ID A0A096NT56_PAPAN Unreviewed; 1765 AA.
AC A0A096NT56;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Trinucleotide repeat containing adaptor 6C {ECO:0000313|Ensembl:ENSPANP00000016227.3};
GN Name=TNRC6C {ECO:0000313|Ensembl:ENSPANP00000016227.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000016227.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000016227.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000016227.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
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DR Ensembl; ENSPANT00000028887.3; ENSPANP00000016227.3; ENSPANG00000019994.3.
DR eggNOG; ENOG502QWFQ; Eukaryota.
DR GeneTree; ENSGT00940000157598; -.
DR HOGENOM; CLU_001298_3_0_1; -.
DR OMA; VSWPPEF; -.
DR Proteomes; UP000028761; Chromosome 17.
DR Bgee; ENSPANG00000019994; Expressed in postnatal subventricular zone and 67 other cell types or tissues.
DR ExpressionAtlas; A0A096NT56; baseline.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12713; RRM_TNRC6C; 1.
DR CDD; cd14283; UBA_TNR6C; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR041917; TNR6C_UBA.
DR InterPro; IPR032226; TNRC6_PABC-bd.
DR InterPro; IPR034927; TNRC6C_RRM.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR PANTHER; PTHR13020:SF9; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF16608; TNRC6-PABC_bdg; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 1106..1151
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1298..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1515..1561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1677..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1515..1540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1677..1694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1765 AA; 183020 MW; 440DE1865BD41A4C CRC64;
LTCSSQPQPA GTSTSTSTST ISSSNNGKRS CAGGQQPAAS RYLPREVPPR FRQQEQKQLL
KRGQPLPTGT LTSVSPTQGA GPAGVSPPPL PGAGIQHHPS KLQPDLSHSG LADHYENSHW
GQQPTYRSEA NCSWDKVIID RTDKEAWPSI TGTETESASE CTTDTDSASN CGSENSSMAT
GSAQGNFTGH TKKTNGNNGT NGALVQSPSN QSALGAGGAN SNGSATRVWG VATGSSSGLA
HCSISGGDGK MDTMIGDGRS QNCWGASNSN AGINLNLNPN ANPAAWPVLG HEGTVATGNP
SSICSPVSAI GQNMGNQNGN PTGTLGAWGN LLPQESTEPQ TSTSQNVSFS AQPQNLNTDG
PNNTNPMNSS PNPINAMQTN GLPNWGMAVG MGAIIPPHLQ SLPGANGSSV SQVSGGSAEG
ISNSVWGLSP GNPATGNSNS GFSQGNGDTV NSALSAKQNG SSSAVQKEGN GGNAWDSGPP
AGPGILAWGR GSGNNGVGNI HSGAWGHPSR STSNGVNGEW GKPPNQHSNS DINGKGSTGW
ESPSVTSQNP TVQPGGEHMN SWAKAASSGT TASEGSSDGS GNHNEGSTGR EGTGEGRRRD
KGIIDQGHIQ LPRNDLDPRV LSNTGWGQTP VKQNTAWEFE ESPRSERKND NGTEAWGCAA
TQPSNSGGKN DGSIMNSTNT SSVSGWVNAP PAAVPANTGW GDSNNKAPSG PGVWGDSISS
TAVSTAAAAK SGHAWSGAAN QEDKSPTWGE PPKPKSQHWG DGQRSNPAWS AGGGDWADSS
SVLGHLGDGK KNGSGWDADS NRSGSGWNDT TRSGSSGWGN STNTKANPGT NWGETLKPGP
QQNWASKPQD NNVSNWGGAA SVKQTGTGWI GGPVPVKQKD SSEATGWEEP SPPSIRRKME
IDDGTSAWGD PSNYNNKTVN MWDRNNPVIQ SSTTTNTTTT TTTTSNTTHR VETPPPHQAN
TQLNRSPLLG PVSSGWGEMP HVHSKTENSW GEPSSPSPLV DNGTAAWGKP PSSGSGWGDH
PAEPPVAFGR AGAPGAASAL CKPASKSMQE GWGSGGDEMN LSTSQWEDEE GDVWNNAASQ
ESTSSCSSWG NAPKKGLQKG MKTSGKQDEA WIMSRLIKQL TDMGFPREPA EEALKSNNMN
LDQAMSALLE KKVDVDKRGL GVTDHNGMAA KPLGCRPPIS KESSMDRRVA ISGMFGNSGP
LNSSQLISVA QGTQFLSPQV RPSQNRTKAT GCRCPVFSEG PVLAAKTITN LQQQIQQHQL
AGSRPLLGQL VPLTAISPRA KTCLCTLCRQ IAMTLPSHSK RLPPGLNPNM NVNSMDMTSG
LSVKDPSQSQ SRLPQWTHPN SMDNLPSAAS PLEQNPSKHG AIPGGLSIGP PGKSSIDDSY
GRYDLIQNSE SPASPPVAVP HSWSRAKSDS DKISNGSSIN WPPEFHPGVP WKGLQNIDPE
NDPDVTPGSV PTGPTINTTI QDVNRYLLKS GGSSPPSSQN ATLPSSSAWP LSASGYSSSF
SSIASAPSVA GKLSDIKSTW SSGPASHTQA SLSHELWKVP RNTTAPTRPP PGLTNPKPSS
TWGASPLGWT SSYSSGSAWS TDASGRTSSW LVLRNLTPQI DGSTLRTLCL QHGPLITFHL
NLTQGNAVVR YSSKEEAAKA QKSLHMCVLG NTTILAEFAG EEEVNRFLAQ GQALPPTSSW
QSSSASSQPR LSAAGSSHGL VRSDAGHWNA PCLGGKGSSE LLWGGVPQYS SSLWGPPSAD
DSRVIGSPTP LTTLLPGDLL SGESL
//
