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Database: UniProt
Entry: A0A096NZ92_PAPAN
LinkDB: A0A096NZ92_PAPAN
Original site: A0A096NZ92_PAPAN 
ID   A0A096NZ92_PAPAN        Unreviewed;      1647 AA.
AC   A0A096NZ92;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 30.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSPANP00000018413};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018413, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000018413, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000018413}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AHZZ02004056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000023923; ENSPANP00000018413; ENSPANG00000005059.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000028761; Chromosome 12.
DR   ExpressionAtlas; A0A096NZ92; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 3.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF221; PTHR10037:SF221; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM      9     28       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     48     75       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    396    422       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    434    452       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    472    493       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    514    542       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    604    627       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    852    870       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    891    907       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    983   1003       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1052   1073       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1093   1116       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1175   1193       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1205   1223       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1230   1255       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1292   1320       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1396   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        3     81       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      154    353       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      404    632       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      641    846       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      850   1125       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1174   1429       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       72    117       {ECO:0000256|SAM:Coils}.
FT   COILED      345    365       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1647 AA;  188088 MW;  DA6307318BBC08FE CRC64;
     MKIGRNPDYG YTSFDTFSWA FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS
     FYLINLILAV VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSI
     RRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKNQKKLSS GEEKGDAEKL SKSDSEENIR
     RKSFHLGVEG HRRAHEKRLS TPSQSPLSIR GSLFSARRSS RTSLFSFKGR GRDIGSETEF
     ADDEHSIFGD NESRRGSLFV PHRPQERRSS NISQASRSPP MLPVNGKMHS AVDCNGVVSL
     VDGRSALMLP NGQLLPEGTT NQIHKKRRCS SYLLSEDMLN DPNLRQRAMS RASILTNTVE
     ELEESRQKCP PWWYRFAHKF LIWNCSPYWI KFKKCIYFIV MDPFVDLAIT ICIVLNTLFM
     AMEHHPMTEE FKNVLAIGNL VFTGIFAAEM VLKLIAMDPY EYFQVGWNIF DSLIVTLSLV
     ELFLADVEGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA
     VVGMQLFGKS YKECVCKIND DCTLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ
     AMCLIVYMMV MVIGNLVVLN LFLALLLSSF SSDNLTAIEE DPDANNLQIA VTRIKMGINY
     VKQTLREFIL KTFSKKPKIS REIRQTEDLN TKKENYISNY TLAEMSKGHN FLKEKDKISG
     FGSCVDKYLM EDSDGQSFIH NPSLTVTVPI APGESDLENM NTEELSSDSD SEYSKVRLNQ
     SSSSECSTVD NPFPGEGEEA EAEPMNSDEP EACFTDGCVR RFSCCQVNIE SGKGKIWWNI
     RKTCYKIVEH SWFESFIVLM ILLSSGALAF EDIYIERKKT IKIILEYADK IFTYIFILEM
     LLKWIAYGYK TYFTNAWCWL DFLIVDVSLV TLVANTLGYS DLGPIKSLRT LRALRPLRAL
     SRFEGMRVVV NALIGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYECI NTTDGSRFPA
     SQVPNRSECF ALMNVSQNVR WKNLKVNFDN VGLGYLSLLQ VATFKGWTII MYAAVDSVNV
     DKQPRYEYSL YMYIYFVIFI IFGSFFTLNL FIGVIIDNFN QQKKKLGGQD IFMTEEQKKY
     YNAMKKLGSK KPQKPIPRPG NKIQGCIFDL VTNQAFDISI MVLICLNMVT MMVEKEGQSL
     YMTDVLYWIN VVFIILFTGE CVLKLISLRY YYFTIGWNIF DFVVVIISIV GMFLADLIET
     YFVSPTLFRV IRLARIGRIL RLVKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF
     GMSNFAYVKK EDGINDMFNF ETFGNSMICL FQITTSAGWD GLLAPILNSK PPDCDPKKVH
     PGSSVEGDCG NPSVGIFYFV SYIIISFLVV VNMYIAVILE NFSVATEEST EPLSEDDFEM
     FYEVWEKFDP DATQFIEYNK LSDFAAALDP PLLIAKPNKV QLIAMDLPMV SGDRIHCLDI
     LFAFTKRVLG ESGEMDSLRS QMEERFMSAN PSKVSYEPIT TTLKRKQEDV SATVIQRAYR
     RYRLRQNVKN ISSIYIKDGD RDDDLLNKKD MVFDNVNENS SPEKTDATSS TTSPPSYDSV
     TKPDKEKYEQ DRTEKEDKGK DSKESKK
//
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