNRSVPCME VIRYAVQVLL NVSKYEKTTS
AVYDVENCID TLLELLQIYR EKPGNKVADK GGSIFTKTCC LLAVLLKTTN RASDVRSRSK
VVDRIYSLYK LTAHKHKMNT ERIFHKQKKN SSISIPFIPE TPVRTRIVSR LKPDWVLRRD
NMEEITNPLQ AIQMVMDTLG IPY
//
