ID A0A096NZM3_PAPAN Unreviewed; 1707 AA.
AC A0A096NZM3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 {ECO:0000313|Ensembl:ENSPANP00000018544.3};
GN Name=ARAP2 {ECO:0000313|Ensembl:ENSPANP00000018544.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000018544.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000018544.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000018544.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A096NZM3; -.
DR STRING; 9555.ENSPANP00000018544; -.
DR Ensembl; ENSPANT00000008590.3; ENSPANP00000018544.3; ENSPANG00000021175.3.
DR eggNOG; KOG1117; Eukaryota.
DR GeneTree; ENSGT00940000160197; -.
DR HOGENOM; CLU_002900_0_1_1; -.
DR OMA; TVEECFH; -.
DR Proteomes; UP000028761; Chromosome 3.
DR Bgee; ENSPANG00000021175; Expressed in thymus and 65 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08856; ArfGap_ARAP2; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd13256; PH3_ARAP; 1.
DR CDD; cd13257; PH4_ARAP; 1.
DR CDD; cd13259; PH5_ARAP; 1.
DR CDD; cd17227; RA_ARAP2; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF1; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 4.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 10..70
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 485..577
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 590..682
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 679..814
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 881..1006
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1119..1300
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1329..1423
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1437..1540
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 107..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1641..1677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1707 AA; 193768 MW; 2FFE987D1B284AC6 CRC64;
MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG ISPTGHRRRI
LKQLQIILSK MQDFPIYANV HKTKKNDDPS KDHNVPSSDQ NICIELSSSS SVQTPSPPQL
ETVTKKLEDD ASVERSQYPQ SDNKLSPPKR DFPTAEEPHL NLGSLNDSLF GSENIKIESL
ITKKTMDHTI EEQQTEKVKL ISENLNKLPN ADSECLSSVG CSTSETNSGN GTNGLLDGSP
LSPFFKFQGE MIVNDLYVPS SPILAPMRSR SKLVSRPSRS FLLRHRPVPE IPGSTKGISG
RDGVSLCCPR SWFQTPELKK SAHLGLPKCC AIFVKEEMLL PQLKNLWHGK KRSIKNEFLT
QEEALKGEAT TATNSFIIKS SIYDNRKEKI SEDKVEDIWI PREDKNNFLI DTASESEYST
VEECFQSLRR KNSKASKSRT QKALTLDSVN RHSYPLSSTS GNADSSAVSS QAISPYACFY
GASVKKVKSG WLDKLSPQGK RMFQKRWVKF DGLSISYYNN EKEMYSKGII PLSAISTVRV
QGDNKFEVVT TQRTFVFRVE KEEERNDWIS ILLNALKSQS LTSQSQGVVT PEKCGYLELR
GYKAKIFTVL SGNSVWLCKN EQDFKSGLGI TIIPMNVANV KQVDRTVKQS FEIITPYRSF
SFTAETEKEK QDWIEAVQQS IAETLSDYEV AEKIWFNESN RSCADCKAPD PDWASINLCV
VICKKCAGQH RSLGPKDSKV RSLKMDASIW SNELIELFIV IGNKRANDFW AGNLQKDEEL
HMDSPVEKRK NFITQKYKEG KFRKTLLASL TKEELNKALC AAVVKPDVLE TMALLFSGAD
VMCATGDPVH STPYLLAKKA GQSLQMEFLY HNKFSDFPQH DIHSEGVLSQ ESSQSTFLCD
FLYQAPSAAS KLSSEKKLLE ETNKKWCVLE GGFLSYYESD KSTTPNGTIN INEVICLAIH
KEDFYLNTGP IFIFEIYLPS ERVFLFGAET SQTQRKWTEA IAKHFVPLFA ENLTEADYDL
IGQLFYKDCH ALDQWRKGWF AMDKSSLHFC LQMQEVQGDR MHLRRLQELT ISTMVQNGEK
LDVLLLVEKG RTLYIHGHTK LDFTVWHTAI EKAAGTDGNA LQDQQLSKND VPIIVNSCIA
FVTQYGLGCK YIYQKNGDPL HISELLESFK KDARSFKLRA GKHQLEDVTG VLKSFLSDID
DALLTKELYP YWISALDAQD DKERIKKYGA FIRSLPGVNR ATLAAIIEHL YRVQKCSEIN
HMNAHNLALV FSSCLFQTKG QTSEEVNVIE DLINNYVEIF EVKEDQVKQM DIENSFITKW
KDTQVSQAGD LLIEVYVERK EPDCSIIIRI SPVMEAEELT NDILAIKNII PTKGDIWATF
EVIENEELER PLHYKENVLE QVLRWSSLAE PGSAYLVVKK FLTADTIKHC SDRSTLGSIK
EGILKIKEEP SKILSGNKFQ DRYFVLRDGF LFLYKDVKSS KHDKMFSLSS VKFYRGVKKK
MKPPTSWGLT AYSEKHHWHL CCDSSRTQTE WMTSIFIAQH ENDIWPPAGK ERKRSITKNP
KIGGLPLIPI QHEGNATLAR KNIESARAEL ERLRLIEKCD KESVDSSLKE RASMVAHCLE
HKDDKLRNRT RKHRSFNCLE DTEPEAPLGQ PKGHKGLKTL RKTEDRNSKA TLDSDHKLPS
RVIEELNVVL QRSRTLPREL QDEQILK
//