GenomeNet

Database: UniProt
Entry: A0A096P4K8_PAPAN
LinkDB: A0A096P4K8_PAPAN
Original site: A0A096P4K8_PAPAN 
ID   A0A096P4K8_PAPAN        Unreviewed;      2372 AA.
AC   A0A096P4K8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 28.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSPANP00000020283};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000020283, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000020283, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000020283}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AHZZ02010128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000018551; ENSPANP00000020283; ENSPANG00000022468.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   Proteomes; UP000028761; Chromosome 16.
DR   ExpressionAtlas; A0A096P4K8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0010045; P:response to nickel cation; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    121    140       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    212    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    340    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    367    392       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    742    760       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    772    793       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    863    882       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    939    962       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1275   1293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1313   1334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1346   1365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1410   1432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1512   1535       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1610   1631       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1643   1666       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1744   1763       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1827   1849       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    403       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      741    967       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1273   1545       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1609   1859       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1544   1571       {ECO:0000256|SAM:Coils}.
FT   COILED     1848   1872       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2372 AA;  262066 MW;  DBABB5CD000ECFCE CRC64;
     MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV
     FFYLSQDSRP RSWCLRTVCN PYPSGMLVIL LNCVTLGMFR PCEDIACDSQ RCRILQAFDD
     FIFAFFAVEM VVKMVALGIF GKKCYLGDTW NRLDFFIVIA GMLEYSLDLQ NVSFSAVRTV
     RVLRPLRAIN RVPSMRILVT LLLDTLPMLG NVLLLCFFVF FIFGIVGVQL WAGLLRNRCF
     LPENFSLPLS VDLERYYQTE NEDESPFICS QPRENGMRSC RSVPTLRGEG GGGPPCGLDY
     EAYNSSSNTT CVNWNQYYTN CSAGEHNPFK GAINFDNIGY AWIAIFQVIT LEGWVDIMYF
     VMDAHSFYNF IYFILLIIVG SFFMINLCLV VIATQFSETK QRESQLMREQ RVRFLSNAST
     LASFSEPGSC YEELLKYLVY ILRKAARRLA QVSRAAGVRA GLLSSPAPLG GQETQPSSSC
     SRSHRRLSVH HLVHHHHHHH HHYHLGNGTL RVPRASPEIQ DRDANGSRRL MLPPPSTPAL
     SGGPPGGAES VHSFYHADCH LEPVRCQAPR PRSPSEASGR TVGSGKVYPT VHTSPPPETL
     KEKALVEVAA SSGPATLTSL NIPPGPYSSM HKLLETQSTG ACQSSCKISS PCLKADSGAS
     GPDSCPYCAR AGAGEVELAD REMPDSDSEA VYEFTQDAQH SDLRDPHSWR PRSLGPDAEP
     SSVLAFWRLI CDTFRKIVDS KYFGRGIMIA ILVNTLSMGI EYHEQPEELT NALEISNIVF
     TSLFALEMLL KLLVYGPFGY IKNPYNIFDG VIVVISVWEI VGQQGGGLSV LRTFRLMRVL
     KLVRFLPALQ RQLVVLMKTM DNVATFCMLL MLFIFIFSIL GMHLFGCKFA SERDGDTLPD
     RKNFDSLLWA IVTVFQILTQ EDWNKVLYNG MASTSSWAAL YFIALMTFGN YVLFNLLVAI
     LVEGFQAEEI SKREDASGQL SCIQLPVDSQ GGDANKSESE PDFFSPSLDG DGDRKKCLAL
     VSLGEHPELR KSLLPPLIIH TAATPMSLPK STSTGLGEAL GPTSRRTSSS GSAEPGAAHE
     MKSPPSARSS PHSPWSAASS WTSRRSSRNS LGRAPSLKRR SPSGERRSLL SGEGQESQDE
     EESSEEERAS PAGSDRRHRE SLEREAKSSF DLPDTLQVPG LHRTASGRGS ASEHQDCNGK
     SASGRLARAL RPDDPPLDGD DADDEGNLSK GERVRAWIRA RLPACCLERD SWSAYIFPPQ
     SRFRLLCHRI ITHKMFDHVV LVIIFLNCIT IAMERPKIDP HSAERIFLTL SNYIFTAVFL
     AEMTVKVVAL GWCFGEQAYL RSSWNVLDGL LVLISVIDIL VSMVSDSGTK ILGMLRVLRL
     LRTLRPLRVI SRAQGLKLVV ETLMSSLKPI GNIVVICCAF FIIFGILGVQ LFKGKFFVCQ
     GEDTRNITNK SDCAEASYRW VRHKYNFDNL GQALMSLFVL ASKDGWVDIM YDGLDAVGVD
     QQPIMNHNPW MLLYFISFLL IVAFFVLNMF VGVVVENFHK CRQHQEEEEA RRREEKRLRR
     LEKKRRNLML DDVIASGSSA SAASEAQCKP YYSDYSRFRL LVHHLCTSHY LDLFITGVIG
     LNVVTMAMEH YQQPQILDEA LKICNYIFTV IFVLESVFKL VAFGFRRFFQ DRWNQLDLAI
     VLLSIMGITL EEIEVNASLP INPTIIRIMR VLRIARVLKL LKMAVGMRAL LDTVMQALPQ
     VGNLGLLFML LFFIFAALGV ELFGDLECDE THPCEGLGRH ATFRNFGMAF LTLFRVSTGD
     NWNGIMKDTL RDCDQESTCY NTVISPIYFV SFVLTAQFVL VNVVIAVLMK HLEESNKEAK
     EEAELEAELE LEMKTLSPQP HSPLGSPFLW PGVEGPDSPD SPKPGALHPA AHARSASHFS
     LEHPSDRQLF DTISLLIQGS LEWELKLMDE LAGPGGQPSA FPSAPSLGGS DPQIPLAEME
     ALSLTSEIVS EPSCSLALTD DSLPDDMHTL LLSAPESNVQ PHPTELPGPD LLTVRKSGVS
     RTHSLPNDSY MCRHGSIAEG PLGHRGWGLP KAQSGSVLSV HSQPADTSYI LQLPKDAPHL
     LQPYSTPTWG TIPKLPPPGR SPLAQRPLRR QVTNKTDLDV IAWQPEPLAE VSGPSLPLAR
     AYSFWGQSST QAQQHSRSHS NISKHMPPRA PCPGPQPNWD KGPPETRSSL ELDTELSWIS
     GDLLPPGGQE EPPSPRDLKK CYSVEAQSCQ RRPTSWLDEQ RRHSIAVSCL DSGSQPHLGT
     DASNLGGQPL GGPGSRPKKK LSPPSISIDP PESQGPRPPP SPGVCLRRRA PSSDSKDPLA
     SGPPDSMAAS PSPKKDVLSL SGLSSDPADL DP
//
DBGET integrated database retrieval system