ID A0A097AYK0_9VIBR Unreviewed; 126 AA.
AC A0A097AYK0;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Glycine cleavage system H protein {ECO:0000256|HAMAP-Rule:MF_00272};
GN Name=gcvH {ECO:0000256|HAMAP-Rule:MF_00272,
GN ECO:0000313|EMBL:NOH38872.1};
GN ORFNames=F0224_03000 {ECO:0000313|EMBL:NOI74631.1}, F0267_11545
GN {ECO:0000313|EMBL:NOH38872.1}, TW71_11450
GN {ECO:0000313|EMBL:KJY72780.1};
OS Vibrio coralliilyticus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=190893 {ECO:0000313|EMBL:NOH38872.1, ECO:0000313|Proteomes:UP000577246};
RN [1] {ECO:0000313|EMBL:KJY72780.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S2052 {ECO:0000313|EMBL:KJY72780.1};
RX PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT "Genome mining reveals unlocked bioactive potential of marine Gram-negative
RT bacteria.";
RL BMC Genomics 16:158-158(2015).
RN [2] {ECO:0000313|Proteomes:UP000528382, ECO:0000313|Proteomes:UP000577246}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AIC-5 {ECO:0000313|EMBL:NOI74631.1,
RC ECO:0000313|Proteomes:UP000528382}, and X00-12-4
RC {ECO:0000313|EMBL:NOH38872.1, ECO:0000313|Proteomes:UP000577246};
RA Kehlet-Delgado H., Mueller R.S.;
RT "Draft genome sequencing and comparative genomics of hatchery-associated
RT Vibrios.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC glycine. The H protein shuttles the methylamine group of glycine from
CC the P protein to the T protein. {ECO:0000256|HAMAP-Rule:MF_00272}.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00272};
CC Note=Binds 1 lipoyl cofactor covalently. {ECO:0000256|HAMAP-
CC Rule:MF_00272};
CC -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC T, L and H. {ECO:0000256|HAMAP-Rule:MF_00272}.
CC -!- SIMILARITY: Belongs to the GcvH family. {ECO:0000256|ARBA:ARBA00009249,
CC ECO:0000256|HAMAP-Rule:MF_00272}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NOH38872.1}.
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DR EMBL; JXXR01000012; KJY72780.1; -; Genomic_DNA.
DR EMBL; VTYS01000009; NOH38872.1; -; Genomic_DNA.
DR EMBL; VTXB01000001; NOI74631.1; -; Genomic_DNA.
DR RefSeq; WP_006961445.1; NZ_VTYS01000009.1.
DR STRING; 190893.BA953_22910; -.
DR GeneID; 66921581; -.
DR KEGG; vct:JV59_21140; -.
DR KEGG; vcy:IX92_17975; -.
DR eggNOG; COG0509; Bacteria.
DR OrthoDB; 9796712at2; -.
DR Proteomes; UP000528382; Unassembled WGS sequence.
DR Proteomes; UP000577246; Unassembled WGS sequence.
DR GO; GO:0005960; C:glycine cleavage complex; IEA:InterPro.
DR GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR CDD; cd06848; GCS_H; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR HAMAP; MF_00272; GcvH; 1.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR002930; GCV_H.
DR InterPro; IPR033753; GCV_H/Fam206.
DR InterPro; IPR017453; GCV_H_sub.
DR InterPro; IPR011053; Single_hybrid_motif.
DR NCBIfam; TIGR00527; gcvH; 1.
DR PANTHER; PTHR11715; GLYCINE CLEAVAGE SYSTEM H PROTEIN; 1.
DR PANTHER; PTHR11715:SF41; GLYCINE CLEAVAGE SYSTEM H PROTEIN; 1.
DR Pfam; PF01597; GCV_H; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE 3: Inferred from homology;
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|HAMAP-Rule:MF_00272}.
FT DOMAIN 21..103
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT MOD_RES 62
FT /note="N6-lipoyllysine"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00272,
FT ECO:0000256|PIRSR:PIRSR617453-50"
SQ SEQUENCE 126 AA; 13906 MW; 15ED1DD4AA6DF252 CRC64;
MDNTLKFADS HEWVRDNGDG TVTIGISEHA QEMLGDVVFV DLPEVEAEIE AGDSFSLVES
VKAASDIYAP ITGEILEINE ELEDSPELIN EEPFEGGWIV KVKMSDASEL DNLKSAEEYL
NSIEDE
//
