ID A0A096NFB3_PAPAN Unreviewed; 734 AA.
AC A0A096NFB3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB6 {ECO:0000313|Ensembl:ENSPANP00000011606.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011606.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000011606.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000011606.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; A0A096NFB3; -.
DR Ensembl; ENSPANT00000001623.4; ENSPANP00000011606.3; ENSPANG00000018923.4.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01100000263555; -.
DR Proteomes; UP000028761; Chromosome 10.
DR Bgee; ENSPANG00000018923; Expressed in skeletal muscle tissue and 31 other cell types or tissues.
DR ExpressionAtlas; A0A096NFB3; baseline.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0008305; C:integrin complex; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF11; INTEGRIN BETA-6; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 656..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..412
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 570..653
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 677..723
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 155..162
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 210..251
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 384..616
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 410..414
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 425..437
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 434..469
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 439..448
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 475..480
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 477..510
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 482..495
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 497..502
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 522..529
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 543..548
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 545..591
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 550..560
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 563..566
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 570..579
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 576..648
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 595..624
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 734 AA; 80314 MW; 7BC922FCD42D06B0 CRC64;
MITYKNFTRP SGVGERCDTP ANLLAKGCQL NFIENPVSQV EILKNKPLSV GRQKNSSDIV
QIAPQSLILK LRPGGAQTLQ VHVRQTEDYP VDLYYLMDLS ASMDDDLNTI KELGSRLSKE
MSKLTSNFRL GFGSFVEKPV SPFVKTTPEE IANPCSSIPY FCLPTFGFKH ILPLTNDAER
FNEIVKNQKI SANIDTPEGG FDAIMQAAVC KEKIGWRNDS LHLLVFVSDA DSHFGMDSKL
AGIVIPNDGL CHLDSKNEYS MSTVLEYPTI GQLIDKLVQN NVLLIFAVTQ EQVHLYENYA
KLIPGATVGL LQKDSGNILQ LIISAYEELR SEVELEVLGD TEGLNLSFTA ICNNGTFFQH
QKKCSHMKVG DTASFNVTVN IPNCERRSRH IIIKPVGLGD ALELLVSPEC NCDCQKEVEV
NSSKCHHGNG SFQCGVCACH PGHMGPRCEC GEDMLSTDSC KEAPDHPSCS GRGDCYCGQC
ICHLSPYGNI YGPYCQCDNF SCVRHKGLLC GDNGWTGEYC NCTTSTDSCV SEDGVLCSGR
GDCVCGKCVC ANPGASGPTC ERCPTCGDPC NSKRSCIECH LSAAGQAREE CVDKCKLAGA
TISEEEDFSK DGSVSCSLQG ENECLITFLI TTDNEGKSII HSISEKDCPK PPNIPMIMLG
VSLAILLIGV VLLCIWKLLV SFHDRKEVAK FEAERSKAKW QTGTNPLYRG STSTFKNVTY
KHREKQKVDL STDG
//
