ID A0A096QI23_MAIZE Unreviewed; 672 AA.
AC A0A096QI23;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Trifunctional UDP-glucose 46-dehydratase/UDP-4-keto-6-deoxy-D-glucose 35-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2 {ECO:0000313|EMBL:ONL96646.1};
GN ORFNames=ZEAMMB73_Zm00001d028654 {ECO:0000313|EMBL:ONL96646.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ONL96646.1};
RN [1] {ECO:0000313|EMBL:ONL96646.1, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb012590_P001,
RC ECO:0000313|Proteomes:UP000007305};
RC TISSUE=Seedling {ECO:0000313|EMBL:ONL96646.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:Zm00001eb012590_P001}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb012590_P001};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; CM007647; ONL96644.1; -; Genomic_DNA.
DR EMBL; CM007647; ONL96645.1; -; Genomic_DNA.
DR EMBL; CM007647; ONL96646.1; -; Genomic_DNA.
DR RefSeq; XP_008654228.1; XM_008656006.1.
DR RefSeq; XP_008654237.1; XM_008656015.1.
DR RefSeq; XP_008654239.1; XM_008656017.1.
DR RefSeq; XP_008654245.1; XM_008656023.1.
DR AlphaFoldDB; A0A096QI23; -.
DR SMR; A0A096QI23; -.
DR IntAct; A0A096QI23; 67.
DR STRING; 4577.A0A096QI23; -.
DR PaxDb; 4577-GRMZM2G044281_P03; -.
DR EnsemblPlants; Zm00001eb012590_T001; Zm00001eb012590_P001; Zm00001eb012590.
DR EnsemblPlants; Zm00001eb012590_T002; Zm00001eb012590_P002; Zm00001eb012590.
DR EnsemblPlants; Zm00001eb012590_T003; Zm00001eb012590_P003; Zm00001eb012590.
DR Gramene; Zm00001eb012590_T001; Zm00001eb012590_P001; Zm00001eb012590.
DR Gramene; Zm00001eb012590_T002; Zm00001eb012590_P002; Zm00001eb012590.
DR Gramene; Zm00001eb012590_T003; Zm00001eb012590_P003; Zm00001eb012590.
DR eggNOG; KOG0747; Eukaryota.
DR HOGENOM; CLU_026813_1_0_1; -.
DR InParanoid; A0A096QI23; -.
DR OMA; TIAWEHS; -.
DR OrthoDB; 5486426at2759; -.
DR Proteomes; UP000007305; Chromosome 1.
DR ExpressionAtlas; A0A096QI23; baseline and differential.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR43000:SF51; OS05G0203400 PROTEIN; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 1: Evidence at protein level;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A096QI23};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305}.
FT DOMAIN 10..315
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
FT DOMAIN 386..558
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
FT REGION 356..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 75938 MW; 56E5A1BD12FB3630 CRC64;
MATYEPKNIL ITGAAGFIAS HVTNCLVRNY PHYKIVVLDK LDYCSSLKNL NPSRASPNLK
FVKGDIASAD LVNHLLVTES IDTIMHFAAQ THVDNSFGNS FEFTKNNIYG THVLLEACKV
TGQIRRFIHV STDEVYGETD EDAVVGNHEA SQLLPTNPYS ATKAGAEMLV MAYGRSYGLP
VITTRGNNVY GPNQFPEKLI PKFILLAMRG LPLPIHGDGS NVRSYLYCED VAEAFEVVLH
KGEVGHVYNI GTVKERRVID VAKDICRLFG LDTEKVIRFV ENRPFNDQRY FLDDQKLKRL
GWAERTPWEE GLKKTIEWYT TNPDYWGDVT GALLPHPRML MIPGVERHNW TEDIKSLTSS
PAEASTTAPA TSAKRTTAAP QKPLYKFLIY GRTGWIGGLL GKICDKQGIP YEYGKGRLEE
RSQLLEDIRN VKPTQVFNAA GVTGRPNVDW CETHKQDTIR TNVVGILNLA DVCREQGLLM
INYATGCIFE YDAKHPERSG IGFKEEDTPN FTGSFYSKTK AMVEELLKEY DNVCTLRVRM
PISSDLNNPR NFITKIARYD KVVNIPNSMT ILDELLPISI EMAKRDCRGI WNFTNPGVVS
HNEILEMYKK YINPDFKWTN FTLEEQSKVI VAPRSNNEMD ASKLKAEFSQ LMSIKDSLIK
YVFEPNRKVP AN
//
