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Database: UniProt
Entry: A0A096NZM3_PAPAN
LinkDB: A0A096NZM3_PAPAN
Original site: A0A096NZM3_PAPAN 
ID   A0A096NZM3_PAPAN        Unreviewed;      1707 AA.
AC   A0A096NZM3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   24-JAN-2024, entry version 56.
DE   SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 {ECO:0000313|Ensembl:ENSPANP00000018544.3};
GN   Name=ARAP2 {ECO:0000313|Ensembl:ENSPANP00000018544.3};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018544.3, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000018544.3, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA   Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA   Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA   Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA   Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA   Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA   Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA   Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA   Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA   Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA   Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA   Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA   Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA   Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA   Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA   Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA   Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA   Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000018544.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; A0A096NZM3; -.
DR   STRING; 9555.ENSPANP00000018544; -.
DR   Ensembl; ENSPANT00000008590.3; ENSPANP00000018544.3; ENSPANG00000021175.3.
DR   eggNOG; KOG1117; Eukaryota.
DR   GeneTree; ENSGT00940000160197; -.
DR   HOGENOM; CLU_002900_0_1_1; -.
DR   OMA; TVEECFH; -.
DR   Proteomes; UP000028761; Chromosome 3.
DR   Bgee; ENSPANG00000021175; Expressed in thymus and 65 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd08856; ArfGap_ARAP2; 1.
DR   CDD; cd13253; PH1_ARAP; 1.
DR   CDD; cd13254; PH2_ARAP; 1.
DR   CDD; cd13256; PH3_ARAP; 1.
DR   CDD; cd13257; PH4_ARAP; 1.
DR   CDD; cd13259; PH5_ARAP; 1.
DR   CDD; cd17227; RA_ARAP2; 1.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   CDD; cd09490; SAM_Arap1_2_3; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR45899:SF1; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 4.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 5.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 4.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          10..70
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          485..577
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          590..682
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          679..814
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          881..1006
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1119..1300
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          1329..1423
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          1437..1540
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          107..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1641..1677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1657..1677
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1707 AA;  193768 MW;  2FFE987D1B284AC6 CRC64;
     MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG ISPTGHRRRI
     LKQLQIILSK MQDFPIYANV HKTKKNDDPS KDHNVPSSDQ NICIELSSSS SVQTPSPPQL
     ETVTKKLEDD ASVERSQYPQ SDNKLSPPKR DFPTAEEPHL NLGSLNDSLF GSENIKIESL
     ITKKTMDHTI EEQQTEKVKL ISENLNKLPN ADSECLSSVG CSTSETNSGN GTNGLLDGSP
     LSPFFKFQGE MIVNDLYVPS SPILAPMRSR SKLVSRPSRS FLLRHRPVPE IPGSTKGISG
     RDGVSLCCPR SWFQTPELKK SAHLGLPKCC AIFVKEEMLL PQLKNLWHGK KRSIKNEFLT
     QEEALKGEAT TATNSFIIKS SIYDNRKEKI SEDKVEDIWI PREDKNNFLI DTASESEYST
     VEECFQSLRR KNSKASKSRT QKALTLDSVN RHSYPLSSTS GNADSSAVSS QAISPYACFY
     GASVKKVKSG WLDKLSPQGK RMFQKRWVKF DGLSISYYNN EKEMYSKGII PLSAISTVRV
     QGDNKFEVVT TQRTFVFRVE KEEERNDWIS ILLNALKSQS LTSQSQGVVT PEKCGYLELR
     GYKAKIFTVL SGNSVWLCKN EQDFKSGLGI TIIPMNVANV KQVDRTVKQS FEIITPYRSF
     SFTAETEKEK QDWIEAVQQS IAETLSDYEV AEKIWFNESN RSCADCKAPD PDWASINLCV
     VICKKCAGQH RSLGPKDSKV RSLKMDASIW SNELIELFIV IGNKRANDFW AGNLQKDEEL
     HMDSPVEKRK NFITQKYKEG KFRKTLLASL TKEELNKALC AAVVKPDVLE TMALLFSGAD
     VMCATGDPVH STPYLLAKKA GQSLQMEFLY HNKFSDFPQH DIHSEGVLSQ ESSQSTFLCD
     FLYQAPSAAS KLSSEKKLLE ETNKKWCVLE GGFLSYYESD KSTTPNGTIN INEVICLAIH
     KEDFYLNTGP IFIFEIYLPS ERVFLFGAET SQTQRKWTEA IAKHFVPLFA ENLTEADYDL
     IGQLFYKDCH ALDQWRKGWF AMDKSSLHFC LQMQEVQGDR MHLRRLQELT ISTMVQNGEK
     LDVLLLVEKG RTLYIHGHTK LDFTVWHTAI EKAAGTDGNA LQDQQLSKND VPIIVNSCIA
     FVTQYGLGCK YIYQKNGDPL HISELLESFK KDARSFKLRA GKHQLEDVTG VLKSFLSDID
     DALLTKELYP YWISALDAQD DKERIKKYGA FIRSLPGVNR ATLAAIIEHL YRVQKCSEIN
     HMNAHNLALV FSSCLFQTKG QTSEEVNVIE DLINNYVEIF EVKEDQVKQM DIENSFITKW
     KDTQVSQAGD LLIEVYVERK EPDCSIIIRI SPVMEAEELT NDILAIKNII PTKGDIWATF
     EVIENEELER PLHYKENVLE QVLRWSSLAE PGSAYLVVKK FLTADTIKHC SDRSTLGSIK
     EGILKIKEEP SKILSGNKFQ DRYFVLRDGF LFLYKDVKSS KHDKMFSLSS VKFYRGVKKK
     MKPPTSWGLT AYSEKHHWHL CCDSSRTQTE WMTSIFIAQH ENDIWPPAGK ERKRSITKNP
     KIGGLPLIPI QHEGNATLAR KNIESARAEL ERLRLIEKCD KESVDSSLKE RASMVAHCLE
     HKDDKLRNRT RKHRSFNCLE DTEPEAPLGQ PKGHKGLKTL RKTEDRNSKA TLDSDHKLPS
     RVIEELNVVL QRSRTLPREL QDEQILK
//
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