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Database: UniProt
Entry: A0A096NHK1_PAPAN
LinkDB: A0A096NHK1_PAPAN
Original site: A0A096NHK1_PAPAN 
ID   A0A096NHK1_PAPAN        Unreviewed;      2680 AA.
AC   A0A096NHK1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   05-DEC-2018, entry version 26.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSPANP00000012449};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSPANP00000012449};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000012449, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000012449, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000012449}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AHZZ02024528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02024529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000023131; ENSPANP00000012449; ENSPANG00000017411.
DR   GeneTree; ENSGT00940000157078; -.
DR   Proteomes; UP000028761; Chromosome 4.
DR   ExpressionAtlas; A0A096NHK1; baseline.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2210   2235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2247   2265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2277   2297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2333   2358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2378   2400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2507   2530       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      178    228       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      236    292       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      304    381       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      387    443       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2638   2665       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2680 AA;  305179 MW;  A31C740D734601CA CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQSCPFL RRAWRCGDRR
     VVVGDKVILN PVNAGQPLHA SNYELSDNAG CKEVNSVNCN TSWKINLFMQ FRDHLEEVLK
     GGDVVRLFHA EQEKFLTCDE YKGKLQVFLR TTLRQSATSA TSSNALWEVE VRRALWSTTT
     PCRGGAGHWN GLYRFKHLAT GNYLAAEENP SYKGDALDPK ATGMGAQGRA GRRNAGEKIK
     YRLVAVPHGN DIASLFELDP TTLQKTDSFV PRNSYVRLRH LCTNTWIQST NVPIDIEEER
     PIRLMLGTCP TKEDKEAFAI VSVPVSEIRD LDFANDASSM LASAVEKLNE GFISQNDRRF
     VIQLLEDLVF FVSDVPNNGQ NVLDIMVTKP NRERQKLMRE QNILKQIFGI LKAPFREKGG
     EGPLVRLEEL SDQKNAPYQH MFRLCYRVLR HSQEDYRKNQ EHIAKQFGMM QSQIGYDILA
     EDTITALLHN NRKLLEKHIT KTEVETFVSL VRKNREPRFL DYLSDLCVSN HIAIPVTQEL
     ICKCVLDPKN SDILIQTELR PVKEMAQSHE YLSIEYSDEE VWLTWTDKNN EHHEKSVRQL
     AQEARAGNAH DENVLSYYRY QLKLFARMCL DRQYLAIDEI SQQLGVDLIF LCMADEMLPF
     DLRASFCHLM LHVHVDRDPQ ELVTPVKFAR LWTEIPTAIT IKDYDSNLNA SRDDKKNKFA
     NTMEFVEDYL NNVVSEAVPF ANEEKNKLTF EVVSLAHNLI YFGFYSFSEL LRLTRTLLGI
     IDCVQGPPAM LQAYEDPGGK NVRRSIQGVG HMMSTMVLSR KQSVFGAPSL PAGASAAEPL
     DRSKFEENED IVVMETKLKI LEILQFILNV RLDYRISYLL SVFKKEFVEV FPMQDSGADG
     TAPAFDSTTA NMNLDRIGEQ AEAMFGVGKT SSMLEVDDEG GRMFLRVLIH LTMHDYAPLV
     SGALQLLFKH FSQRQEAMHT FKQVQLLISA QDVENYKVIK SELDRLRTMV EKSELWVDKK
     GSGKGEEVEA GAAKDKKERP TDEEGFLHPP GEKSSENYQI VKGILERLNK MCGVGEQMRK
     KQQRLLKNMD AHKVMLDLLQ IPYDKGDAKM MEILRYTHQF LQKFCAGNPG NQALLHKHLH
     LFLTPGLLEA ETMQHIFLNN YQLCSEISEP VLQHFVHLLA THGRHVQYLD FLHTVIKAEG
     KYVKKCQDMI MTELTNAGDD VVVFYNDKAS LAHLLDMMKA ARDGVEDHSP LMYHISLVDL
     LAACAEGKNV YTEIKCTSLL PLEDVVSVVT HEDCITEVKM AYVNFVNHCY VDTEVEMKEI
     YTSNHIWTLF ENFTLDMARV CSKREKRVAD PALEKYVLSV VLDTINAFFS SPFSENSTSL
     QTHQTIVVQL LQSTTRLLEC PWLQQQHKGS VEACIRTLAM VAKGRAISLP MDLDAHISAM
     LSSGASCAAA AQRNASSYKA TTRAFPRVTP TANQWDYKNI IEKLQDIITA LEERLKPLVQ
     AELSVLVDVL HWPELLFLEG SEAYQRCESG GFLSKLIQHT KDLMESEEKL CIKVLRTLQQ
     MLLKKTKYGD RGNQLRKMLL QNYLQNRKST SRGDLPDPMG TGLDPDWSAI AATQCRLDKE
     GATKLVCDLI TSTKNEKIFQ ESIGLAIRLL DGGNTEIQKS FHNLMMSDKK SERFFKVLHD
     RMKRAQQETK STVAVNMNDL GSQPHEDREP VDPTTKGRVA SFSIPGSSSR YSLGPSLRRG
     HEVSERVQSN EMGTSVLIMQ PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL
     DIMCGSTTGG LGLLGLYINE DNVGLVIQTL ETLTEYCQGP CHENQTCIVT HESNGIDIIT
     ALILNDISPL CKYRMDLVLQ LKDNASKLLL ALMESRHDSE NAERILISLR PQELVDVIKK
     AYLQEEEREN SEVSPREVGH NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL
     NNKQLSQMLK SSVPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP GICQFLTEET
     KHRLFTTTEQ DEQGSKVSDF FDQSSFLHNE MEWQRKLRSM PLIYWFSRRM TLWGSISFNL
     AVFINIIIAF FYPYMEGAST GVLDSPLISL LFWILICFSI AALFTKRYSI RPLIVALILR
     SIYYLGIGPT LNILGALNLT NKIVFVVSFV GNRGTFIRGY KAMVMDMEFL YHVGYILTSV
     LGLFAHELFY SILLFDLIYR EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL
     KDDFILEVDR LPNNHSTASP LGMPHGAAAF VDTCSGDKMD CVSGVSVPEV LEEDGELDST
     ERACDTLLMC IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL
     IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVSFEEHIKL EHNMWNYLYF
     IVLVRVKNKT DYTGPESYVA QMIKNKNLDW FPRMRAMSLV SNEGEGEQNE IRILQDKLNS
     TMKLVSHLTG QLNELKEQMT EQRKRRQRLG FVDVQNCMSR
//
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