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Database: UniProt
Entry: A0A096NT77_PAPAN
LinkDB: A0A096NT77_PAPAN
Original site: A0A096NT77_PAPAN 
ID   A0A096NT77_PAPAN        Unreviewed;      4859 AA.
AC   A0A096NT77;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   25-APR-2018, entry version 24.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPANP00000016248};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSPANP00000016248};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000016248, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000016248, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000016248}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AHZZ02030730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000017854; ENSPANP00000016248; ENSPANG00000019876.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; ENETHEE; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000028761; Chromosome 7.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4176   4200       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4400   4420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4468   4487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4599   4617       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4660   4681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4740   4763       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3908   3943       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     3218   3238       {ECO:0000256|SAM:Coils}.
FT   COILED     4322   4349       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4859 AA;  550985 MW;  C29138398613C8E6 CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSLSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLILQDRAK ADTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT
     TQFLSQASFI PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGSRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR
     MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID
     GTMDSPPCLK VTHKTFGTQH SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPVPQCPPRL DVQTIQPVLW
     SRMPNSFLKV ESERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH
     TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRAGFYDLL ISIHLANAKE
     RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVATGEEHQ
     KQSPEIPLES LRTKALSMLT EAVQWSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSA ETEEGTEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP
     ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED
     TSWTGKLRAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDAELVR
     MMFNLLRRQY DSIGELLQAL RKTYTISHAS VSDTINLLAA LGQIRSLLSV RMGKEEELLM
     INGLGEIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLSTE KSQIAFPKMV ASCCRFLCYF
     CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALGLEEPDLE
     KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL
     LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVTEA DEEEEEIVHM
     GNAIMSFYSA LIDLLGRCAP EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS
     LNKDGSVSEP DMAANFCPDH KAPMVLFLDR VYGIKDQTFL LHLLEVGFLP DLRASASLDT
     VSLSTTEAAL ALNRYICSAV LPLLTRCAPL FAGTDHCTSL IDSTLQTIYR LSKGRSLTKA
     QRDTIEECLL AICNHLRPSM LQQLLRRLVF DVPQLNEYCK MPLKLLTNHY EQCWKYYCLP
     SGWGSYGLAV EEELHLTEKL FWGIFDSLSH KKYDPDLFRM ALPCLSAIAG ALPPDYLDTR
     ITATLEKQIS VDADGNFDPK PINTVNFSLP EKLEYIVTKY AEHSHDKWAC DKSQSGWKYG
     ISLDENVKTH PLIRPFKTLT EKEKEIYRWP ARESLKTMLA VGWTVERTKE GEALVQQREN
     EKLRSVSQAN QGNSYSPAPL DLSNVVLSRE LQGMVEVVAE NYHNIWAKKK KLELESKGGG
     SHPLLVPYDT LTAKEKFKDR EKAQDLFKFL QVNGVIVSRG MKDMELDASS MEKRFAYKFL
     KKILKYVDSA QEFIAHLEAI VSSGKTEKSP HDQEIKFFAK VLLPLVDQYF TNHRLYFLSS
     PLKPLSSSGY ASHKEKEMVA SLFCKLAALV RHRISLFGSD STTMVSCLHI LAQTLDTRTV
     MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL
     TSIFEHVAQH QFGMDLLLGD VQISCYHILC SLYSLGTGKN IYVERQRPAL GECVASLAAA
     IPVAFLEPTL NRYNPLSVFN TKTPRERSIL GIPDTVEDMC PDIPQLEGLM KEINDLAESG
     ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSTGQCC TKVTSEHLSL ILGNILKIIN
     NNLGIDEASW MKRIAVYAQP IISKARPDLL RSHFIPTLEK LKKKAVKTVQ EEEQLRADGK
     GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL KSPDADSDQL FRMVAEVFIL
     WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKSGGQ DQERKKTKRR GDLYSIQTSL
     IVAALKKMLP IGLNMCTPGD QELISLAKSR YGHRDTDEEV REHLRNNLHL QEKSDDPAVK
     WQLNLYKDVL KSEEPFNPEK TVERVQRISA AVFHLEQVEQ PLRSKKAVWH KLLSKQRKRA
     VVACFRMAPL YNLPRHKINN FFLSTFQQVW LEKVNEKTQY DRLIPILMKS PKVEEEEEEE
     TKKQPDPLHQ IILYFSRNAL TERSKLEDDP LYTSYSSMMA KSCQSGEDEE EDEDKEKTFE
     EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ
     KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT REKVLQNDEF
     TRDLFRFLQL LCEGHNSDFQ NFLRTQMGNT TTVNVIISTV DYLLRLQESI SDFYWYYSGK
     DIIDESGQHN FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ
     MKLSQDSSQI ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE SSTNVEMILK
     FFDMFLKLKD LTSSDTFKEY DPDGKGIISK REFQKAMEGQ KQYTQSEIDF LLSCAEADEN
     DMFNYIDFVD RFHEPAKDIG FNVAVLLTNL SEHMPNDSRL KCLLDPAESV LNYFEPYLGR
     IEIMGGAKKI ERVYFEISES SRTQWEKPQV KESKRQFIFD VVNEGGEQEK MELFVNFCED
     TIFEMQLASQ ISESDSADRP EEEEEDEDSS YVLEIAGEEE EDGSFEPASA FAMACASVKR
     NVADFLKRAT LKNLRKQYRN VKKMTAKELV KVLCSFFWML FLGLFQMLFT ILGGIFQILW
     STVFGGGLVE GAKNIRVTKI LGDMPDPTQF GIHDDTMEAE RAEVMEPGIT TELVHFIKGE
     KGDTDIMSDL FGLHPKKEGS LKHGPEVGLG DLSEIIGKDE PPTLESTVQK KRKAQAAEMK
     AANEAEGKVE SEKADMEDGE KEDKDKEEEQ AEHLWTEVTK KKKRRCGQKA EKPEAFTANF
     FKGLDIYQTK LLHYLARNFY NLRFLALFVA FAINFILLFY KVTEEPLEEE TEDVANLWNS
     FNDEEEEEAM VFFVLQESTG YMAPTLRALA IIHTIISLVC VVGYYCLKVP LVVFKREKEI
     ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN TPSFPNNYWD KFVKRKVINK YGDLYGAERI
     AELLGLDKNA LDFSPVEETK AEAASLVSWL SSIDMKYHIW KLGVVFTDNS FLYLAWYTTM
     SVLGHYNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF
     FRKFYNKSED DDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDP YEMYRIVFDI
     TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVREDMETKC FICGIGNDYF DTTPHGFETH
     TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
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