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Database: UniProt
Entry: A0A096NZH5_PAPAN
LinkDB: A0A096NZH5_PAPAN
Original site: A0A096NZH5_PAPAN 
ID   A0A096NZH5_PAPAN        Unreviewed;       407 AA.
AC   A0A096NZH5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN   Name=METTL8 {ECO:0000313|Ensembl:ENSPANP00000018496.1};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018496.1, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000018496.1, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA   Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA   Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA   Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA   Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA   Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA   Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA   Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA   Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA   Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA   Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA   Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA   Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA   Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA   Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA   Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA   Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA   Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000018496.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC       {ECO:0000256|PIRNR:PIRNR037755}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC       {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
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DR   RefSeq; XP_003907644.1; XM_003907595.2.
DR   RefSeq; XP_009180693.1; XM_009182429.2.
DR   RefSeq; XP_017802139.1; XM_017946650.1.
DR   RefSeq; XP_017802140.1; XM_017946651.1.
DR   AlphaFoldDB; A0A096NZH5; -.
DR   STRING; 9555.ENSPANP00000018496; -.
DR   Ensembl; ENSPANT00000014494.3; ENSPANP00000018496.1; ENSPANG00000005672.3.
DR   GeneID; 101018972; -.
DR   KEGG; panu:101018972; -.
DR   CTD; 79828; -.
DR   eggNOG; KOG2361; Eukaryota.
DR   GeneTree; ENSGT00940000159683; -.
DR   HOGENOM; CLU_029724_0_2_1; -.
DR   OMA; MFLFRDY; -.
DR   OrthoDB; 5471626at2759; -.
DR   Proteomes; UP000028761; Chromosome 10.
DR   Bgee; ENSPANG00000005672; Expressed in metanephros cortex and 66 other cell types or tissues.
DR   ExpressionAtlas; A0A096NZH5; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:Ensembl.
DR   GO; GO:0008174; F:mRNA methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR026113; METTL2/6/8-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR22809:SF3; MRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL8; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   PIRSF; PIRSF037755; Mettl2_prd; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Transferase {ECO:0000256|PIRNR:PIRNR037755};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          201..305
FT                   /note="Methyltransferase type 12"
FT                   /evidence="ECO:0000259|Pfam:PF08242"
FT   REGION          151..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  46901 MW;  8941BDE4C973ABE8 CRC64;
     MNMIWRNSIS CLRLGKVPHR YQSGYHPVAP LGSRILTDPA KVFEHNMWDH MQWSKEEEAA
     ARKKVKDNSA VRVLLKEQVK YEREASKYWD TFYKIHKNKF FKDRNWLLRE FPEILPVDQK
     PEEKARESSW DLVNTSATNC FSRMHCPTMP EEKNHYEKSS GSSEGQSKTE SDFSNLDSEK
     HKKGPMKTGL FPGSNATFRI LEVGCGAGNS VFPILNTLQN SPESFLYCCD FASGAVELIK
     SHSSYRAAQC FAFVHDVCDD GLPYPFPDGI LDVILLVFVL SSIHPDRMQG VVNRLSKLLK
     PGGMLLFRDY GRYDKTQLRF KKGRCLSENF YVRGDGTRAY FFTKGEVHSM FCKASLDEKQ
     NLVDHRLQVN RKKQVKMHRV WVQGKFQKPL HQTQNSSNMV STLLSQD
//
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